Genetics and biology of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of
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| Veröffentlicht in: | Genes & development 2006-05, Vol.20 (10), p.1218-1249 |
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| container_issue | 10 |
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| container_title | Genes & development |
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| creator | Hezel, Aram F Kimmelman, Alec C Stanger, Ben Z Bardeesy, Nabeel Depinho, Ronald A |
| description | Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of |
| doi_str_mv | 10.1101/gad.1415606 |
| format | Article |
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The cancer's lethal nature stems from its propensity to rapidly disseminate to the lymphatic system and distant organs. This aggressive biology and resistance to conventional and targeted therapeutic agents leads to a typical clinical presentation of incurable disease at the time of diagnosis. The well-defined serial histopathologic picture and accompanying molecular profiles of PDAC and its precursor lesions have provided the framework for emerging basic and translational research. Recent advances include insights into the cancer's cellular origins, high-resolution genomic profiles pointing to potential new therapeutic targets, and refined mouse models reflecting both the genetics and histopathologic evolution of human PDAC. 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This confluence of developments offers the opportunity for accelerated discovery and the future promise of improved treatment.</description><subject>Animals</subject><subject>Carcinoma, Pancreatic Ductal - genetics</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Pancreas - anatomy & histology</subject><subject>Pancreas - pathology</subject><subject>Pancreas - physiology</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - pathology</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAUhS0EoqUwsaNMLCjlOn7FI6p4SZVYYLb8rIKSuNjJ0H9PqkZiZLlnuJ_OkT6EbjGsMQb8uNNujSlmHPgZWmJGZcmoEOdoCbWEUhIuF-gq528AmBh-iRaYC6gowBLVr773Q2NzoXtXmCa2cXcoYij2urfJ6-lVuNEOui208320Otmmj52-RhdBt9nfzLlCXy_Pn5u3cvvx-r552paW1HQouROWW8ywny43EOxx1xhtKVRYkkC5JNobiwMxFeeBCcOkr4zzdQUykBW6P_XuU_wZfR5U12Tr21b3Po5ZcSEFMAL_glhUpOY1m8CHE2hTzDn5oPap6XQ6KAzqaFRNRtVsdKLv5trRdN79sbNC8gu3xXBx</recordid><startdate>20060515</startdate><enddate>20060515</enddate><creator>Hezel, Aram F</creator><creator>Kimmelman, Alec C</creator><creator>Stanger, Ben Z</creator><creator>Bardeesy, Nabeel</creator><creator>Depinho, Ronald A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060515</creationdate><title>Genetics and biology of pancreatic ductal adenocarcinoma</title><author>Hezel, Aram F ; Kimmelman, Alec C ; Stanger, Ben Z ; Bardeesy, Nabeel ; Depinho, Ronald A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-6d7c6c151e6c16b0fc2400bbac402193f4693aebc1f3b266f57b59e2bde8209f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Carcinoma, Pancreatic Ductal - genetics</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Pancreas - anatomy & histology</topic><topic>Pancreas - pathology</topic><topic>Pancreas - physiology</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hezel, Aram F</creatorcontrib><creatorcontrib>Kimmelman, Alec C</creatorcontrib><creatorcontrib>Stanger, Ben Z</creatorcontrib><creatorcontrib>Bardeesy, Nabeel</creatorcontrib><creatorcontrib>Depinho, Ronald A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hezel, Aram F</au><au>Kimmelman, Alec C</au><au>Stanger, Ben Z</au><au>Bardeesy, Nabeel</au><au>Depinho, Ronald A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetics and biology of pancreatic ductal adenocarcinoma</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>2006-05-15</date><risdate>2006</risdate><volume>20</volume><issue>10</issue><spage>1218</spage><epage>1249</epage><pages>1218-1249</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of <6 mo and a dismal 5-yr survival rate of 3%-5%. 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| fulltext | fulltext |
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| ispartof | Genes & development, 2006-05, Vol.20 (10), p.1218-1249 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Disease Models, Animal Humans Mice Mice, Mutant Strains Pancreas - anatomy & histology Pancreas - pathology Pancreas - physiology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology |
| title | Genetics and biology of pancreatic ductal adenocarcinoma |
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