Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure
Abstract Background: Sudden death is common in chronic heart failure (CHF). Risk stratification is the first step for primary prevention. Aim: To evaluate the use of risk markers for estimating sudden death risk. Methods and results: We prospectively examined 680 stable patients with CHF. Risk marke...
Gespeichert in:
| Veröffentlicht in: | European journal of heart failure 2006-05, Vol.8 (3), p.237-242 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 242 |
|---|---|
| container_issue | 3 |
| container_start_page | 237 |
| container_title | European journal of heart failure |
| container_volume | 8 |
| creator | Watanabe, Jun Shinozaki, Tsuyoshi Shiba, Nobuyuki Fukahori, Kohei Koseki, Yoshito Karibe, Akihiko Sakuma, Masahito Miura, Masahito Kagaya, Yutaka Shirato, Kunio |
| description | Abstract
Background:
Sudden death is common in chronic heart failure (CHF). Risk stratification is the first step for primary prevention.
Aim:
To evaluate the use of risk markers for estimating sudden death risk.
Methods and results:
We prospectively examined 680 stable patients with CHF. Risk markers were evaluated using the Cox's proportional hazard model in a stepwise manner. Ejection fraction 60 mm, brain natriuretic peptide >200 pg/ml, non-sustained ventricular tachycardia, and diabetes were significantly associated with increased risk of sudden death. When the number of risk markers were included as co-variables, only "number of risk markers ≥3" entered the model (hazard ratio 8.95, 95% confidence interval 4.57-17.52), while the effects of individual markers did not enter the model. The annual mortality from sudden death was 11% in patients with 3 or more risk markers and 1.4% in patients with 2 or less.
Conclusions:
Rather than particular risk markers, the number of accumulated risk markers was a more powerful predictor for sudden death in patients with CHF. The number of risk markers could be useful for risk stratification of sudden death. |
| doi_str_mv | 10.1016/j.ejheart.2005.08.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67967886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1016/j.ejheart.2005.08.003</oup_id><sourcerecordid>67967886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3753-932251c7d94f2c3076b5e046b96cebfc72664e73cb5a1bb50d138185464f3013</originalsourceid><addsrcrecordid>eNqNUU1P3DAQtRBVobQ_AeQTt4Rx7NjOkSLYLUL9kJDozUqcidYhm6R2IuDf421WVL1x8sjz3pt5bwg5ZZAyYPKiTbHdYOmnNAPIU9ApAD8gx0yrIgEtxGGsudZJoUV2RD6F0AIwBZB9JEdMMp0XmTgm7aW183buyskNPR0a6l14pNvSP6IPdPRYOzsFOm2Qut66GnuLO1iY61jTGstpEzt0jALYR-STix9244feWfp3QdqUrps9fiYfmrIL-GX_npD7m-v7q3Vy92P17eryLrFc5TwpeJblzKq6EE1mOShZ5QhCVoW0WDVWZVIKVNxWecmqKoc62ox2hBQNB8ZPyPkiO_rhz4xhMlsXLHZd2eMwByNVIZXWMgLzBWj9EILHxozeRecvhoHZZWxas8_Y7DI2oE3MOPLO9gPmaov1P9Y-1Aj4ugCeXIcv71M117frm_-nwCIyzOO7F0sWigsTPr-R4i2j6Zitefi-Mr_WbPWbwU_zwF8Bq5auQg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67967886</pqid></control><display><type>article</type><title>Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Watanabe, Jun ; Shinozaki, Tsuyoshi ; Shiba, Nobuyuki ; Fukahori, Kohei ; Koseki, Yoshito ; Karibe, Akihiko ; Sakuma, Masahito ; Miura, Masahito ; Kagaya, Yutaka ; Shirato, Kunio</creator><creatorcontrib>Watanabe, Jun ; Shinozaki, Tsuyoshi ; Shiba, Nobuyuki ; Fukahori, Kohei ; Koseki, Yoshito ; Karibe, Akihiko ; Sakuma, Masahito ; Miura, Masahito ; Kagaya, Yutaka ; Shirato, Kunio</creatorcontrib><description>Abstract
Background:
Sudden death is common in chronic heart failure (CHF). Risk stratification is the first step for primary prevention.
Aim:
To evaluate the use of risk markers for estimating sudden death risk.
Methods and results:
We prospectively examined 680 stable patients with CHF. Risk markers were evaluated using the Cox's proportional hazard model in a stepwise manner. Ejection fraction <30%, left ventricular end-diastolic diameter >60 mm, brain natriuretic peptide >200 pg/ml, non-sustained ventricular tachycardia, and diabetes were significantly associated with increased risk of sudden death. When the number of risk markers were included as co-variables, only "number of risk markers ≥3" entered the model (hazard ratio 8.95, 95% confidence interval 4.57-17.52), while the effects of individual markers did not enter the model. The annual mortality from sudden death was 11% in patients with 3 or more risk markers and 1.4% in patients with 2 or less.
