Protection of mouse small bowel allografts by FTY720 and costimulation blockade

The clinical application of small bowel transplantation (SBTx) is hampered by its pronounced immunogenicity. We aimed to test the hypothesis that prolonged sequestration of lymphocytes in secondary lymphoid organs may enhance the alloprotective effect of costimulation blockade. For this purpose, rec...

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Veröffentlicht in:	Transplantation 2005-06, Vol.79 (12), p.1703-1710
Hauptverfasser:	SHENG YAN, RODRIGUEZ-BARBOSA, Jose-Ignacio, PABST, Oliver, BECKMANN, Jan H, BRINKMANN, Volker, FÖRSTER, Reinhold, HOFFMANN, Matthias W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Biological and medical sciences Fingolimod Hydrochloride Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - immunology Graft Survival - drug effects Graft Survival - immunology Immunosuppressive Agents - therapeutic use Intestine, Small - drug effects Intestine, Small - transplantation Lymphocytes - drug effects Lymphocytes - immunology Medical sciences Mice Mice, Inbred C3H Mice, Inbred C57BL Propylene Glycols - therapeutic use Sphingosine - analogs & derivatives Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Transplantation, Homologous - immunology
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