Cortical changes to experimental sensitization of the human esophagus
Topographical organization in the neocortex shows experience-dependent plasticity. We hypothesized that experimental sensitization of the esophagus results in changes of the topographical distribution of the evoked potentials and the corresponding dipole source activities to painful stimulation. An...
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| Veröffentlicht in: | Neuroscience 2006-01, Vol.140 (1), p.269-279 |
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| creator | Sami, S.A.K. Rössel, P. Dimcevski, G. Nielsen, K. Dremstrup Funch-Jensen, P. Valeriani, M. Arendt-Nielsen, L. Drewes, A.M. |
| description | Topographical organization in the neocortex shows experience-dependent plasticity. We hypothesized that experimental sensitization of the esophagus results in changes of the topographical distribution of the evoked potentials and the corresponding dipole source activities to painful stimulation.
An endoscopic method was used to deliver 35 electrical stimuli at the pain threshold to a fixed area of the mucosa in 10 healthy volunteer men and women. The stimulations were repeated after 30 min (reproducibility experiment), and after 60 min following perfusion of 200 ml 0.1 N hydrochloric acid (sensitization experiment). During stimulation the electroencephalogram was recorded from 64 surface electrodes.
The sensitization resulted in a decrease in the pain threshold (
F=6.2;
P=0.004). The topographic distribution of the evoked potentials showed reproducible negative (N1, N2) and positive (P1, P2) components. After acid perfusion a reduced latency and a change in localization was seen for the P1 subdivided into frontal and occipital components (
F=29.5,
P |
| doi_str_mv | 10.1016/j.neuroscience.2006.02.031 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67965792</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0306452206002028</els_id><sourcerecordid>67965792</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-ade450c65fcb7a9a17c8cdd9376147c2980eabbabf89cd8776e57f3ff9e529403</originalsourceid><addsrcrecordid>eNqNkEtr3DAQgEVJaDZp_0IxhfRmR7IsyeotbPOChVzas5DlUVbLrrSV5JD011fpGtJbMpeB4ZvXh9BXghuCCb_YNB6mGJJx4A00Lca8wW2DKfmAFqQXtBas647QAlPM64617Qk6TWmDS7COfkQnhHNKKGELdLUMMTujt5VZa_8Aqcqhgqc9RLcDn0s9gU8uuz86u-CrYKu8hmo97bSvIIX9Wj9M6RM6tnqb4POcz9Cv66ufy9t6dX9zt7xc1YZhlms9Qsew4cyaQWipiTC9GUdJBSedMK3sMehh0IPtpRl7ITgwYam1ElgrO0zP0LfD3H0MvydIWe1cMrDdag9hSooLyZmQ7ZsgEYQzTGgBvx9AU4SmCFbty-c6PiuC1YtttVH_21YvthVuVbFdmr_MW6ZhB-Nr66y3AOczoFNxbKP2xqVXTggp5b9BPw4cFHmPDqKa140ugslqDO499_wFpcalwQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17165013</pqid></control><display><type>article</type><title>Cortical changes to experimental sensitization of the human esophagus</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Sami, S.A.K. ; Rössel, P. ; Dimcevski, G. ; Nielsen, K. Dremstrup ; Funch-Jensen, P. ; Valeriani, M. ; Arendt-Nielsen, L. ; Drewes, A.M.</creator><creatorcontrib>Sami, S.A.K. ; Rössel, P. ; Dimcevski, G. ; Nielsen, K. Dremstrup ; Funch-Jensen, P. ; Valeriani, M. ; Arendt-Nielsen, L. ; Drewes, A.M.</creatorcontrib><description>Topographical organization in the neocortex shows experience-dependent plasticity. We hypothesized that experimental sensitization of the esophagus results in changes of the topographical distribution of the evoked potentials and the corresponding dipole source activities to painful stimulation.
An endoscopic method was used to deliver 35 electrical stimuli at the pain threshold to a fixed area of the mucosa in 10 healthy volunteer men and women. The stimulations were repeated after 30 min (reproducibility experiment), and after 60 min following perfusion of 200 ml 0.1 N hydrochloric acid (sensitization experiment). During stimulation the electroencephalogram was recorded from 64 surface electrodes.
The sensitization resulted in a decrease in the pain threshold (
F=6.2;
P=0.004). The topographic distribution of the evoked potentials showed reproducible negative (N1, N2) and positive (P1, P2) components. After acid perfusion a reduced latency and a change in localization was seen for the P1 subdivided into frontal and occipital components (
F=29.5,
P<0.001;
F=53.7,
P<0.001). Furthermore the sensitization resulted in a reduction of the latency for P2 (
F=6.2,
P=0.009). The source analysis showed consistent dipolar activity in the bilateral opercular–insular cortex before and after acid perfusion. For the anterior cingulate dipole there was a reduction in latency (
P=0.03) and a posterior shift (
P=0.0002) following acid perfusion.