Conclusions:
Rather than particular risk markers, the number of accumulated risk markers was a more powerful predictor for sudden death in patients with CHF. The number of risk markers could be useful for risk stratification of sudden death.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1016/j.ejheart.2005.08.003</identifier><identifier>PMID: 16185924</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; brain natriuretic peptide ; Death, Sudden - etiology ; Diastole ; ejection fraction ; Female ; heart failure ; Heart Failure - complications ; Heart Failure - physiopathology ; Humans ; Incidence ; Male ; Middle Aged ; observational study ; Prospective Studies ; Risk ; risk markers ; Stroke Volume ; Ventricular Function, Left</subject><ispartof>European journal of heart failure, 2006-05, Vol.8 (3), p.237-242</ispartof><rights>2005 European Society of Cardiology 2005</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © 2006 the Authors</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3753-932251c7d94f2c3076b5e046b96cebfc72664e73cb5a1bb50d138185464f3013</citedby><cites>FETCH-LOGICAL-c3753-932251c7d94f2c3076b5e046b96cebfc72664e73cb5a1bb50d138185464f3013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ejheart.2005.08.003$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ejheart.2005.08.003$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16185924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Jun</creatorcontrib><creatorcontrib>Shinozaki, Tsuyoshi</creatorcontrib><creatorcontrib>Shiba, Nobuyuki</creatorcontrib><creatorcontrib>Fukahori, Kohei</creatorcontrib><creatorcontrib>Koseki, Yoshito</creatorcontrib><creatorcontrib>Karibe, Akihiko</creatorcontrib><creatorcontrib>Sakuma, Masahito</creatorcontrib><creatorcontrib>Miura, Masahito</creatorcontrib><creatorcontrib>Kagaya, Yutaka</creatorcontrib><creatorcontrib>Shirato, Kunio</creatorcontrib><title>Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure</title><title>European journal of heart failure</title><addtitle>European Journal of Heart Failure</addtitle><description>Abstract
Background:
Sudden death is common in chronic heart failure (CHF). Risk stratification is the first step for primary prevention.
Aim:
To evaluate the use of risk markers for estimating sudden death risk.
Methods and results:
We prospectively examined 680 stable patients with CHF. Risk markers were evaluated using the Cox's proportional hazard model in a stepwise manner. Ejection fraction <30%, left ventricular end-diastolic diameter >60 mm, brain natriuretic peptide >200 pg/ml, non-sustained ventricular tachycardia, and diabetes were significantly associated with increased risk of sudden death. When the number of risk markers were included as co-variables, only "number of risk markers ≥3" entered the model (hazard ratio 8.95, 95% confidence interval 4.57-17.52), while the effects of individual markers did not enter the model. The annual mortality from sudden death was 11% in patients with 3 or more risk markers and 1.4% in patients with 2 or less.
Conclusions:
Rather than particular risk markers, the number of accumulated risk markers was a more powerful predictor for sudden death in patients with CHF. The number of risk markers could be useful for risk stratification of sudden death.</description><subject>Adult</subject><subject>Aged</subject><subject>brain natriuretic peptide</subject><subject>Death, Sudden - etiology</subject><subject>Diastole</subject><subject>ejection fraction</subject><subject>Female</subject><subject>heart failure</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>observational study</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>risk markers</subject><subject>Stroke Volume</subject><subject>Ventricular Function, Left</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1P3DAQtRBVobQ_AeQTt4Rx7NjOkSLYLUL9kJDozUqcidYhm6R2IuDf421WVL1x8sjz3pt5bwg5ZZAyYPKiTbHdYOmnNAPIU9ApAD8gx0yrIgEtxGGsudZJoUV2RD6F0AIwBZB9JEdMMp0XmTgm7aW183buyskNPR0a6l14pNvSP6IPdPRYOzsFOm2Qut66GnuLO1iY61jTGstpEzt0jALYR-STix9244feWfp3QdqUrps9fiYfmrIL-GX_npD7m-v7q3Vy92P17eryLrFc5TwpeJblzKq6EE1mOShZ5QhCVoW0WDVWZVIKVNxWecmqKoc62ox2hBQNB8ZPyPkiO_rhz4xhMlsXLHZd2eMwByNVIZXWMgLzBWj9EILHxozeRecvhoHZZWxas8_Y7DI2oE3MOPLO9gPmaov1P9Y-1Aj4ugCeXIcv71M117frm_-nwCIyzOO7F0sWigsTPr-R4i2j6Zitefi-Mr_WbPWbwU_zwF8Bq5auQg</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Watanabe, Jun</creator><creator>Shinozaki, Tsuyoshi</creator><creator>Shiba, Nobuyuki</creator><creator>Fukahori, Kohei</creator><creator>Koseki, Yoshito</creator><creator>Karibe, Akihiko</creator><creator>Sakuma, Masahito</creator><creator>Miura, Masahito</creator><creator>Kagaya, Yutaka</creator><creator>Shirato, Kunio</creator><general>Blackwell