Congenital Cytomegalovirus Infection: Association between Virus Burden in Infancy and Hearing Loss
To determine the relationship between the virus burden in infancy and hearing loss in congenital CMV infection. A cohort of 76 infants with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyz...
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| Veröffentlicht in: | The Journal of pediatrics 2005-06, Vol.146 (6), p.817-823 |
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| container_title | The Journal of pediatrics |
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| creator | Boppana, Suresh B. Fowler, Karen B. Pass, Robert F. Rivera, Lisa B. Bradford, Russell D. Lakeman, Fred D. Britt, William J. |
| description | To determine the relationship between the virus burden in infancy and hearing loss in congenital CMV infection.
A cohort of 76 infants with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyzed in urine specimens obtained during early infancy. Peripheral blood (PB) samples obtained during early infancy were available from 75 children and CMV DNA was quantitated with a real-time quantitative polymerase chain reaction.
Infants with clinical abnormalities at birth (symptomatic congenital CMV infection) had higher amounts of CMV in urine (
P
=
.005) and CMV DNA in PB (
P
=
.001) than infants with no symptoms. Eight children with and 4 children without symptoms had hearing loss. Among children without symptoms, those with hearing loss had a significantly greater amount of CMV in urine (
P
=
.03) and PB virus burden (
P
=
.02) during infancy than those with normal hearing. Infants with |
| doi_str_mv | 10.1016/j.jpeds.2005.01.059 |
| format | Article |
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A cohort of 76 infants with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyzed in urine specimens obtained during early infancy. Peripheral blood (PB) samples obtained during early infancy were available from 75 children and CMV DNA was quantitated with a real-time quantitative polymerase chain reaction.
Infants with clinical abnormalities at birth (symptomatic congenital CMV infection) had higher amounts of CMV in urine (
P
=
.005) and CMV DNA in PB (
P
=
.001) than infants with no symptoms. Eight children with and 4 children without symptoms had hearing loss. Among children without symptoms, those with hearing loss had a significantly greater amount of CMV in urine (
P
=
.03) and PB virus burden (
P
=
.02) during infancy than those with normal hearing. Infants with <5 × 10
3 pfu/mL of urine CMV and infants with <1 × 10
4 copies/mL of viral DNA in PB were at a lower risk for hearing loss.
In children with asymptomatic congenital CMV infection, hearing loss was associated with increased amounts of urine CMV and PB CMV DNA during early infancy.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2005.01.059</identifier><identifier>PMID: 15973325</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Audiometry ; Biological and medical sciences ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - congenital ; Cytomegalovirus Infections - urine ; DNA, Viral - blood ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Evoked Potentials, Auditory, Brain Stem ; Female ; Follow-Up Studies ; General aspects ; Hearing Loss, Sensorineural - virology ; Humans ; Infant ; Male ; Medical sciences ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Polymerase Chain Reaction ; Prospective Studies ; Viral Load</subject><ispartof>The Journal of pediatrics, 2005-06, Vol.146 (6), p.817-823</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-4386c87efccd534f9e530447186fceb4fbd7edcc9eb1a4cd15c6be489edc3fd63</citedby><cites>FETCH-LOGICAL-c387t-4386c87efccd534f9e530447186fceb4fbd7edcc9eb1a4cd15c6be489edc3fd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2005.01.059$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16930438$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15973325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boppana, Suresh B.</creatorcontrib><creatorcontrib>Fowler, Karen B.</creatorcontrib><creatorcontrib>Pass, Robert F.</creatorcontrib><creatorcontrib>Rivera, Lisa B.</creatorcontrib><creatorcontrib>Bradford, Russell D.</creatorcontrib><creatorcontrib>Lakeman, Fred D.</creatorcontrib><creatorcontrib>Britt, William J.</creatorcontrib><title>Congenital Cytomegalovirus Infection: Association between Virus Burden in Infancy and Hearing Loss</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To determine the relationship between the virus burden in infancy and hearing loss in congenital CMV infection.
A cohort of 76 infants with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyzed in urine specimens obtained during early infancy. Peripheral blood (PB) samples obtained during early infancy were available from 75 children and CMV DNA was quantitated with a real-time quantitative polymerase chain reaction.
Infants with clinical abnormalities at birth (symptomatic congenital CMV infection) had higher amounts of CMV in urine (
P
=
.005) and CMV DNA in PB (
P
=
.001) than infants with no symptoms. Eight children with and 4 children without symptoms had hearing loss. Among children without symptoms, those with hearing loss had a significantly greater amount of CMV in urine (
P
=
.03) and PB virus burden (
P
=
.02) during infancy than those with normal hearing. Infants with <5 × 10
3 pfu/mL of urine CMV and infants with <1 × 10
4 copies/mL of viral DNA in PB were at a lower risk for hearing loss.