The findings indicate that short-term sensitization of the esophagus results in central neuroplastic changes involving the cingulate gyrus, which also showed pathological activation in functional diseases of the gut, thus reflecting the importance of this region in visceral pain and hyperalgesia.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2006.02.031</identifier><identifier>PMID: 16631315</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Biological and medical sciences ; Brain Mapping ; Cerebral Cortex - drug effects ; Cerebral Cortex - physiology ; Cerebral Cortex - radiation effects ; Electric Stimulation - methods ; Electroencephalography - methods ; Endoscopes ; esophagus ; Esophagus - drug effects ; Esophagus - innervation ; Esophagus - radiation effects ; Evoked Potentials, Somatosensory - physiology ; experimental pain ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hydrochloric Acid - administration & dosage ; Male ; Middle Aged ; Pain Measurement - methods ; Pain Threshold - drug effects ; Pain Threshold - radiation effects ; plasticity ; Reaction Time - drug effects ; Reaction Time - physiology ; Reaction Time - radiation effects ; Reproducibility of Results ; Sensitivity and Specificity ; sensitization ; Statistics, Nonparametric ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2006-01, Vol.140 (1), p.269-279</ispartof><rights>2006 IBRO</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-ade450c65fcb7a9a17c8cdd9376147c2980eabbabf89cd8776e57f3ff9e529403</citedby><cites>FETCH-LOGICAL-c505t-ade450c65fcb7a9a17c8cdd9376147c2980eabbabf89cd8776e57f3ff9e529403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452206002028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17799931$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16631315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sami, S.A.K.</creatorcontrib><creatorcontrib>Rössel, P.</creatorcontrib><creatorcontrib>Dimcevski, G.</creatorcontrib><creatorcontrib>Nielsen, K. Dremstrup</creatorcontrib><creatorcontrib>Funch-Jensen, P.</creatorcontrib><creatorcontrib>Valeriani, M.</creatorcontrib><creatorcontrib>Arendt-Nielsen, L.</creatorcontrib><creatorcontrib>Drewes, A.M.</creatorcontrib><title>Cortical changes to experimental sensitization of the human esophagus</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Topographical organization in the neocortex shows experience-dependent plasticity. We hypothesized that experimental sensitization of the esophagus results in changes of the topographical distribution of the evoked potentials and the corresponding dipole source activities to painful stimulation.
An endoscopic method was used to deliver 35 electrical stimuli at the pain threshold to a fixed area of the mucosa in 10 healthy volunteer men and women. The stimulations were repeated after 30 min (reproducibility experiment), and after 60 min following perfusion of 200 ml 0.1 N hydrochloric acid (sensitization experiment). During stimulation the electroencephalogram was recorded from 64 surface electrodes.
The sensitization resulted in a decrease in the pain threshold (
F=6.2;
P=0.004). The topographic distribution of the evoked potentials showed reproducible negative (N1, N2) and positive (P1, P2) components. After acid perfusion a reduced latency and a change in localization was seen for the P1 subdivided into frontal and occipital components (
F=29.5,
P<0.001;
F=53.7,
P<0.001). Furthermore the sensitization resulted in a reduction of the latency for P2 (
F=6.2,
P=0.009). The source analysis showed consistent dipolar activity in the bilateral opercular–insular cortex before and after acid perfusion. For the anterior cingulate dipole there was a reduction in latency (
P=0.03) and a posterior shift (
P=0.0002) following acid perfusion.
The findings indicate that short-term sensitization of the esophagus results in central neuroplastic changes involving the cingulate gyrus, which also showed pathological activation in functional diseases of the gut, thus reflecting the importance of this region in visceral pain and hyperalgesia.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - physiology</subject><subject>Cerebral Cortex - radiation effects</subject><subject>Electric Stimulation - methods</subject><subject>Electroencephalography - methods</subject><subject>Endoscopes</subject><subject>esophagus</subject><subject>Esophagus - drug effects</subject><subject>Esophagus - innervation</subject><subject>Esophagus - radiation effects</subject><subject>Evoked Potentials, Somatosensory - physiology</subject><subject>experimental pain</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hydrochloric Acid - administration & dosage</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pain Measurement - methods</subject><subject>Pain Threshold - drug effects</subject><subject>Pain Threshold - radiation effects</subject><subject>plasticity</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Reaction Time - radiation effects</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>sensitization</subject><subject>Statistics, Nonparametric</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtr3DAQgEVJaDZp_0IxhfRmR7IsyeotbPOChVzas5DlUVbLrrSV5JD011fpGtJbMpeB4ZvXh9BXghuCCb_YNB6mGJJx4A00Lca8wW2DKfmAFqQXtBas647QAlPM64617Qk6TWmDS7COfkQnhHNKKGELdLUMMTujt5VZa_8Aqcqhgqc9RLcDn0s9gU8uuz86u-CrYKu8hmo97bSvIIX9Wj9M6RM6tnqb4POcz9Cv66ufy9t6dX9zt7xc1YZhlms9Qsew4cyaQWipiTC9GUdJBSedMK3sMehh0IPtpRl7ITgwYam1ElgrO0zP0LfD3H0MvydIWe1cMrDdag9hSooLyZmQ7ZsgEYQzTGgBvx9AU4SmCFbty-c6PiuC1YtttVH_21YvthVuVbFdmr_MW6ZhB-Nr66y3AOczoFNxbKP2xqVXTggp5b9BPw4cFHmPDqKa140ugslqDO499_wFpcalwQ</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Sami, S.A.K.