Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines

Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g...

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Veröffentlicht in:British journal of nutrition 2005-05, Vol.93 (5), p.747-754
Hauptverfasser: Chen, Qixuan, Li, Edmund T. S.
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description Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7·5 g/kg or 0·75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P
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S.</creator><creatorcontrib>Chen, Qixuan ; Li, Edmund T. S.</creatorcontrib><description>Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7·5 g/kg or 0·75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P&lt;0·05) and steatosis score (P&lt;0·05) similar to those in rats fed a low-fat diet. BM supplementation did not affect serum and hepatic cholesterol. However, plasma epinephrine and serum free fatty acid concentrations were increased (P&lt;0·05). In the third experiment, BM(7·5 and 15 g/kg) and 1·5 % BM lowered triacylglycerol concentration in red gastrocnemius and tibialis anterior (P&lt;0·05) muscle, but a dose–response effect was not observed. These data suggest that chronic BM feeding leads to a general decrease in tissue fat accumulation and that such an effect is mediated in part by enhanced sympathetic activity and lipolysis. BM or its bioactive ingredient(s) could be used as a dietary adjunct in the control of body weight and blood glucose.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN20051388</identifier><identifier>PMID: 15975176</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>adipocytes ; Adiposity ; Animal Feed ; animal models ; Animals ; Biological and medical sciences ; Bitter melon ; Blood Glucose - analysis ; Body weight ; Catecholamines ; Catecholamines - blood ; cholesteremic effect ; Cucurbitaceae ; Diet ; Dietary Supplements ; Dose-response effects ; Energy efficiency ; experimental diets ; Fatty acids ; Fatty Liver - metabolism ; Fatty Liver - pathology ; Feeding. Feeding behavior ; Female ; free fatty acids ; Fundamental and applied biological sciences. Psychology ; glycemic effect ; gourds ; lipolysis ; liver ; Liver - chemistry ; Liver - pathology ; Male ; medicinal plants ; Models, Animal ; Momordica charantia ; Muscle, Skeletal - chemistry ; Obesity - metabolism ; Obesity - pathology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; traditional medicine ; Triacylglycerol ; triacylglycerols ; Triglycerides - analysis ; Triglycerides - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2005-05, Vol.93 (5), p.747-754</ispartof><rights>Copyright © The Nutrition Society 2005</rights><rights>2005 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-faccd972bb0809a5c630782b6b57feac24866e5dd34f1fc132bc3ae340a33e683</citedby><cites>FETCH-LOGICAL-c481t-faccd972bb0809a5c630782b6b57feac24866e5dd34f1fc132bc3ae340a33e683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=16940043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15975176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Qixuan</creatorcontrib><creatorcontrib>Li, Edmund T. S.</creatorcontrib><title>Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7·5 g/kg or 0·75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P&lt;0·05) and steatosis score (P&lt;0·05) similar to those in rats fed a low-fat diet. BM supplementation did not affect serum and hepatic cholesterol. However, plasma epinephrine and serum free fatty acid concentrations were increased (P&lt;0·05). In the third experiment, BM(7·5 and 15 g/kg) and 1·5 % BM lowered triacylglycerol concentration in red gastrocnemius and tibialis anterior (P&lt;0·05) muscle, but a dose–response effect was not observed. These data suggest that chronic BM feeding leads to a general decrease in tissue fat accumulation and that such an effect is mediated in part by enhanced sympathetic activity and lipolysis. BM or its bioactive ingredient(s) could be used as a dietary adjunct in the control of body weight and blood glucose.