Nicotine suppresses the P13 auditory evoked potential by acting on the pedunculopontine nucleus in the rat

We identified a potential novel site of action for nicotine (NIC) since (a) systemic injection of NIC led to a dose-dependent decrease in the amplitude of the sleep state-dependent, vertex-recorded, P13 midlatency auditory evoked potential (generated by the reticular activating system, RAS), (b) loc...

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Veröffentlicht in:	Experimental brain research 2005-07, Vol.164 (1), p.109-119
Hauptverfasser:	MAMIYA, N, BUCHANAN, R, WALLACE, T, SKINNER, R. D, GARCIA-RILL, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Anti-Anxiety Agents - pharmacology Arousal - drug effects Arousal - physiology Biological and medical sciences Cholinergic Fibers - drug effects Cholinergic Fibers - physiology Dose-Response Relationship, Drug Down-Regulation - drug effects Down-Regulation - physiology Electrodes Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Fundamental and applied biological sciences. Psychology Male Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Neural Inhibition - drug effects Neural Inhibition - physiology Neural Pathways - drug effects Neural Pathways - physiology Neurosciences Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Pedunculopontine Tegmental Nucleus - drug effects Pedunculopontine Tegmental Nucleus - physiology Rats Rats, Sprague-Dawley Reflex, Startle - drug effects Reflex, Startle - physiology Reticular Formation - drug effects Reticular Formation - physiology Schizophrenia Sleep Sleep. Vigilance Vertebrates: nervous system and sense organs
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