Lipid droplets are present in amyloid deposits in familial amyloidotic polyneuropathy and dialysis related amyloidosis
It has been well documented that transthyretin (TTR) shows an affinity for lipoproteins and amyloid is deposited around adipocytes in patients with familial amyloidotic polyneuropathy (FAP). We examined the involvement of lipids in amyloid fibrils in the tissues by histopathologic methods. Sudan bla...
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| Veröffentlicht in: | Amyloid 2006-03, Vol.13 (1), p.20-23 |
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| creator | Sun, Xuguo Ueda, Mitsuharu Yamashita, Taro Nakamura, Masaaki Bergström, Joakim Zeledon Ramirez, Manuel E. Okajima, Miyo Misumi, Shogo Shoji, Shozo Motomiya, Yoshihiro Ando, Yukio |
| description | It has been well documented that transthyretin (TTR) shows an affinity for lipoproteins and amyloid is deposited around adipocytes in patients with familial amyloidotic polyneuropathy (FAP). We examined the involvement of lipids in amyloid fibrils in the tissues by histopathologic methods. Sudan black B staining for frozen tissues of autopsied FAP patients and biospied dialysis related amyloidosis (DRA) patients revealed colocalization of lipids in the tissue sections where Congo red staining was positive, while no such positive staining was observed in paraffin embedded tissues. Immunohistochemical study using lipoprotein antibodies revealed that only anti-high density lipoprotein (HDL) antibody showed immunoreactivity in both types of amyloid specimens where Congo red was positively stained. Measurement of the components of lipids in the frozen cardiac samples from an FAP patient and an amyotrophic lateral sclerosis (ALS) patient revealed that concentrations of triglyceride and cholesterol in each lipoprotein, except for HDL-triglyceride, were markedly elevated in the FAP patient's material, compared to that of the ALS patient. These results suggest that interaction of amyloid fibrils with HDL may play an important role in amyloid formation in FAP. |
| doi_str_mv | 10.1080/13506120500537137 |
| format | Article |
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We examined the involvement of lipids in amyloid fibrils in the tissues by histopathologic methods. Sudan black B staining for frozen tissues of autopsied FAP patients and biospied dialysis related amyloidosis (DRA) patients revealed colocalization of lipids in the tissue sections where Congo red staining was positive, while no such positive staining was observed in paraffin embedded tissues. Immunohistochemical study using lipoprotein antibodies revealed that only anti-high density lipoprotein (HDL) antibody showed immunoreactivity in both types of amyloid specimens where Congo red was positively stained. Measurement of the components of lipids in the frozen cardiac samples from an FAP patient and an amyotrophic lateral sclerosis (ALS) patient revealed that concentrations of triglyceride and cholesterol in each lipoprotein, except for HDL-triglyceride, were markedly elevated in the FAP patient's material, compared to that of the ALS patient. These results suggest that interaction of amyloid fibrils with HDL may play an important role in amyloid formation in FAP.</description><identifier>ISSN: 1350-6129</identifier><identifier>EISSN: 1744-2818</identifier><identifier>DOI: 10.1080/13506120500537137</identifier><identifier>PMID: 16690496</identifier><identifier>CODEN: AIJIET</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; amyloid ; Amyloid - chemistry ; Amyloid - metabolism ; Amyloid - physiology ; Amyloid Neuropathies, Familial - metabolism ; Amyloid Neuropathies, Familial - pathology ; Cholesterol, HDL - metabolism ; dialysis ; familial amyloidotic polyneuropathy ; Female ; HDL ; Humans ; Lipid Metabolism - physiology ; Lipids ; Male ; Middle Aged ; related amyloidosis ; Renal Dialysis - adverse effects ; Triglycerides - metabolism</subject><ispartof>Amyloid, 2006-03, Vol.13 (1), p.20-23</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><rights>Copyright Taylor & Francis Ltd. Mar 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-27e74141c23bcb61f9e62afbf4dd57720910054e0925dc9eeeb64d7ff09255123</citedby><cites>FETCH-LOGICAL-c462t-27e74141c23bcb61f9e62afbf4dd57720910054e0925dc9eeeb64d7ff09255123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13506120500537137$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13506120500537137$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16690496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Xuguo</creatorcontrib><creatorcontrib>Ueda, Mitsuharu</creatorcontrib><creatorcontrib>Yamashita, Taro</creatorcontrib><creatorcontrib>Nakamura, Masaaki</creatorcontrib><creatorcontrib>Bergström, Joakim</creatorcontrib><creatorcontrib>Zeledon Ramirez, Manuel E.