Prevalence of HLA antibodies in transfused patients with and without red cell antibodies
BACKGROUND: Multiply transfused patients are at increased risk of developing red cell (RBC) antibodies, as well as antibodies to HLA. Although pretransfusion testing screens for RBC antibodies, no such testing is routinely performed for HLA antibodies. Determining which patients are more likely to...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2006-05, Vol.46 (5), p.754-756 |
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| container_title | Transfusion (Philadelphia, Pa.) |
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| creator | Buetens, Orin Shirey, R. Sue Goble-Lee, Mary Houp, Julie Zachary, Andrea King, Karen E. Ness, Paul M. |
| description | BACKGROUND: Multiply transfused patients are at increased risk of developing red cell (RBC) antibodies, as well as antibodies to HLA. Although pretransfusion testing screens for RBC antibodies, no such testing is routinely performed for HLA antibodies. Determining which patients are more likely to make HLA antibodies may be important for patients undergoing elective surgery where platelets (PLTs) may be required. It is hypothesized that patients with RBC alloantibodies may be more likely to have HLA antibodies than previously transfused patients without RBC antibodies.
STUDY DESIGN AND METHODS: Blood was collected from 53 adult male surgical patients with RBC alloantibodies and a control group of 69 similar male patients with a history of previous transfusions but no evidence of RBC alloimmunization. The samples were tested for the presence of immunoglobulin G Class I HLA antibodies by enzyme‐linked immunosorbent assay.
RESULTS: Of the 53 samples from patients with RBC alloantibodies, 12 (22.6%) also had HLA antibodies, whereas only 7 (10.1%) of the 69 patients in the control group had HLA antibodies (p |
| doi_str_mv | 10.1111/j.1537-2995.2006.00793.x |
| format | Article |
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STUDY DESIGN AND METHODS: Blood was collected from 53 adult male surgical patients with RBC alloantibodies and a control group of 69 similar male patients with a history of previous transfusions but no evidence of RBC alloimmunization. The samples were tested for the presence of immunoglobulin G Class I HLA antibodies by enzyme‐linked immunosorbent assay.
RESULTS: Of the 53 samples from patients with RBC alloantibodies, 12 (22.6%) also had HLA antibodies, whereas only 7 (10.1%) of the 69 patients in the control group had HLA antibodies (p < 0.03).
CONCLUSIONS: There is a significant difference between the rates of HLA alloimmunization in male patients with RBC antibodies versus multiply transfused patients without RBC antibodies. Screening for HLA antibodies may be warranted in patients with RBC alloantibodies who might require PLT transfusion support for elective surgery.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2006.00793.x</identifier><identifier>PMID: 16686842</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Loss, Surgical - prevention & control ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Elective Surgical Procedures ; Erythrocyte Transfusion - adverse effects ; Erythrocytes - immunology ; Hematology ; Histocompatibility Antigens Class I - blood ; Histocompatibility Antigens Class I - immunology ; HLA Antigens - blood ; HLA Antigens - immunology ; Humans ; Immunoglobulin G - blood ; Immunoglobulin G - immunology ; Investigative techniques, diagnostic techniques (general aspects) ; Isoantibodies - blood ; Isoantibodies - immunology ; Male ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Platelet Transfusion ; Prevalence ; Risk Factors ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Transfusion (Philadelphia, Pa.), 2006-05, Vol.46 (5), p.754-756</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4363-bf740ec8df3b1be5c177e517ef8c510ad0088b2406bb98635967c57d26c46cc23</citedby><cites>FETCH-LOGICAL-c4363-bf740ec8df3b1be5c177e517ef8c510ad0088b2406bb98635967c57d26c46cc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2006.00793.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2006.00793.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17771589$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16686842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buetens, Orin</creatorcontrib><creatorcontrib>Shirey, R. Sue</creatorcontrib><creatorcontrib>Goble-Lee, Mary</creatorcontrib><creatorcontrib>Houp, Julie</creatorcontrib><creatorcontrib>Zachary, Andrea</creatorcontrib><creatorcontrib>King, Karen E.</creatorcontrib><creatorcontrib>Ness, Paul M.</creatorcontrib><title>Prevalence of HLA antibodies in transfused patients with and without red cell antibodies</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Multiply transfused patients are at increased risk of developing red cell (RBC) antibodies, as well as antibodies to HLA. Although pretransfusion testing screens for RBC antibodies, no such testing is routinely performed for HLA antibodies. Determining which patients are more likely to make HLA antibodies may be important for patients undergoing elective surgery where platelets (PLTs) may be required. It is hypothesized that patients with RBC alloantibodies may be more likely to have HLA antibodies than previously transfused patients without RBC antibodies.
STUDY DESIGN AND METHODS: Blood was collected from 53 adult male surgical patients with RBC alloantibodies and a control group of 69 similar male patients with a history of previous transfusions but no evidence of RBC alloimmunization. The samples were tested for the presence of immunoglobulin G Class I HLA antibodies by enzyme‐linked immunosorbent assay.
RESULTS: Of the 53 samples from patients with RBC alloantibodies, 12 (22.6%) also had HLA antibodies, whereas only 7 (10.1%) of the 69 patients in the control group had HLA antibodies (p < 0.03).
