Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines
Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g...
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description | Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7·5 g/kg or 0·75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P |
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S.</creator><creatorcontrib>Chen, Qixuan ; Li, Edmund T. S.</creatorcontrib><description>Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7·5 g/kg or 0·75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P<0·05) and steatosis score (P<0·05) similar to those in rats fed a low-fat diet. BM supplementation did not affect serum and hepatic cholesterol. However, plasma epinephrine and serum free fatty acid concentrations were increased (P<0·05). In the third experiment, BM(7·5 and 15 g/kg) and 1·5 % BM lowered triacylglycerol concentration in red gastrocnemius and tibialis anterior (P<0·05) muscle, but a dose–response effect was not observed. These data suggest that chronic BM feeding leads to a general decrease in tissue fat accumulation and that such an effect is mediated in part by enhanced sympathetic activity and lipolysis. BM or its bioactive ingredient(s) could be used as a dietary adjunct in the control of body weight and blood glucose.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN20051388</identifier><identifier>PMID: 15975176</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>adipocytes ; Adiposity ; Animal Feed ; animal models ; Animals ; Biological and medical sciences ; Bitter melon ; Blood Glucose - analysis ; Body weight ; Catecholamines ; Catecholamines - blood ; cholesteremic effect ; Cucurbitaceae ; Diet ; Dietary Supplements ; Dose-response effects ; Energy efficiency ; experimental diets ; Fatty acids ; Fatty Liver - metabolism ; Fatty Liver - pathology ; Feeding. Feeding behavior ; Female ; free fatty acids ; Fundamental and applied biological sciences. Psychology ; glycemic effect ; gourds ; lipolysis ; liver ; Liver - chemistry ; Liver - pathology ; Male ; medicinal plants ; Models, Animal ; Momordica charantia ; Muscle, Skeletal - chemistry ; Obesity - metabolism ; Obesity - pathology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; traditional medicine ; Triacylglycerol ; triacylglycerols ; Triglycerides - analysis ; Triglycerides - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2005-05, Vol.93 (5), p.747-754</ispartof><rights>Copyright © The Nutrition Society 2005</rights><rights>2005 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-faccd972bb0809a5c630782b6b57feac24866e5dd34f1fc132bc3ae340a33e683</citedby><cites>FETCH-LOGICAL-c481t-faccd972bb0809a5c630782b6b57feac24866e5dd34f1fc132bc3ae340a33e683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16940043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15975176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Qixuan</creatorcontrib><creatorcontrib>Li, Edmund T. S.</creatorcontrib><title>Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7·5 g/kg or 0·75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P<0·05) and steatosis score (P<0·05) similar to those in rats fed a low-fat diet. BM supplementation did not affect serum and hepatic cholesterol. However, plasma epinephrine and serum free fatty acid concentrations were increased (P<0·05). In the third experiment, BM(7·5 and 15 g/kg) and 1·5 % BM lowered triacylglycerol concentration in red gastrocnemius and tibialis anterior (P<0·05) muscle, but a dose–response effect was not observed. These data suggest that chronic BM feeding leads to a general decrease in tissue fat accumulation and that such an effect is mediated in part by enhanced sympathetic activity and lipolysis. BM or its bioactive ingredient(s) could be used as a dietary adjunct in the control of body weight and blood glucose.</description><subject>adipocytes</subject><subject>Adiposity</subject><subject>Animal Feed</subject><subject>animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bitter melon</subject><subject>Blood Glucose - analysis</subject><subject>Body weight</subject><subject>Catecholamines</subject><subject>Catecholamines - blood</subject><subject>cholesteremic effect</subject><subject>Cucurbitaceae</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Dose-response effects</subject><subject>Energy efficiency</subject><subject>experimental diets</subject><subject>Fatty acids</subject><subject>Fatty Liver - metabolism</subject><subject>Fatty Liver - pathology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>free fatty acids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glycemic effect</subject><subject>gourds</subject><subject>lipolysis</subject><subject>liver</subject><subject>Liver - chemistry</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>medicinal plants</subject><subject>Models, Animal</subject><subject>Momordica