</creatorcontrib><creatorcontrib>Okajima, Miyo</creatorcontrib><creatorcontrib>Misumi, Shogo</creatorcontrib><creatorcontrib>Shoji, Shozo</creatorcontrib><creatorcontrib>Motomiya, Yoshihiro</creatorcontrib><creatorcontrib>Ando, Yukio</creatorcontrib><title>Lipid droplets are present in amyloid deposits in familial amyloidotic polyneuropathy and dialysis related amyloidosis</title><title>Amyloid</title><addtitle>Amyloid</addtitle><description>It has been well documented that transthyretin (TTR) shows an affinity for lipoproteins and amyloid is deposited around adipocytes in patients with familial amyloidotic polyneuropathy (FAP). We examined the involvement of lipids in amyloid fibrils in the tissues by histopathologic methods. Sudan black B staining for frozen tissues of autopsied FAP patients and biospied dialysis related amyloidosis (DRA) patients revealed colocalization of lipids in the tissue sections where Congo red staining was positive, while no such positive staining was observed in paraffin embedded tissues. Immunohistochemical study using lipoprotein antibodies revealed that only anti-high density lipoprotein (HDL) antibody showed immunoreactivity in both types of amyloid specimens where Congo red was positively stained. Measurement of the components of lipids in the frozen cardiac samples from an FAP patient and an amyotrophic lateral sclerosis (ALS) patient revealed that concentrations of triglyceride and cholesterol in each lipoprotein, except for HDL-triglyceride, were markedly elevated in the FAP patient's material, compared to that of the ALS patient. These results suggest that interaction of amyloid fibrils with HDL may play an important role in amyloid formation in FAP.</description><subject>Adult</subject><subject>amyloid</subject><subject>Amyloid - chemistry</subject><subject>Amyloid - metabolism</subject><subject>Amyloid - physiology</subject><subject>Amyloid Neuropathies, Familial - metabolism</subject><subject>Amyloid Neuropathies, Familial - pathology</subject><subject>Cholesterol, HDL - metabolism</subject><subject>dialysis</subject><subject>familial amyloidotic polyneuropathy</subject><subject>Female</subject><subject>HDL</subject><subject>Humans</subject><subject>Lipid Metabolism - physiology</subject><subject>Lipids</subject><subject>Male</subject><subject>Middle Aged</subject><subject>related amyloidosis</subject><subject>Renal Dialysis - adverse effects</subject><subject>Triglycerides - metabolism</subject><issn>1350-6129</issn><issn>1744-2818</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkUuLFDEUhYM4OOPoD3AjhYvZlZNXJRV0I4MvaHCj65Cq3NAZUpUySSn17ydNt2_UVcI93zlw70HoCcHPCe7xNWEdFoTiDuOOScLkPXRBJOct7Ul_v_6r3lZAnaOHOd9iTBlW_QN0ToRQmCtxgb7s_OJtY1NcApTcmATNkiDDXBo_N2baQjzosMTsq15nzkw-eBO-ibH4sVli2GZYa4wp-60xc_VUZss-NwmCKWC_83X2CJ05EzI8Pr2X6NOb1x9v3rW7D2_f37zatSMXtLRUguSEk5GyYRwEcQoENW5w3NpOSooVqatzwIp2dlQAMAhupXOHQUcou0RXx9wlxc8r5KInn0cIwcwQ16yFVIIR0v8XpJj2jFNRwWe_gbdxTXNdQhPV90xxySpEjtCYYs4JnF6Sn0zaNMH6UJ3-o7rqeXoKXocJ7A_HqasKvDwCfnYxTeZrTMHqYupRk0tmHn3W7F_5L36x78GEsh9r4T9t8Ff3HbbyuoU</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Sun, Xuguo</creator><creator>Ueda, Mitsuharu</creator><creator>Yamashita, Taro</creator><creator>Nakamura, Masaaki</creator><creator>Bergström, Joakim</creator><creator>Zeledon Ramirez, Manuel E.