Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma
Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR − CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumor...
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| Veröffentlicht in: | Cancer letters 2005-07, Vol.225 (2), p.261-266 |
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| container_title | Cancer letters |
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| creator | Razmkhah, Mahboobeh Talei, Abdul-Rasoul Doroudchi, Mehrnoosh Khalili-Azad, Tahereh Ghaderi, Abbas |
| description | Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR
− CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumors such as breast, lung, prostate and pancreatic cancers. SDF-1 gene polymorphism, known as SDF1-3′A, has been investigated in HIV-1 infection and the incidence of breast cancer. This investigation was aimed to study the frequency of SDF1-3′A mutation in Iranian women with breast cancer. Results showed that the frequency of AA and AG genotypes was higher among patients, while the frequency of GG genotype was lower compared to the controls. Thus AA and AG genotypes of SDF-1 may be considered as factors increasing the susceptibility of Iranian women to breast cancer. |
| doi_str_mv | 10.1016/j.canlet.2004.10.039 |
| format | Article |
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− CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumors such as breast, lung, prostate and pancreatic cancers. SDF-1 gene polymorphism, known as SDF1-3′A, has been investigated in HIV-1 infection and the incidence of breast cancer. This investigation was aimed to study the frequency of SDF1-3′A mutation in Iranian women with breast cancer. Results showed that the frequency of AA and AG genotypes was higher among patients, while the frequency of GG genotype was lower compared to the controls. Thus AA and AG genotypes of SDF-1 may be considered as factors increasing the susceptibility of Iranian women to breast cancer.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2004.10.039</identifier><identifier>PMID: 15978329</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Age ; Alleles ; Angiogenesis ; Autoimmune diseases ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cell adhesion & migration ; Cell cycle ; Chemokine ; Chemokine CXCL12 ; Chemokines ; Chemokines, CXC - genetics ; CXCR4 ; Deoxyribonucleic acid ; DNA ; Enzymes ; Female ; Gene Frequency - genetics ; Genes ; Genetic Predisposition to Disease - genetics ; Genotype ; Human immunodeficiency virus 1 ; Humans ; Iran ; Metastasis ; Neoplasm Staging ; SDF-1 ; SDF1-3′A ; Studies</subject><ispartof>Cancer letters, 2005-07, Vol.225 (2), p.261-266</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Jul 28, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-a8ae7a4831215f6874950cab4f2d9f294ff228d32f32f6f1620dcebe8c76f25d3</citedby><cites>FETCH-LOGICAL-c419t-a8ae7a4831215f6874950cab4f2d9f294ff228d32f32f6f1620dcebe8c76f25d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2004.10.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15978329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Razmkhah, Mahboobeh</creatorcontrib><creatorcontrib>Talei, Abdul-Rasoul</creatorcontrib><creatorcontrib>Doroudchi, Mehrnoosh</creatorcontrib><creatorcontrib>Khalili-Azad, Tahereh</creatorcontrib><creatorcontrib>Ghaderi, Abbas</creatorcontrib><title>Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR
− CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumors such as breast, lung, prostate and pancreatic cancers. SDF-1 gene polymorphism, known as SDF1-3′A, has been investigated in HIV-1 infection and the incidence of breast cancer. This investigation was aimed to study the frequency of SDF1-3′A mutation in Iranian women with breast cancer. Results showed that the frequency of AA and AG genotypes was higher among patients, while the frequency of GG genotype was lower compared to the controls. Thus AA and AG genotypes of SDF-1 may be considered as factors increasing the susceptibility of Iranian women to breast cancer.</description><subject>Age</subject><subject>Alleles</subject><subject>Angiogenesis</subject><subject>Autoimmune diseases</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell adhesion & migration</subject><subject>Cell cycle</subject><subject>Chemokine</subject><subject>Chemokine CXCL12</subject><subject>Chemokines</subject><subject>Chemokines, CXC - genetics</subject><subject>CXCR4</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Iran</subject><subject>Metastasis</subject><subject>Neoplasm Staging</subject><subject>SDF-1</subject><subject>SDF1-3′A</subject><subject>Studies</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6D0QCguihx3x2ksuCrK4KCx52PYd0UoEMme4xSS_svzfDDAgeFAoCxVNvUXkQek3JlhI6ftxtvZsztC0jRPTWlnDzBG2oVmxQRpOnaEM4EQPXXF6gF7XuCCFSKPkcXVBplObMbND9XSvL3mXsIechQEkPEHB0vi1loPj93eebgX7ALmfIULGbA65r9XBoaUo5tUfcFjwVcLVh74pPc097iZ5Flyu8Or-X6OfNl_vrb8Ptj6_frz_dDl5Q0wanHSgnNKeMyjhqJYwk3k0ismAiMyJGxnTgLPYaIx0ZCR4m0F6NkcnAL9G7U-6hLL9WqM3uUz0e4mZY1mpHZRQnnP0XpIorKaTo4Nu_wN2ylrkfYakkkisqOO-UOFG-LLUWiPZQ0t6VR0uJPcqxO3uSY49yjt0up4-9OYev0x7Cn6GzjQ5cnQDon_aQoNjqE8weQirgmw1L-veG3xAFoFA</recordid><startdate>20050728</startdate><enddate>20050728</enddate><creator>Razmkhah, Mahboobeh</creator><creator>Talei, Abdul-Rasoul</creator><creator>Doroudchi, Mehrnoosh</creator><creator>Khalili-Azad, Tahereh</creator><creator>Ghaderi, Abbas</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050728</creationdate><title>Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma</title><author>Razmkhah, Mahboobeh ; Talei, Abdul-Rasoul ; Doroudchi, Mehrnoosh ; Khalili-Azad, Tahereh ; Ghaderi, Abbas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-a8ae7a4831215f6874950cab4f2d9f294ff228d32f32f6f1620dcebe8c76f25d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Age</topic><topic>Alleles</topic><topic>Angiogenesis</topic><topic>Autoimmune diseases</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell adhesion & migration</topic><topic>Cell cycle</topic><topic>Chemokine</topic><topic>Chemokine CXCL12</topic><topic>Chemokines</topic><topic>Chemokines, CXC - genetics</topic><topic>CXCR4</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Iran</topic><topic>Metastasis</topic><topic>Neoplasm Staging</topic><topic>SDF-1</topic><topic>SDF1-3′A</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Razmkhah, Mahboobeh</creatorcontrib><creatorcontrib>Talei, Abdul-Rasoul</creatorcontrib><creatorcontrib>Doroudchi, Mehrnoosh</creatorcontrib><creatorcontrib>Khalili-Azad, Tahereh</creatorcontrib><creatorcontrib>Ghaderi, Abbas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Razmkhah, Mahboobeh</au><au>Talei, Abdul-Rasoul</au><au>Doroudchi, Mehrnoosh</au><au>Khalili-Azad, Tahereh</au><au>Ghaderi, Abbas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2005-07-28</date><risdate>2005</risdate><volume>225</volume><issue>2</issue><spage>261</spage><epage>266</epage><pages>261-266</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR
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| subjects | Age Alleles Angiogenesis Autoimmune diseases Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cell adhesion & migration Cell cycle Chemokine Chemokine CXCL12 Chemokines Chemokines, CXC - genetics CXCR4 Deoxyribonucleic acid DNA Enzymes Female Gene Frequency - genetics Genes Genetic Predisposition to Disease - genetics Genotype Human immunodeficiency virus 1 Humans Iran Metastasis Neoplasm Staging SDF-1 SDF1-3′A Studies |
| title | Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma |
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