Publishing Ltd</general><general>Elsevier</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure</title><author>Watanabe, Jun ; Shinozaki, Tsuyoshi ; Shiba, Nobuyuki ; Fukahori, Kohei ; Koseki, Yoshito ; Karibe, Akihiko ; Sakuma, Masahito ; Miura, Masahito ; Kagaya, Yutaka ; Shirato, Kunio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3753-932251c7d94f2c3076b5e046b96cebfc72664e73cb5a1bb50d138185464f3013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>brain natriuretic peptide</topic><topic>Death, Sudden - etiology</topic><topic>Diastole</topic><topic>ejection fraction</topic><topic>Female</topic><topic>heart failure</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>observational study</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>risk markers</topic><topic>Stroke Volume</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, Jun</creatorcontrib><creatorcontrib>Shinozaki, Tsuyoshi</creatorcontrib><creatorcontrib>Shiba, Nobuyuki</creatorcontrib><creatorcontrib>Fukahori, Kohei</creatorcontrib><creatorcontrib>Koseki, Yoshito</creatorcontrib><creatorcontrib>Karibe, Akihiko</creatorcontrib><creatorcontrib>Sakuma, Masahito</creatorcontrib><creatorcontrib>Miura, Masahito</creatorcontrib><creatorcontrib>Kagaya, Yutaka</creatorcontrib><creatorcontrib>Shirato, Kunio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of heart failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Jun</au><au>Shinozaki, Tsuyoshi</au><au>Shiba, Nobuyuki</au><au>Fukahori, Kohei</au><au>Koseki, Yoshito</au><au>Karibe, Akihiko</au><au>Sakuma, Masahito</au><au>Miura, Masahito</au><au>Kagaya, Yutaka</au><au>Shirato, Kunio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure</atitle><jtitle>European journal of heart failure</jtitle><addtitle>European Journal of Heart Failure</addtitle><date>2006-05</date><risdate>2006</risdate><volume>8</volume><issue>3</issue><spage>237</spage><epage>242</epage><pages>237-242</pages><issn>1388-9842</issn><eissn>1879-0844</eissn><abstract>Abstract
Background:
Sudden death is common in chronic heart failure (CHF). Risk stratification is the first step for primary prevention.
Aim:
To evaluate the use of risk markers for estimating sudden death risk.
Methods and results:
We prospectively examined 680 stable patients with CHF. Risk markers were evaluated using the Cox's proportional hazard model in a stepwise manner. Ejection fraction <30%, left ventricular end-diastolic diameter >60 mm, brain natriuretic peptide >200 pg/ml, non-sustained ventricular tachycardia, and diabetes were significantly associated with increased risk of sudden death. When the number of risk markers were included as co-variables, only "number of risk markers ≥3" entered the model (hazard ratio 8.95, 95% confidence interval 4.57-17.52), while the effects of individual markers did not enter the model. The annual mortality from sudden death was 11% in patients with 3 or more risk markers and 1.4% in patients with 2 or less.
Conclusions:
Rather than particular risk markers, the number of accumulated risk markers was a more powerful predictor for sudden death in patients with CHF. The number of risk markers could be useful for risk stratification of sudden death.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>16185924</pmid><doi>10.1016/j.ejheart.2005.08.003</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1388-9842 |
| ispartof | European journal of heart failure, 2006-05, Vol.8 (3), p.237-242 |
| issn | 1388-9842 1879-0844 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67967886 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged brain natriuretic peptide Death, Sudden - etiology Diastole ejection fraction Female heart failure Heart Failure - complications Heart Failure - physiopathology Humans Incidence Male Middle Aged observational study Prospective Studies Risk risk markers Stroke Volume Ventricular Function, Left |
| title | Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T13%3A53%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Accumulation%20of%20risk%20markers%20predicts%20the%20incidence%20of%20sudden%20death%20in%20patients%20with%20chronic%20heart%20failure&rft.jtitle=European%20journal%20of%20heart%20failure&rft.au=Watanabe,%20Jun&rft.date=2006-05&rft.volume=8&rft.issue=3&rft.spage=237&rft.epage=242&rft.pages=237-242&rft.issn=1388-9842&rft.eissn=1879-0844&rft_id=info:doi/10.1016/j.ejheart.2005.08.003&rft_dat=%3Cproquest_cross%3E67967886%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67967886&rft_id=info:pmid/16185924&rft_oup_id=10.1016/j.ejheart.2005.08.003&rfr_iscdi=true |