RNA-directed transcriptional gene silencing in mammals
RNA interference is a highly conserved pathway mediating sequence-specific RNA degradation. In plants, the short RNA intermediates of this pathway can also drive transcriptional silencing of target genes by DNA methylation. Until recently, there was no evidence that a similar pathway operated in mam...
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| Veröffentlicht in: | Trends in genetics 2005-07, Vol.21 (7), p.370-373 |
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| creator | Bayne, Elizabeth H. Allshire, Robin C. |
| description | RNA interference is a highly conserved pathway mediating sequence-specific RNA degradation. In plants, the short RNA intermediates of this pathway can also drive transcriptional silencing of target genes by DNA methylation. Until recently, there was no evidence that a similar pathway operated in mammals; two new studies suggest that small RNAs can direct DNA methylation and chromatin modification in human cells. Although further investigation is required to determine how widespread RNA-directed DNA methylation is in mammals, the findings raise the possibility that this pathway, far from being merely a curiosity of plant systems, is a conserved mechanism for control of gene expression. |
| doi_str_mv | 10.1016/j.tig.2005.05.007 |
| format | Article |
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| ispartof | Trends in genetics, 2005-07, Vol.21 (7), p.370-373 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Biological and medical sciences Chromatin - metabolism DNA Methylation Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Silencing Genetic Techniques Genetics of eukaryotes. Biological and molecular evolution Humans Mammalia Molecular and cellular biology RNA - genetics RNA Interference RNA, Small Interfering - metabolism Transcription, Genetic |
| title | RNA-directed transcriptional gene silencing in mammals |
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