Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose

It was reported that connective tissue growth factor (CTGF) was expressed in the tubular epithelial cells of the diabetic kidney. CTGF has, among other factors, been implicated in mediating the downstream, profibrotic effects of transforming growth factor-beta (TGF-beta), though is precise role in i...

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Veröffentlicht in:	Clinical and experimental nephrology 2005-06, Vol.9 (2), p.114-121
Hauptverfasser:	Kobayashi, Tatsuya, Inoue, Tsutomu, Okada, Hirokazu, Kikuta, Tomohiro, Kanno, Yoshihiko, Nishida, Takashi, Takigawa, Masaharu, Sugaya, Takeshi, Suzuki, Hiromichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Coculture Techniques Connective Tissue Growth Factor Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology Epithelial Cells - drug effects Epithelial Cells - pathology Epithelial Cells - physiology Fibroblasts - cytology Fibrosis Gene Expression - drug effects Gene Expression - physiology Glucose - pharmacology Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - metabolism Mice Transforming Growth Factor beta - metabolism
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