CONCLUSIONS: There is a significant difference between the rates of HLA alloimmunization in male patients with RBC antibodies versus multiply transfused patients without RBC antibodies. Screening for HLA antibodies may be warranted in patients with RBC alloantibodies who might require PLT transfusion support for elective surgery.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Loss, Surgical - prevention & control</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Elective Surgical Procedures</subject><subject>Erythrocyte Transfusion - adverse effects</subject><subject>Erythrocytes - immunology</subject><subject>Hematology</subject><subject>Histocompatibility Antigens Class I - blood</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>HLA Antigens - blood</subject><subject>HLA Antigens - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Isoantibodies - blood</subject><subject>Isoantibodies - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Platelet Transfusion</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyBf4JZ0HMcfuSBVVT-oVoBWReVmOc5EeMkmi53Q7b_H2V21HPHFI80zr8cPIZRBztI5W-dMcJUVVSXyAkDmAKri-e4FWTw1XpIFQMkyxnhxQt7EuAaAogL2mpwwKbXUZbEgP74F_GM77B3SoaU3y3Nq-9HXQ-MxUt_TMdg-tlPEhm7t6LEfI33w48-ENftimEYaUtdh1_0z-5a8am0X8d3xPiXfry7vLm6y5dfrzxfny8yVXPKsblUJ6HTT8prVKBxTCgVT2GonGNgGQOu6KEHWdaUlF5VUTqimkK6UzhX8lHw85G7D8HvCOJqNj_MutsdhikaqSpZcQwL1AXRhiDFga7bBb2x4NAzMbNWszSzPzPLMbNXsrZpdGn1_fGOqN9g8Dx41JuDDEbDR2a5NzpyPz5xSigldJe7TgXvwHT7-9wLmbnW1L1NAdgjwccTdU4ANv9JHuRLm_su10eJer1ayNLf8L01pojw</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Buetens, Orin</creator><creator>Shirey, R. Sue</creator><creator>Goble-Lee, Mary</creator><creator>Houp, Julie</creator><creator>Zachary, Andrea</creator><creator>King, Karen E.</creator><creator>Ness, Paul M.</creator><general>Blackwell Publishing Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Prevalence of HLA antibodies in transfused patients with and without red cell antibodies</title><author>Buetens, Orin ; Shirey, R. Sue ; Goble-Lee, Mary ; Houp, Julie ; Zachary, Andrea ; King, Karen E. ; Ness, Paul M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4363-bf740ec8df3b1be5c177e517ef8c510ad0088b2406bb98635967c57d26c46cc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Loss, Surgical - prevention & control</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Elective Surgical Procedures</topic><topic>Erythrocyte Transfusion - adverse effects</topic><topic>Erythrocytes - immunology</topic><topic>Hematology</topic><topic>Histocompatibility Antigens Class I - blood</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>HLA Antigens - blood</topic><topic>HLA Antigens - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - immunology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Isoantibodies - blood</topic><topic>Isoantibodies - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Platelet Transfusion</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buetens, Orin</creatorcontrib><creatorcontrib>Shirey, R. Sue</creatorcontrib><creatorcontrib>Goble-Lee, Mary</creatorcontrib><creatorcontrib>Houp, Julie</creatorcontrib><creatorcontrib>Zachary, Andrea</creatorcontrib><creatorcontrib>King, Karen E.</creatorcontrib><creatorcontrib>Ness, Paul M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buetens, Orin</au><au>Shirey, R. Sue</au><au>Goble-Lee, Mary</au><au>Houp, Julie</au><au>Zachary, Andrea</au><au>King, Karen E.</au><au>Ness, Paul M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of HLA antibodies in transfused patients with and without red cell antibodies</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2006-05</date><risdate>2006</risdate><volume>46</volume><issue>5</issue><spage>754</spage><epage>756</epage><pages>754-756</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Multiply transfused patients are at increased risk of developing red cell (RBC) antibodies, as well as antibodies to HLA. Although pretransfusion testing screens for RBC antibodies, no such testing is routinely performed for HLA antibodies. Determining which patients are more likely to make HLA antibodies may be important for patients undergoing elective surgery where platelets (PLTs) may be required. It is hypothesized that patients with RBC alloantibodies may be more likely to have HLA antibodies than previously transfused patients without RBC antibodies.
STUDY DESIGN AND METHODS: Blood was collected from 53 adult male surgical patients with RBC alloantibodies and a control group of 69 similar male patients with a history of previous transfusions but no evidence of RBC alloimmunization. The samples were tested for the presence of immunoglobulin G Class I HLA antibodies by enzyme‐linked immunosorbent assay.
RESULTS: Of the 53 samples from patients with RBC alloantibodies, 12 (22.6%) also had HLA antibodies, whereas only 7 (10.1%) of the 69 patients in the control group had HLA antibodies (p < 0.03).
CONCLUSIONS: There is a significant difference between the rates of HLA alloimmunization in male patients with RBC antibodies versus multiply transfused patients without RBC antibodies. Screening for HLA antibodies may be warranted in patients with RBC alloantibodies who might require PLT transfusion support for elective surgery.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>16686842</pmid><doi>10.1111/j.1537-2995.2006.00793.x</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Loss, Surgical - prevention & control Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction Elective Surgical Procedures Erythrocyte Transfusion - adverse effects Erythrocytes - immunology Hematology Histocompatibility Antigens Class I - blood Histocompatibility Antigens Class I - immunology HLA Antigens - blood HLA Antigens - immunology Humans Immunoglobulin G - blood Immunoglobulin G - immunology Investigative techniques, diagnostic techniques (general aspects) Isoantibodies - blood Isoantibodies - immunology Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Platelet Transfusion Prevalence Risk Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Prevalence of HLA antibodies in transfused patients with and without red cell antibodies |
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