</creator><creator>Rössel, P.</creator><creator>Dimcevski, G.</creator><creator>Nielsen, K. Dremstrup</creator><creator>Funch-Jensen, P.</creator><creator>Valeriani, M.</creator><creator>Arendt-Nielsen, L.</creator><creator>Drewes, A.M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Cortical changes to experimental sensitization of the human esophagus</title><author>Sami, S.A.K. ; Rössel, P. ; Dimcevski, G. ; Nielsen, K. Dremstrup ; Funch-Jensen, P. ; Valeriani, M. ; Arendt-Nielsen, L. ; Drewes, A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-ade450c65fcb7a9a17c8cdd9376147c2980eabbabf89cd8776e57f3ff9e529403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - physiology</topic><topic>Cerebral Cortex - radiation effects</topic><topic>Electric Stimulation - methods</topic><topic>Electroencephalography - methods</topic><topic>Endoscopes</topic><topic>esophagus</topic><topic>Esophagus - drug effects</topic><topic>Esophagus - innervation</topic><topic>Esophagus - radiation effects</topic><topic>Evoked Potentials, Somatosensory - physiology</topic><topic>experimental pain</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hydrochloric Acid - administration & dosage</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pain Measurement - methods</topic><topic>Pain Threshold - drug effects</topic><topic>Pain Threshold - radiation effects</topic><topic>plasticity</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Reaction Time - radiation effects</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>sensitization</topic><topic>Statistics, Nonparametric</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sami, S.A.K.</creatorcontrib><creatorcontrib>Rössel, P.</creatorcontrib><creatorcontrib>Dimcevski, G.</creatorcontrib><creatorcontrib>Nielsen, K. Dremstrup</creatorcontrib><creatorcontrib>Funch-Jensen, P.</creatorcontrib><creatorcontrib>Valeriani, M.</creatorcontrib><creatorcontrib>Arendt-Nielsen, L.</creatorcontrib><creatorcontrib>Drewes, A.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sami, S.A.K.</au><au>Rössel, P.</au><au>Dimcevski, G.</au><au>Nielsen, K. Dremstrup</au><au>Funch-Jensen, P.</au><au>Valeriani, M.</au><au>Arendt-Nielsen, L.</au><au>Drewes, A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical changes to experimental sensitization of the human esophagus</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>140</volume><issue>1</issue><spage>269</spage><epage>279</epage><pages>269-279</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Topographical organization in the neocortex shows experience-dependent plasticity. We hypothesized that experimental sensitization of the esophagus results in changes of the topographical distribution of the evoked potentials and the corresponding dipole source activities to painful stimulation.
An endoscopic method was used to deliver 35 electrical stimuli at the pain threshold to a fixed area of the mucosa in 10 healthy volunteer men and women. The stimulations were repeated after 30 min (reproducibility experiment), and after 60 min following perfusion of 200 ml 0.1 N hydrochloric acid (sensitization experiment). During stimulation the electroencephalogram was recorded from 64 surface electrodes.
The sensitization resulted in a decrease in the pain threshold (
F=6.2;
P=0.004). The topographic distribution of the evoked potentials showed reproducible negative (N1, N2) and positive (P1, P2) components. After acid perfusion a reduced latency and a change in localization was seen for the P1 subdivided into frontal and occipital components (
F=29.5,
P<0.001;
F=53.7,
P<0.001). Furthermore the sensitization resulted in a reduction of the latency for P2 (
F=6.2,
P=0.009). The source analysis showed consistent dipolar activity in the bilateral opercular–insular cortex before and after acid perfusion. For the anterior cingulate dipole there was a reduction in latency (
P=0.03) and a posterior shift (
P=0.0002) following acid perfusion.
The findings indicate that short-term sensitization of the esophagus results in central neuroplastic changes involving the cingulate gyrus, which also showed pathological activation in functional diseases of the gut, thus reflecting the importance of this region in visceral pain and hyperalgesia.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16631315</pmid><doi>10.1016/j.neuroscience.2006.02.031</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Brain Mapping Cerebral Cortex - drug effects Cerebral Cortex - physiology Cerebral Cortex - radiation effects Electric Stimulation - methods Electroencephalography - methods Endoscopes esophagus Esophagus - drug effects Esophagus - innervation Esophagus - radiation effects Evoked Potentials, Somatosensory - physiology experimental pain Female Fundamental and applied biological sciences. Psychology Humans Hydrochloric Acid - administration & dosage Male Middle Aged Pain Measurement - methods Pain Threshold - drug effects Pain Threshold - radiation effects plasticity Reaction Time - drug effects Reaction Time - physiology Reaction Time - radiation effects Reproducibility of Results Sensitivity and Specificity sensitization Statistics, Nonparametric Vertebrates: nervous system and sense organs |
| title | Cortical changes to experimental sensitization of the human esophagus |
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