Determinants of quality of life in chronic liver patients
Summary Background and aim Health‐related quality of life of patients with chronic liver disease has been shown to be impaired in numerous studies. However, the factors which influence health‐related quality of life in treated chronic liver patients are not quite known. This is the first study to as...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2006-06, Vol.23 (11), p.1629-1635 |
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| container_title | Alimentary pharmacology & therapeutics |
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| creator | GUTTELING, J. J. DE MAN, R. A. VAN DER PLAS, S. M. SCHALM, S. W. BUSSCHBACH, J. J. V. DARLINGTON, A.‐S. E. |
| description | Summary
Background and aim
Health‐related quality of life of patients with chronic liver disease has been shown to be impaired in numerous studies. However, the factors which influence health‐related quality of life in treated chronic liver patients are not quite known. This is the first study to assess the impact of physical and psychosocial determinants on a weighted score of health‐related quality of life in patients with chronic liver disease.
Methods
The data of 1175 chronic liver patients were used to assess the relationship between items of the disease‐specific Liver Disease Symptom Index 2.0 and the Short Form (SF)‐6D weighted utility score by means of linear regression analyses.
Results
Health‐related quality of life was most strongly related to disease severity (B = −0.029) and joint pain (B = −0.023). Depression (B = −0.014), pain in the right upper abdomen (B = −0.014), decreased appetite (B = 0.014) and fatigue (B = −0.013) were also strongly related to health‐related quality of life. In hepatitis C virus patients, disease severity (B = −0.037) and depression (B = −0.030) were strong determinants of health‐related quality of life.
Conclusions
This study shows that health‐related quality of life in chronic liver patients is clearly determined by disease severity, joint pain, depression, decreased appetite and fatigue. These patients may benefit most from interventions aimed at improving adaptation to the symptoms described. |
| doi_str_mv | 10.1111/j.1365-2036.2006.02934.x |
| format | Article |
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Background and aim
Health‐related quality of life of patients with chronic liver disease has been shown to be impaired in numerous studies. However, the factors which influence health‐related quality of life in treated chronic liver patients are not quite known. This is the first study to assess the impact of physical and psychosocial determinants on a weighted score of health‐related quality of life in patients with chronic liver disease.
Methods
The data of 1175 chronic liver patients were used to assess the relationship between items of the disease‐specific Liver Disease Symptom Index 2.0 and the Short Form (SF)‐6D weighted utility score by means of linear regression analyses.
Results
Health‐related quality of life was most strongly related to disease severity (B = −0.029) and joint pain (B = −0.023). Depression (B = −0.014), pain in the right upper abdomen (B = −0.014), decreased appetite (B = 0.014) and fatigue (B = −0.013) were also strongly related to health‐related quality of life. In hepatitis C virus patients, disease severity (B = −0.037) and depression (B = −0.030) were strong determinants of health‐related quality of life.
Conclusions
This study shows that health‐related quality of life in chronic liver patients is clearly determined by disease severity, joint pain, depression, decreased appetite and fatigue. These patients may benefit most from interventions aimed at improving adaptation to the symptoms described.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2006.02934.x</identifier><identifier>PMID: 16696813</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Activities of Daily Living ; Adaptation, Psychological ; Adult ; Appetite - physiology ; Arthralgia - etiology ; Biological and medical sciences ; Chronic Disease ; Depressive Disorder - etiology ; Digestive system ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis C virus ; Humans ; Liver Diseases - psychology ; Liver Diseases - therapy ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Quality of Life ; Regression Analysis ; Severity of Illness Index</subject><ispartof>Alimentary pharmacology & therapeutics, 2006-06, Vol.23 (11), p.1629-1635</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4944-c81ee32aa1077b75247d5e2eda4e1c5fd416cea9b72a7504015b6741421cdaf3</citedby><cites>FETCH-LOGICAL-c4944-c81ee32aa1077b75247d5e2eda4e1c5fd416cea9b72a7504015b6741421cdaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2006.02934.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2006.02934.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17781711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16696813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GUTTELING, J. J.</creatorcontrib><creatorcontrib>DE MAN, R. A.</creatorcontrib><creatorcontrib>VAN DER PLAS, S. M.</creatorcontrib><creatorcontrib>SCHALM, S. W.</creatorcontrib><creatorcontrib>BUSSCHBACH, J. J. V.</creatorcontrib><creatorcontrib>DARLINGTON, A.‐S. E.</creatorcontrib><title>Determinants of quality of life in chronic liver patients</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background and aim
Health‐related quality of life of patients with chronic liver disease has been shown to be impaired in numerous studies. However, the factors which influence health‐related quality of life in treated chronic liver patients are not quite known. This is the first study to assess the impact of physical and psychosocial determinants on a weighted score of health‐related quality of life in patients with chronic liver disease.
Methods
The data of 1175 chronic liver patients were used to assess the relationship between items of the disease‐specific Liver Disease Symptom Index 2.0 and the Short Form (SF)‐6D weighted utility score by means of linear regression analyses.
Results
Health‐related quality of life was most strongly related to disease severity (B = −0.029) and joint pain (B = −0.023). Depression (B = −0.014), pain in the right upper abdomen (B = −0.014), decreased appetite (B = 0.014) and fatigue (B = −0.013) were also strongly related to health‐related quality of life. In hepatitis C virus patients, disease severity (B = −0.037) and depression (B = −0.030) were strong determinants of health‐related quality of life.