</description><subject>adipocytes</subject><subject>Adiposity</subject><subject>Animal Feed</subject><subject>animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bitter melon</subject><subject>Blood Glucose - analysis</subject><subject>Body weight</subject><subject>Catecholamines</subject><subject>Catecholamines - blood</subject><subject>cholesteremic effect</subject><subject>Cucurbitaceae</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Dose-response effects</subject><subject>Energy efficiency</subject><subject>experimental diets</subject><subject>Fatty acids</subject><subject>Fatty Liver - metabolism</subject><subject>Fatty Liver - pathology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>free fatty acids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glycemic effect</subject><subject>gourds</subject><subject>lipolysis</subject><subject>liver</subject><subject>Liver - chemistry</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>medicinal plants</subject><subject>Models, Animal</subject><subject>Momordica charantia</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Obesity - metabolism</subject><subject>Obesity - pathology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>traditional medicine</subject><subject>Triacylglycerol</subject><subject>triacylglycerols</subject><subject>Triglycerides - analysis</subject><subject>Triglycerides - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU9v1DAQxS0EotvCiTtYSEUgFLDj-E-OUNGFagFB6dmaOM7GJYkX21HZL8FnxtWuWIQ4WeP5zdObeQg9ouQVJbJ-_fbiU0kIp0ypO2hBK8mLUojyLloQQmRBacWP0HGM17lUlNT30RHlteRUigX69dW2s7EthtZtfHRpi92EG5eSDXi0g5_w849-9KF1BrDpIcCUHLzAXZ4JkCJ2EUOM3jhI-evGpR4P_iZPJxfjbHEKbj1sjQ2utRimFvdu3ef2ZoA4Zsk8Zno_wOgmGx-gex0M0T7cvyfo6vzdt7P3xerz8sPZm1VhKkVT0YExbS3LpiGK1MCNYESqshENl50FU1ZKCMvbllUd7QxlZWMYWFYRYMwKxU7Qs53uJvgfs41Jjy4aOwwwWT9HLWQtBKUsg0__Aa_9HKbsTZf54oznq2fo5Q4ywccYbKc3wY0QtpoSfZuR_iujTD_eS87NaNsDuw8lA6d7AKKBocsnNy4eOFFXhFS33ood52KyP__0IXzP_pnkWiy_6KUi8nx1eaHrzD_Z8R14DeuQNa8uS0IZoYTWqlQHRQNjkwNb28O6_1vlNzHTwTw</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Chen, Qixuan</creator><creator>Li, Edmund T. 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S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-faccd972bb0809a5c630782b6b57feac24866e5dd34f1fc132bc3ae340a33e683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>adipocytes</topic><topic>Adiposity</topic><topic>Animal Feed</topic><topic>animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bitter melon</topic><topic>Blood Glucose - analysis</topic><topic>Body weight</topic><topic>Catecholamines</topic><topic>Catecholamines - blood</topic><topic>cholesteremic effect</topic><topic>Cucurbitaceae</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Dose-response effects</topic><topic>Energy efficiency</topic><topic>experimental diets</topic><topic>Fatty acids</topic><topic>Fatty Liver - metabolism</topic><topic>Fatty Liver - pathology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>free fatty acids</topic><topic>Fundamental and applied biological sciences. 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S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>93</volume><issue>5</issue><spage>747</spage><epage>754</epage><pages>747-754</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7·5 g/kg or 0·75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P&lt;0·05) and steatosis score (P&lt;0·05) similar to those in rats fed a low-fat diet. BM supplementation did not affect serum and hepatic cholesterol. However, plasma epinephrine and serum free fatty acid concentrations were increased (P&lt;0·05). In the third experiment, BM(7·5 and 15 g/kg) and 1·5 % BM lowered triacylglycerol concentration in red gastrocnemius and tibialis anterior (P&lt;0·05) muscle, but a dose–response effect was not observed. These data suggest that chronic BM feeding leads to a general decrease in tissue fat accumulation and that such an effect is mediated in part by enhanced sympathetic activity and lipolysis. BM or its bioactive ingredient(s) could be used as a dietary adjunct in the control of body weight and blood glucose.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>15975176</pmid><doi>10.1079/BJN20051388</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects adipocytes
Adiposity
Animal Feed
animal models
Animals
Biological and medical sciences
Bitter melon
Blood Glucose - analysis
Body weight
Catecholamines
Catecholamines - blood
cholesteremic effect
Cucurbitaceae
Diet
Dietary Supplements
Dose-response effects
Energy efficiency
experimental diets
Fatty acids
Fatty Liver - metabolism
Fatty Liver - pathology
Feeding. Feeding behavior
Female
free fatty acids
Fundamental and applied biological sciences. Psychology
glycemic effect
gourds
lipolysis
liver
Liver - chemistry
Liver - pathology
Male
medicinal plants
Models, Animal
Momordica charantia
Muscle, Skeletal - chemistry
Obesity - metabolism
Obesity - pathology
Random Allocation
Rats
Rats, Sprague-Dawley
traditional medicine
Triacylglycerol
triacylglycerols
Triglycerides - analysis
Triglycerides - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines
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