EFFECT OF THEOPHYLLINE AND AMINOPHYLLINE ON TRANSMITTER RELEASE AT THE MAMMALIAN NEUROMUSCULAR JUNCTION IS NOT MEDIATED BY cAMP

SUMMARY 1 Theophylline and aminophylline have been widely used as inhibitors of phosphodiesterase when examining the role of cAMP in regulating cell function. In reality, however, these phosphodiesterase inhibitors may have additional sites of action that could complicate the interpretation of the r...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2006-05, Vol.33 (5-6), p.465-470
Hauptverfasser:	Nickels, Travis J, Schwartz, Andrew D, Blevins, Dustin E, Drummond, Justin T, Reed, Grant W, Wilson, David F
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials adenosine Adenosine A1 Receptor Antagonists aminophylline Aminophylline - pharmacology Animals Calcium Channel Blockers - pharmacology cyclic AMP Cyclic AMP - metabolism Electric Stimulation end-plate potential Gallic Acid - analogs & derivatives Gallic Acid - pharmacology In Vitro Techniques Male methylxanthines neuromuscular junction Neuromuscular Junction - drug effects Neuromuscular Junction - metabolism Neurotransmitter Agents - metabolism phosphodiesterase inhibitors Phosphodiesterase Inhibitors - pharmacology quantal release Rats Rats, Sprague-Dawley Receptor, Adenosine A1 - metabolism Ryanodine Receptor Calcium Release Channel - drug effects Ryanodine Receptor Calcium Release Channel - metabolism ryanodine receptors theophylline Theophylline - pharmacology Xanthines - pharmacology
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