Sex Hormone-binding Globulin (SHBG) and Estradiol Cross-talk in Breast Cancer Cells
Abstract Sex Hormone-binding Globulin (SHBG) is a plasma glycoprotein that regulates the action of steroid hormones at several levels. SHBG regulates the availability of free androgens and estradiol to hormone-responsive tissues. Moreover, SHBG is also part of a novel steroid signaling system. We re...
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| Veröffentlicht in: | Hormone and metabolic research 2006-04, Vol.38 (4), p.236-240 |
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| container_title | Hormone and metabolic research |
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| creator | Fortunati, N. Catalano, M. G. |
| description | Abstract
Sex Hormone-binding Globulin (SHBG) is a plasma glycoprotein that regulates the action of steroid hormones at several levels. SHBG regulates the availability of free androgens and estradiol to hormone-responsive tissues. Moreover, SHBG is also part of a novel steroid signaling system. We report here on the mechanism of action and the biological effects of SHBG in breast cancer cells, especially distinguishing cross-talk between membrane-initiated SHBG and estradiol pathways. After interacting with a specific binding site on breast cancer cell membranes, SHBG activates a specific pathway, and by cAMP induction, inhibits estradiol-mediated activation of ERK. Both estradiol and SHBG membrane-initiated pathways involve cross-talk at MAP kinase level with the ultimate result of inhibiting estradiol-mediated cell growth and antiapoptosis. On the basis of reported evidence, we suggest that SHBG is one of the regulators of growth and apoptosis of estrogen-dependent breast cancer cells. |
| doi_str_mv | 10.1055/s-2006-925337 |
| format | Article |
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Sex Hormone-binding Globulin (SHBG) is a plasma glycoprotein that regulates the action of steroid hormones at several levels. SHBG regulates the availability of free androgens and estradiol to hormone-responsive tissues. Moreover, SHBG is also part of a novel steroid signaling system. We report here on the mechanism of action and the biological effects of SHBG in breast cancer cells, especially distinguishing cross-talk between membrane-initiated SHBG and estradiol pathways. After interacting with a specific binding site on breast cancer cell membranes, SHBG activates a specific pathway, and by cAMP induction, inhibits estradiol-mediated activation of ERK. Both estradiol and SHBG membrane-initiated pathways involve cross-talk at MAP kinase level with the ultimate result of inhibiting estradiol-mediated cell growth and antiapoptosis. On the basis of reported evidence, we suggest that SHBG is one of the regulators of growth and apoptosis of estrogen-dependent breast cancer cells.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2006-925337</identifier><identifier>PMID: 16700004</identifier><language>eng</language><publisher>Germany</publisher><subject>Breast Neoplasms - metabolism ; Cell Line, Tumor ; Cell Membrane - metabolism ; Estradiol - metabolism ; Humans ; Membrane Proteins - metabolism ; Receptor Cross-Talk - physiology ; Review ; Sex Hormone-Binding Globulin - metabolism ; Signal Transduction</subject><ispartof>Hormone and metabolic research, 2006-04, Vol.38 (4), p.236-240</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-ec34500f18a7a4f9a6a26e9a675aed89fd137bc4be16114a75c8fde257f04f503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-925337.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2006-925337$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3015,3016,27923,27924,54558,54559</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16700004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fortunati, N.</creatorcontrib><creatorcontrib>Catalano, M. G.</creatorcontrib><title>Sex Hormone-binding Globulin (SHBG) and Estradiol Cross-talk in Breast Cancer Cells</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Abstract
