Overview of the Diagnosis and Management of Diabetic Ketoacidosis
Diabetic ketoacidosis is an acute complication of diabetes mellitus that can be life-threatening if not treated properly. Once thought to occur only in patients with type 1 diabetes, diabetic ketoacidosis has been also observed in patients with type 2 diabetes under certain conditions. The basic und...
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| Veröffentlicht in: | The American journal of the medical sciences 2006-05, Vol.331 (5), p.243-251 |
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| container_title | The American journal of the medical sciences |
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| creator | Eledrisi, Mohsen S. Alshanti, Mohammed S. Faiq Shah, M. Brolosy, Basem Jaha, Nermeen |
| description | Diabetic ketoacidosis is an acute complication of diabetes mellitus that can be life-threatening if not treated properly. Once thought to occur only in patients with type 1 diabetes, diabetic ketoacidosis has been also observed in patients with type 2 diabetes under certain conditions. The basic underlying mechanism for diabetic ketoacidosis is insulin deficiency coupled with elevated levels of counter-regulatory hormones, such as glucagon, cortisol, catecholamines, and growth hormone. Diabetic ketoacidosis can be the initial presentation of diabetes mellitus or precipitated in known diabetic patients by many factors, most commonly infection. The management of diabetic ketoacidosis involves careful clinical evaluation, correction of metabolic abnormalities, identification and treatment of precipitating and comorbid conditions, appropriate long-term treatment of diabetes, and plans to prevent recurrence. Certain areas need further research, such as indications for the use of bicarbonate and phosphates and the use of intravenous rapid-acting insulin. |
| doi_str_mv | 10.1097/00000441-200605000-00002 |
| format | Article |
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Once thought to occur only in patients with type 1 diabetes, diabetic ketoacidosis has been also observed in patients with type 2 diabetes under certain conditions. The basic underlying mechanism for diabetic ketoacidosis is insulin deficiency coupled with elevated levels of counter-regulatory hormones, such as glucagon, cortisol, catecholamines, and growth hormone. Diabetic ketoacidosis can be the initial presentation of diabetes mellitus or precipitated in known diabetic patients by many factors, most commonly infection. The management of diabetic ketoacidosis involves careful clinical evaluation, correction of metabolic abnormalities, identification and treatment of precipitating and comorbid conditions, appropriate long-term treatment of diabetes, and plans to prevent recurrence. 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Once thought to occur only in patients with type 1 diabetes, diabetic ketoacidosis has been also observed in patients with type 2 diabetes under certain conditions. The basic underlying mechanism for diabetic ketoacidosis is insulin deficiency coupled with elevated levels of counter-regulatory hormones, such as glucagon, cortisol, catecholamines, and growth hormone. Diabetic ketoacidosis can be the initial presentation of diabetes mellitus or precipitated in known diabetic patients by many factors, most commonly infection. The management of diabetic ketoacidosis involves careful clinical evaluation, correction of metabolic abnormalities, identification and treatment of precipitating and comorbid conditions, appropriate long-term treatment of diabetes, and plans to prevent recurrence. 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Target tissue resistance</subject><subject>Fluid management</subject><subject>Fluid Therapy</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin</subject><subject>Insulin - therapeutic use</subject><subject>Ketoacidosis</subject><subject>Medical sciences</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PAyEQhonR2Fr9C2YvelsFdpePY62fsaYXPRMWhoppdytsa_z3srbqUS6Ed56ZIQ9CGcEXBEt-iftTliSnGDNcpUfeJ3QPDUlViJxKiffRsI9yyagcoKMY3zAmVJDiEA0I45hyWQzReLaBsPHwkbUu614hu_Z63rTRx0w3NnvSjZ7DEpqur6daDZ032SN0rTbe9twxOnB6EeFkd4_Qy-3N8-Q-n87uHibjaW5KJrpcm7RTlJgY4rjlGmoHJZGY6ZpVVJbGOmYLrgXDIEqpKyutrCkjjrlKClyM0Pl27iq072uInVr6aGCx0A2066gYl0zIqkqg2IImtDEGcGoV_FKHT0Ww6vWpH33qV993RFPr6W7Hul6C_Wvc-UrA2Q7Q0eiFC7oxPv5xnIuKiTJxV1sOkpGkN6hoPDQGrA9gOmVb__9vvgBuFYqu</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Eledrisi, Mohsen S.</creator><creator>Alshanti, Mohammed S.</creator><creator>Faiq Shah, M.</creator><creator>Brolosy, Basem</creator><creator>Jaha, Nermeen</creator><general>Elsevier Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Overview of the Diagnosis and Management of Diabetic Ketoacidosis</title><author>Eledrisi, Mohsen S. ; Alshanti, Mohammed S. ; Faiq Shah, M. ; Brolosy, Basem ; Jaha, Nermeen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-ac6708401c1f7d7aebfe41906ab65294cdf6d37a860e849a5d9d9b261f6f59803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acid-Base Equilibrium - physiology</topic><topic>Bicarbonates - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes</topic><topic>Diabetes. 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| subjects | Acid-Base Equilibrium - physiology Bicarbonates - therapeutic use Biological and medical sciences Blood Glucose - analysis Diabetes Diabetes. Impaired glucose tolerance Diabetic Ketoacidosis - diagnosis Diabetic Ketoacidosis - physiopathology Diabetic Ketoacidosis - therapy Electrolytes - therapeutic use Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fluid management Fluid Therapy General aspects Humans Hypoglycemic Agents - therapeutic use Insulin Insulin - therapeutic use Ketoacidosis Medical sciences |
| title | Overview of the Diagnosis and Management of Diabetic Ketoacidosis |
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