Nicotine suppresses the P13 auditory evoked potential by acting on the pedunculopontine nucleus in the rat
We identified a potential novel site of action for nicotine (NIC) since (a) systemic injection of NIC led to a dose-dependent decrease in the amplitude of the sleep state-dependent, vertex-recorded, P13 midlatency auditory evoked potential (generated by the reticular activating system, RAS), (b) loc...
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| Veröffentlicht in: | Experimental brain research 2005-07, Vol.164 (1), p.109-119 |
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| creator | MAMIYA, N BUCHANAN, R WALLACE, T SKINNER, R. D GARCIA-RILL, E |
| description | We identified a potential novel site of action for nicotine (NIC) since (a) systemic injection of NIC led to a dose-dependent decrease in the amplitude of the sleep state-dependent, vertex-recorded, P13 midlatency auditory evoked potential (generated by the reticular activating system, RAS), (b) localized injections of a nicotinic receptor antagonist into the pedunculopontine nucleus (PPN, the cholinergic arm of the RAS) blocked the effects of systemic NIC on the P13 potential (a measure of level of arousal), and (c) localized injection of a nicotinic receptor agonist into the PPN also led to a decrease in the amplitude of the P13 potential, an effect blocked by PPN injection of a nicotinic receptor antagonist. There were minor changes in the manifestation of the startle response (SR) at the concentrations used; however, NIC did decrease the hippocampal N40 potential, although its effects were not affected by antagonist or agonist injections into the PPN. These results suggest a potential mechanism underlying the anxiolytic effects of NIC-suppression of the cholinergic arm of the RAS. |
| doi_str_mv | 10.1007/s00221-005-2219-8 |
| format | Article |
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D ; GARCIA-RILL, E</creator><creatorcontrib>MAMIYA, N ; BUCHANAN, R ; WALLACE, T ; SKINNER, R. D ; GARCIA-RILL, E</creatorcontrib><description>We identified a potential novel site of action for nicotine (NIC) since (a) systemic injection of NIC led to a dose-dependent decrease in the amplitude of the sleep state-dependent, vertex-recorded, P13 midlatency auditory evoked potential (generated by the reticular activating system, RAS), (b) localized injections of a nicotinic receptor antagonist into the pedunculopontine nucleus (PPN, the cholinergic arm of the RAS) blocked the effects of systemic NIC on the P13 potential (a measure of level of arousal), and (c) localized injection of a nicotinic receptor agonist into the PPN also led to a decrease in the amplitude of the P13 potential, an effect blocked by PPN injection of a nicotinic receptor antagonist. There were minor changes in the manifestation of the startle response (SR) at the concentrations used; however, NIC did decrease the hippocampal N40 potential, although its effects were not affected by antagonist or agonist injections into the PPN. These results suggest a potential mechanism underlying the anxiolytic effects of NIC-suppression of the cholinergic arm of the RAS.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s00221-005-2219-8</identifier><identifier>PMID: 15754179</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acoustic Stimulation ; Animals ; Anti-Anxiety Agents - pharmacology ; Arousal - drug effects ; Arousal - physiology ; Biological and medical sciences ; Cholinergic Fibers - drug effects ; Cholinergic Fibers - physiology ; Dose-Response Relationship, Drug ; Down-Regulation - drug effects ; Down-Regulation - physiology ; Electrodes ; Evoked Potentials, Auditory - drug effects ; Evoked Potentials, Auditory - physiology ; Fundamental and applied biological sciences. Psychology ; Male ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Neural Inhibition - drug effects ; Neural Inhibition - physiology ; Neural Pathways - drug effects ; Neural Pathways - physiology ; Neurosciences ; Nicotine ; Nicotine - pharmacology ; Nicotinic Agonists - pharmacology ; Nicotinic Antagonists - pharmacology ; Pedunculopontine Tegmental Nucleus - drug effects ; Pedunculopontine Tegmental Nucleus - physiology ; Rats ; Rats, Sprague-Dawley ; Reflex, Startle - drug effects ; Reflex, Startle - physiology ; Reticular Formation - drug effects ; Reticular Formation - physiology ; Schizophrenia ; Sleep ; Sleep. 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D</creatorcontrib><creatorcontrib>GARCIA-RILL, E</creatorcontrib><title>Nicotine suppresses the P13 auditory evoked potential by acting on the pedunculopontine nucleus in the rat</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>We identified a potential novel site of action for nicotine (NIC) since (a) systemic injection of NIC led to a dose-dependent decrease in the amplitude of the sleep state-dependent, vertex-recorded, P13 midlatency auditory evoked potential (generated by the reticular activating system, RAS), (b) localized injections of a nicotinic receptor antagonist into the pedunculopontine nucleus (PPN, the cholinergic arm of the RAS) blocked the effects of systemic NIC on the P13 potential (a measure of level of arousal), and (c) localized injection of a nicotinic receptor agonist into the PPN also led to a decrease in the amplitude of the P13 potential, an effect blocked by PPN injection of a nicotinic receptor antagonist. There were minor changes in the manifestation of the startle response (SR) at the concentrations used; however, NIC did decrease the hippocampal N40 potential, although its effects were not affected by antagonist or agonist injections into the PPN. These results suggest a potential mechanism underlying the anxiolytic effects of NIC-suppression of the cholinergic arm of the RAS.