charantia</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Obesity - metabolism</subject><subject>Obesity - pathology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>traditional medicine</subject><subject>Triacylglycerol</subject><subject>triacylglycerols</subject><subject>Triglycerides - analysis</subject><subject>Triglycerides - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU9v1DAQxS0EotvCiTtYSEUgFLDj-E-OUNGFagFB6dmaOM7GJYkX21HZL8FnxtWuWIQ4WeP5zdObeQg9ouQVJbJ-_fbiU0kIp0ypO2hBK8mLUojyLloQQmRBacWP0HGM17lUlNT30RHlteRUigX69dW2s7EthtZtfHRpi92EG5eSDXi0g5_w849-9KF1BrDpIcCUHLzAXZ4JkCJ2EUOM3jhI-evGpR4P_iZPJxfjbHEKbj1sjQ2utRimFvdu3ef2ZoA4Zsk8Zno_wOgmGx-gex0M0T7cvyfo6vzdt7P3xerz8sPZm1VhKkVT0YExbS3LpiGK1MCNYESqshENl50FU1ZKCMvbllUd7QxlZWMYWFYRYMwKxU7Qs53uJvgfs41Jjy4aOwwwWT9HLWQtBKUsg0__Aa_9HKbsTZf54oznq2fo5Q4ywccYbKc3wY0QtpoSfZuR_iujTD_eS87NaNsDuw8lA6d7AKKBocsnNy4eOFFXhFS33ood52KyP__0IXzP_pnkWiy_6KUi8nx1eaHrzD_Z8R14DeuQNa8uS0IZoYTWqlQHRQNjkwNb28O6_1vlNzHTwTw</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Chen, Qixuan</creator><creator>Li, Edmund T. S.</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines</title><author>Chen, Qixuan ; Li, Edmund T. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-faccd972bb0809a5c630782b6b57feac24866e5dd34f1fc132bc3ae340a33e683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>adipocytes</topic><topic>Adiposity</topic><topic>Animal Feed</topic><topic>animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bitter melon</topic><topic>Blood Glucose - analysis</topic><topic>Body weight</topic><topic>Catecholamines</topic><topic>Catecholamines - blood</topic><topic>cholesteremic effect</topic><topic>Cucurbitaceae</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Dose-response effects</topic><topic>Energy efficiency</topic><topic>experimental diets</topic><topic>Fatty acids</topic><topic>Fatty Liver - metabolism</topic><topic>Fatty Liver - pathology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>free fatty acids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glycemic effect</topic><topic>gourds</topic><topic>lipolysis</topic><topic>liver</topic><topic>Liver - chemistry</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>medicinal plants</topic><topic>Models, Animal</topic><topic>Momordica charantia</topic><topic>Muscle, Skeletal - chemistry</topic><topic>Obesity - metabolism</topic><topic>Obesity - pathology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>traditional medicine</topic><topic>Triacylglycerol</topic><topic>triacylglycerols</topic><topic>Triglycerides - analysis</topic><topic>Triglycerides - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Qixuan</creatorcontrib><creatorcontrib>Li, Edmund T. 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S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>93</volume><issue>5</issue><spage>747</spage><epage>754</epage><pages>747-754</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Slower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7·5 g/kg or 0·75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P<0·05) and steatosis score (P<0·05) similar to those in rats fed a low-fat diet. BM supplementation did not affect serum and hepatic cholesterol. However, plasma epinephrine and serum free fatty acid concentrations were increased (P<0·05). In the third experiment, BM(7·5 and 15 g/kg) and 1·5 % BM lowered triacylglycerol concentration in red gastrocnemius and tibialis anterior (P<0·05) muscle, but a dose–response effect was not observed. These data suggest that chronic BM feeding leads to a general decrease in tissue fat accumulation and that such an effect is mediated in part by enhanced sympathetic activity and lipolysis. BM or its bioactive ingredient(s) could be used as a dietary adjunct in the control of body weight and blood glucose.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>15975176</pmid><doi>10.1079/BJN20051388</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | adipocytes Adiposity Animal Feed animal models Animals Biological and medical sciences Bitter melon Blood Glucose - analysis Body weight Catecholamines Catecholamines - blood cholesteremic effect Cucurbitaceae Diet Dietary Supplements Dose-response effects Energy efficiency experimental diets Fatty acids Fatty Liver - metabolism Fatty Liver - pathology Feeding. Feeding behavior Female free fatty acids Fundamental and applied biological sciences. Psychology glycemic effect gourds lipolysis liver Liver - chemistry Liver - pathology Male medicinal plants Models, Animal Momordica charantia Muscle, Skeletal - chemistry Obesity - metabolism Obesity - pathology Random Allocation Rats Rats, Sprague-Dawley traditional medicine Triacylglycerol triacylglycerols Triglycerides - analysis Triglycerides - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
title | Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines |
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