Conclusions
This study shows that health‐related quality of life in chronic liver patients is clearly determined by disease severity, joint pain, depression, decreased appetite and fatigue. These patients may benefit most from interventions aimed at improving adaptation to the symptoms described.</description><subject>Activities of Daily Living</subject><subject>Adaptation, Psychological</subject><subject>Adult</subject><subject>Appetite - physiology</subject><subject>Arthralgia - etiology</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Depressive Disorder - etiology</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>Liver Diseases - psychology</subject><subject>Liver Diseases - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Quality of Life</subject><subject>Regression Analysis</subject><subject>Severity of Illness Index</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkLtOwzAUQC0EoqXwCygLbAm249jJwFCVp1QJhu6W49wIV3m0dgLt3-PQiI7gxffa5z50EAoIjog_d-uIxDwJKY55RDHmEaZZzKLdCZr-fpyiKaY8C2lK4gm6cG6NPSkwPUcTwnnG_fsUZQ_Qga1No5rOBW0ZbHtVmW4_hJUpITBNoD9s2xjt80-wwUZ1Bjx8ic5KVTm4Gu8ZWj09rhYv4fLt-XUxX4aaZYyFOiUAMVWKYCFykVAmigQoFIoB0UlZMMI1qCwXVIkEM0ySnAtGGCW6UGU8Q7eHthvbbntwnayN01BVqoG2d5KLjFPMsz9BilMeC5F4MD2A2rbOWSjlxppa2b0kWA565VoOFuVgUQ565Y9eufOl1-OMPq-hOBaOPj1wMwLKaVWVVjXauCMnREoEIZ67P3BfpoL9vxeQ8_fVEMXfjIeUpQ</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>GUTTELING, J. J.</creator><creator>DE MAN, R. A.</creator><creator>VAN DER PLAS, S. M.</creator><creator>SCHALM, S. W.</creator><creator>BUSSCHBACH, J. J. V.</creator><creator>DARLINGTON, A.‐S. E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200606</creationdate><title>Determinants of quality of life in chronic liver patients</title><author>GUTTELING, J. J. ; DE MAN, R. A. ; VAN DER PLAS, S. M. ; SCHALM, S. W. ; BUSSCHBACH, J. J. V. ; DARLINGTON, A.‐S. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4944-c81ee32aa1077b75247d5e2eda4e1c5fd416cea9b72a7504015b6741421cdaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Activities of Daily Living</topic><topic>Adaptation, Psychological</topic><topic>Adult</topic><topic>Appetite - physiology</topic><topic>Arthralgia - etiology</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Depressive Disorder - etiology</topic><topic>Digestive system</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis C virus</topic><topic>Humans</topic><topic>Liver Diseases - psychology</topic><topic>Liver Diseases - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Quality of Life</topic><topic>Regression Analysis</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GUTTELING, J. J.</creatorcontrib><creatorcontrib>DE MAN, R. A.</creatorcontrib><creatorcontrib>VAN DER PLAS, S. M.</creatorcontrib><creatorcontrib>SCHALM, S. W.</creatorcontrib><creatorcontrib>BUSSCHBACH, J. J. V.</creatorcontrib><creatorcontrib>DARLINGTON, A.‐S. E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GUTTELING, J. J.</au><au>DE MAN, R. A.</au><au>VAN DER PLAS, S. M.</au><au>SCHALM, S. W.</au><au>BUSSCHBACH, J. J. V.</au><au>DARLINGTON, A.‐S. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of quality of life in chronic liver patients</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2006-06</date><risdate>2006</risdate><volume>23</volume><issue>11</issue><spage>1629</spage><epage>1635</epage><pages>1629-1635</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background and aim
Health‐related quality of life of patients with chronic liver disease has been shown to be impaired in numerous studies. However, the factors which influence health‐related quality of life in treated chronic liver patients are not quite known. This is the first study to assess the impact of physical and psychosocial determinants on a weighted score of health‐related quality of life in patients with chronic liver disease.
Methods
The data of 1175 chronic liver patients were used to assess the relationship between items of the disease‐specific Liver Disease Symptom Index 2.0 and the Short Form (SF)‐6D weighted utility score by means of linear regression analyses.
Results
Health‐related quality of life was most strongly related to disease severity (B = −0.029) and joint pain (B = −0.023). Depression (B = −0.014), pain in the right upper abdomen (B = −0.014), decreased appetite (B = 0.014) and fatigue (B = −0.013) were also strongly related to health‐related quality of life. In hepatitis C virus patients, disease severity (B = −0.037) and depression (B = −0.030) were strong determinants of health‐related quality of life.
Conclusions
This study shows that health‐related quality of life in chronic liver patients is clearly determined by disease severity, joint pain, depression, decreased appetite and fatigue. These patients may benefit most from interventions aimed at improving adaptation to the symptoms described.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16696813</pmid><doi>10.1111/j.1365-2036.2006.02934.x</doi><tpages>7</tpages></addata></record> |
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| source | Wiley-Blackwell Journals; Wiley-Blackwell Backfiles (Open access); MEDLINE; IngentaConnect Open Access; EZB Electronic Journals Library |
| subjects | Activities of Daily Living Adaptation, Psychological Adult Appetite - physiology Arthralgia - etiology Biological and medical sciences Chronic Disease Depressive Disorder - etiology Digestive system Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis C virus Humans Liver Diseases - psychology Liver Diseases - therapy Male Medical sciences Middle Aged Pharmacology. Drug treatments Quality of Life Regression Analysis Severity of Illness Index |
| title | Determinants of quality of life in chronic liver patients |
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