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Arousal - drug effects</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Cholinergic Fibers - drug effects</subject><subject>Cholinergic Fibers - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Down-Regulation - drug effects</subject><subject>Down-Regulation - physiology</subject><subject>Electrodes</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Neural Inhibition - drug effects</subject><subject>Neural Inhibition - physiology</subject><subject>Neural Pathways - drug effects</subject><subject>Neural Pathways - physiology</subject><subject>Neurosciences</subject><subject>Nicotine</subject><subject>Nicotine - pharmacology</subject><subject>Nicotinic Agonists - pharmacology</subject><subject>Nicotinic Antagonists - pharmacology</subject><subject>Pedunculopontine Tegmental Nucleus - drug effects</subject><subject>Pedunculopontine Tegmental Nucleus - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reflex, Startle - drug effects</subject><subject>Reflex, Startle - physiology</subject><subject>Reticular Formation - drug effects</subject><subject>Reticular Formation - physiology</subject><subject>Schizophrenia</subject><subject>Sleep</subject><subject>Sleep. 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D ; GARCIA-RILL, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-3f7a22d0afbdd895fd2864dc54e1a541dc15cf56add0624ba7eb9cb59f64c6ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Arousal - drug effects</topic><topic>Arousal - physiology</topic><topic>Biological and medical sciences</topic><topic>Cholinergic Fibers - drug effects</topic><topic>Cholinergic Fibers - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Down-Regulation - drug effects</topic><topic>Down-Regulation - physiology</topic><topic>Electrodes</topic><topic>Evoked Potentials, Auditory - drug effects</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Neural Inhibition - drug effects</topic><topic>Neural Inhibition - physiology</topic><topic>Neural Pathways - drug effects</topic><topic>Neural Pathways - physiology</topic><topic>Neurosciences</topic><topic>Nicotine</topic><topic>Nicotine - pharmacology</topic><topic>Nicotinic Agonists - pharmacology</topic><topic>Nicotinic Antagonists - pharmacology</topic><topic>Pedunculopontine Tegmental Nucleus - drug effects</topic><topic>Pedunculopontine Tegmental Nucleus - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reflex, Startle - drug effects</topic><topic>Reflex, Startle - physiology</topic><topic>Reticular Formation - drug effects</topic><topic>Reticular Formation - physiology</topic><topic>Schizophrenia</topic><topic>Sleep</topic><topic>Sleep. 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D</au><au>GARCIA-RILL, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicotine suppresses the P13 auditory evoked potential by acting on the pedunculopontine nucleus in the rat</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>164</volume><issue>1</issue><spage>109</spage><epage>119</epage><pages>109-119</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>We identified a potential novel site of action for nicotine (NIC) since (a) systemic injection of NIC led to a dose-dependent decrease in the amplitude of the sleep state-dependent, vertex-recorded, P13 midlatency auditory evoked potential (generated by the reticular activating system, RAS), (b) localized injections of a nicotinic receptor antagonist into the pedunculopontine nucleus (PPN, the cholinergic arm of the RAS) blocked the effects of systemic NIC on the P13 potential (a measure of level of arousal), and (c) localized injection of a nicotinic receptor agonist into the PPN also led to a decrease in the amplitude of the P13 potential, an effect blocked by PPN injection of a nicotinic receptor antagonist. There were minor changes in the manifestation of the startle response (SR) at the concentrations used; however, NIC did decrease the hippocampal N40 potential, although its effects were not affected by antagonist or agonist injections into the PPN. These results suggest a potential mechanism underlying the anxiolytic effects of NIC-suppression of the cholinergic arm of the RAS.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15754179</pmid><doi>10.1007/s00221-005-2219-8</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acoustic Stimulation Animals Anti-Anxiety Agents - pharmacology Arousal - drug effects Arousal - physiology Biological and medical sciences Cholinergic Fibers - drug effects Cholinergic Fibers - physiology Dose-Response Relationship, Drug Down-Regulation - drug effects Down-Regulation - physiology Electrodes Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Fundamental and applied biological sciences. Psychology Male Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Neural Inhibition - drug effects Neural Inhibition - physiology Neural Pathways - drug effects Neural Pathways - physiology Neurosciences Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Pedunculopontine Tegmental Nucleus - drug effects Pedunculopontine Tegmental Nucleus - physiology Rats Rats, Sprague-Dawley Reflex, Startle - drug effects Reflex, Startle - physiology Reticular Formation - drug effects Reticular Formation - physiology Schizophrenia Sleep Sleep. Vigilance Vertebrates: nervous system and sense organs |
| title | Nicotine suppresses the P13 auditory evoked potential by acting on the pedunculopontine nucleus in the rat |
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