</creator><creator>Okajima, Miyo</creator><creator>Misumi, Shogo</creator><creator>Shoji, Shozo</creator><creator>Motomiya, Yoshihiro</creator><creator>Ando, Yukio</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Lipid droplets are present in amyloid deposits in familial amyloidotic polyneuropathy and dialysis related amyloidosis</title><author>Sun, Xuguo ; Ueda, Mitsuharu ; Yamashita, Taro ; Nakamura, Masaaki ; Bergström, Joakim ; Zeledon Ramirez, Manuel E. ; Okajima, Miyo ; Misumi, Shogo ; Shoji, Shozo ; Motomiya, Yoshihiro ; Ando, Yukio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-27e74141c23bcb61f9e62afbf4dd57720910054e0925dc9eeeb64d7ff09255123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>amyloid</topic><topic>Amyloid - chemistry</topic><topic>Amyloid - metabolism</topic><topic>Amyloid - physiology</topic><topic>Amyloid Neuropathies, Familial - metabolism</topic><topic>Amyloid Neuropathies, Familial - pathology</topic><topic>Cholesterol, HDL - metabolism</topic><topic>dialysis</topic><topic>familial amyloidotic polyneuropathy</topic><topic>Female</topic><topic>HDL</topic><topic>Humans</topic><topic>Lipid Metabolism - physiology</topic><topic>Lipids</topic><topic>Male</topic><topic>Middle Aged</topic><topic>related amyloidosis</topic><topic>Renal Dialysis - adverse effects</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Xuguo</creatorcontrib><creatorcontrib>Ueda, Mitsuharu</creatorcontrib><creatorcontrib>Yamashita, Taro</creatorcontrib><creatorcontrib>Nakamura, Masaaki</creatorcontrib><creatorcontrib>Bergström, Joakim</creatorcontrib><creatorcontrib>Zeledon Ramirez, Manuel E.</creatorcontrib><creatorcontrib>Okajima, Miyo</creatorcontrib><creatorcontrib>Misumi, Shogo</creatorcontrib><creatorcontrib>Shoji, Shozo</creatorcontrib><creatorcontrib>Motomiya, Yoshihiro</creatorcontrib><creatorcontrib>Ando, Yukio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Amyloid</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Xuguo</au><au>Ueda, Mitsuharu</au><au>Yamashita, Taro</au><au>Nakamura, Masaaki</au><au>Bergström, Joakim</au><au>Zeledon Ramirez, Manuel E.</au><au>Okajima, Miyo</au><au>Misumi, Shogo</au><au>Shoji, Shozo</au><au>Motomiya, Yoshihiro</au><au>Ando, Yukio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid droplets are present in amyloid deposits in familial amyloidotic polyneuropathy and dialysis related amyloidosis</atitle><jtitle>Amyloid</jtitle><addtitle>Amyloid</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>13</volume><issue>1</issue><spage>20</spage><epage>23</epage><pages>20-23</pages><issn>1350-6129</issn><eissn>1744-2818</eissn><coden>AIJIET</coden><abstract>It has been well documented that transthyretin (TTR) shows an affinity for lipoproteins and amyloid is deposited around adipocytes in patients with familial amyloidotic polyneuropathy (FAP). We examined the involvement of lipids in amyloid fibrils in the tissues by histopathologic methods. Sudan black B staining for frozen tissues of autopsied FAP patients and biospied dialysis related amyloidosis (DRA) patients revealed colocalization of lipids in the tissue sections where Congo red staining was positive, while no such positive staining was observed in paraffin embedded tissues. Immunohistochemical study using lipoprotein antibodies revealed that only anti-high density lipoprotein (HDL) antibody showed immunoreactivity in both types of amyloid specimens where Congo red was positively stained. Measurement of the components of lipids in the frozen cardiac samples from an FAP patient and an amyotrophic lateral sclerosis (ALS) patient revealed that concentrations of triglyceride and cholesterol in each lipoprotein, except for HDL-triglyceride, were markedly elevated in the FAP patient's material, compared to that of the ALS patient. These results suggest that interaction of amyloid fibrils with HDL may play an important role in amyloid formation in FAP.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16690496</pmid><doi>10.1080/13506120500537137</doi><tpages>4</tpages></addata></record> |
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| ispartof | Amyloid, 2006-03, Vol.13 (1), p.20-23 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adult amyloid Amyloid - chemistry Amyloid - metabolism Amyloid - physiology Amyloid Neuropathies, Familial - metabolism Amyloid Neuropathies, Familial - pathology Cholesterol, HDL - metabolism dialysis familial amyloidotic polyneuropathy Female HDL Humans Lipid Metabolism - physiology Lipids Male Middle Aged related amyloidosis Renal Dialysis - adverse effects Triglycerides - metabolism |
| title | Lipid droplets are present in amyloid deposits in familial amyloidotic polyneuropathy and dialysis related amyloidosis |
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