In children with asymptomatic congenital CMV infection, hearing loss was associated with increased amounts of urine CMV and PB CMV DNA during early infancy.</description><subject>Audiometry</subject><subject>Biological and medical sciences</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - congenital</subject><subject>Cytomegalovirus Infections - urine</subject><subject>DNA, Viral - blood</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Evoked Potentials, Auditory, Brain Stem</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Hearing Loss, Sensorineural - virology</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymerase Chain Reaction</subject><subject>Prospective Studies</subject><subject>Viral Load</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVJaZy0v6AQ9pLediOttNKq0ENqmg8w9NL2KrTSyMisJUfaTfC_rxwbcstpeIdnhpkHoa8ENwQTfrNpNjuwuWkx7hpMGtzJD2hBsBQ17yk9QwuM27amTPBzdJHzBmMsGcaf0DnppKC07RZoWMawhuAnPVbL_RS3sNZjfPZpztVjcGAmH8P36jbnaLw-hGqA6QUgVP9eoZ9zsiX4cMB1MPtKB1s9gE4-rKtVzPkz-uj0mOHLqV6iv3e__iwf6tXv-8fl7ao2tBdTzWjPTS_AGWM7ypyEjmLGBOm5MzAwN1gB1hgJA9HMWNIZPgDrZWlSZzm9RN-Oe3cpPs2QJ7X12cA46gBxzooLyVtBWAHpETSpnJfAqV3yW532imB1UKs26lWtOqhVmKiitkxdndbPwxbs28zJZQGuT4DORo8uFRs-v3Fcln9oX7gfRw6KjGcPSWXjIRiwPhXfykb_7iH_AT5Imp8</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Boppana, Suresh B.</creator><creator>Fowler, Karen B.</creator><creator>Pass, Robert F.</creator><creator>Rivera, Lisa B.</creator><creator>Bradford, Russell D.</creator><creator>Lakeman, Fred D.</creator><creator>Britt, William J.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Congenital Cytomegalovirus Infection: Association between Virus Burden in Infancy and Hearing Loss</title><author>Boppana, Suresh B. ; Fowler, Karen B. ; Pass, Robert F. ; Rivera, Lisa B. ; Bradford, Russell D. ; Lakeman, Fred D. ; Britt, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-4386c87efccd534f9e530447186fceb4fbd7edcc9eb1a4cd15c6be489edc3fd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Audiometry</topic><topic>Biological and medical sciences</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Cytomegalovirus Infections - congenital</topic><topic>Cytomegalovirus Infections - urine</topic><topic>DNA, Viral - blood</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Evoked Potentials, Auditory, Brain Stem</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Hearing Loss, Sensorineural - virology</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymerase Chain Reaction</topic><topic>Prospective Studies</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boppana, Suresh B.</creatorcontrib><creatorcontrib>Fowler, Karen B.</creatorcontrib><creatorcontrib>Pass, Robert F.</creatorcontrib><creatorcontrib>Rivera, Lisa B.</creatorcontrib><creatorcontrib>Bradford, Russell D.</creatorcontrib><creatorcontrib>Lakeman, Fred D.</creatorcontrib><creatorcontrib>Britt, William J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boppana, Suresh B.</au><au>Fowler, Karen B.</au><au>Pass, Robert F.</au><au>Rivera, Lisa B.</au><au>Bradford, Russell D.</au><au>Lakeman, Fred D.</au><au>Britt, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Congenital Cytomegalovirus Infection: Association between Virus Burden in Infancy and Hearing Loss</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>146</volume><issue>6</issue><spage>817</spage><epage>823</epage><pages>817-823</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>To determine the relationship between the virus burden in infancy and hearing loss in congenital CMV infection.
A cohort of 76 infants with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyzed in urine specimens obtained during early infancy. Peripheral blood (PB) samples obtained during early infancy were available from 75 children and CMV DNA was quantitated with a real-time quantitative polymerase chain reaction.
Infants with clinical abnormalities at birth (symptomatic congenital CMV infection) had higher amounts of CMV in urine (
P
=
.005) and CMV DNA in PB (
P
=
.001) than infants with no symptoms. Eight children with and 4 children without symptoms had hearing loss. Among children without symptoms, those with hearing loss had a significantly greater amount of CMV in urine (
P
=
.03) and PB virus burden (
P
=
.02) during infancy than those with normal hearing. Infants with <5 × 10
3 pfu/mL of urine CMV and infants with <1 × 10
4 copies/mL of viral DNA in PB were at a lower risk for hearing loss.
In children with asymptomatic congenital CMV infection, hearing loss was associated with increased amounts of urine CMV and PB CMV DNA during early infancy.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15973325</pmid><doi>10.1016/j.jpeds.2005.01.059</doi><tpages>7</tpages></addata></record> |
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| subjects | Audiometry Biological and medical sciences Cytomegalovirus Infections - complications Cytomegalovirus Infections - congenital Cytomegalovirus Infections - urine DNA, Viral - blood Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Evoked Potentials, Auditory, Brain Stem Female Follow-Up Studies General aspects Hearing Loss, Sensorineural - virology Humans Infant Male Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Polymerase Chain Reaction Prospective Studies Viral Load |
| title | Congenital Cytomegalovirus Infection: Association between Virus Burden in Infancy and Hearing Loss |
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