Sex Hormone-binding Globulin (SHBG) is a plasma glycoprotein that regulates the action of steroid hormones at several levels. SHBG regulates the availability of free androgens and estradiol to hormone-responsive tissues. Moreover, SHBG is also part of a novel steroid signaling system. We report here on the mechanism of action and the biological effects of SHBG in breast cancer cells, especially distinguishing cross-talk between membrane-initiated SHBG and estradiol pathways. After interacting with a specific binding site on breast cancer cell membranes, SHBG activates a specific pathway, and by cAMP induction, inhibits estradiol-mediated activation of ERK. Both estradiol and SHBG membrane-initiated pathways involve cross-talk at MAP kinase level with the ultimate result of inhibiting estradiol-mediated cell growth and antiapoptosis. On the basis of reported evidence, we suggest that SHBG is one of the regulators of growth and apoptosis of estrogen-dependent breast cancer cells.</description><subject>Breast Neoplasms - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Membrane - metabolism</subject><subject>Estradiol - metabolism</subject><subject>Humans</subject><subject>Membrane Proteins - metabolism</subject><subject>Receptor Cross-Talk - physiology</subject><subject>Review</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>Signal Transduction</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1Lw0AQhhdRbK0evcqeRMHV3exXcrShtkLBQ_W8bJKJpuaj7iag_94tKXhyLi8DDy8zD0KXjN4zKuWDJxGliiSR5FwfoSkTPCEiitUxmlLKYiKp4BN05v02rCJh4hRNmNI0jJiizQa-8apzTdcCyaq2qNp3vKy7bKirFt9sVvPlLbZtgRe-d7aouhqnrvOe9Lb-xAGZO7C-x6ltc3A4hbr25-iktLWHi0PO0NvT4jVdkfXL8jl9XJOcK90TyLmQlJYsttqKMrHKRgpCaGmhiJOyYFxnuciAKcaE1TKPywIiqUsqSkn5DF2PvTvXfQ3ge9NUPg8X2Ba6wRulEyV5nASQjGC-P91BaXauaqz7MYyavUXjzd6iGS0G_upQPGQNFH_0QVsA7kag_6igAbPtBteGV__p-wVh1nln</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Fortunati, N.</creator><creator>Catalano, M. G.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Sex Hormone-binding Globulin (SHBG) and Estradiol Cross-talk in Breast Cancer Cells</title><author>Fortunati, N. ; Catalano, M. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-ec34500f18a7a4f9a6a26e9a675aed89fd137bc4be16114a75c8fde257f04f503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Breast Neoplasms - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Membrane - metabolism</topic><topic>Estradiol - metabolism</topic><topic>Humans</topic><topic>Membrane Proteins - metabolism</topic><topic>Receptor Cross-Talk - physiology</topic><topic>Review</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fortunati, N.</creatorcontrib><creatorcontrib>Catalano, M. G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fortunati, N.</au><au>Catalano, M. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex Hormone-binding Globulin (SHBG) and Estradiol Cross-talk in Breast Cancer Cells</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>2006-04</date><risdate>2006</risdate><volume>38</volume><issue>4</issue><spage>236</spage><epage>240</epage><pages>236-240</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><abstract>Abstract
Sex Hormone-binding Globulin (SHBG) is a plasma glycoprotein that regulates the action of steroid hormones at several levels. SHBG regulates the availability of free androgens and estradiol to hormone-responsive tissues. Moreover, SHBG is also part of a novel steroid signaling system. We report here on the mechanism of action and the biological effects of SHBG in breast cancer cells, especially distinguishing cross-talk between membrane-initiated SHBG and estradiol pathways. After interacting with a specific binding site on breast cancer cell membranes, SHBG activates a specific pathway, and by cAMP induction, inhibits estradiol-mediated activation of ERK. Both estradiol and SHBG membrane-initiated pathways involve cross-talk at MAP kinase level with the ultimate result of inhibiting estradiol-mediated cell growth and antiapoptosis. On the basis of reported evidence, we suggest that SHBG is one of the regulators of growth and apoptosis of estrogen-dependent breast cancer cells.</abstract><cop>Germany</cop><pmid>16700004</pmid><doi>10.1055/s-2006-925337</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Hormone and metabolic research, 2006-04, Vol.38 (4), p.236-240 |
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| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Breast Neoplasms - metabolism Cell Line, Tumor Cell Membrane - metabolism Estradiol - metabolism Humans Membrane Proteins - metabolism Receptor Cross-Talk - physiology Review Sex Hormone-Binding Globulin - metabolism Signal Transduction |
| title | Sex Hormone-binding Globulin (SHBG) and Estradiol Cross-talk in Breast Cancer Cells |
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