Is Quantitative Real-Time RT-PCR an Adjunct to Immunohistochemistry for the Evaluation of ErbB2 Status in Transitional Carcinoma of the Bladder?

To test different approaches of evaluation of the ErbB2 status in a large series of human transitional cell carcinoma (TCC) of the bladder with the prospect of finding targeted therapies. ErbB2 status of 73 human TCC samples was analyzed by both immunohistochemistry (IHC) and by quantification of mR...

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Veröffentlicht in:	European urology 2006-06, Vol.49 (6), p.1035-1043
Hauptverfasser:	Amsellem-Ouazana, Delphine, Bièche, Ivan, Molinié, Vincent, Elie, Caroline, Vieillefond, Annick, Tozlu, Sengül, Botto, Henry, Debré, Bernard, Lidereau, Rosette
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Bladder cancer Carcinoma, Transitional Cell - diagnosis Carcinoma, Transitional Cell - genetics ERBB2 Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Male Middle Aged Quantitative real-time PCR Receptor, ErbB-2 - genetics Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - analysis RNA, Messenger - biosynthesis Tyrosine kinase receptors Urinary Bladder Neoplasms - genetics
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