Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides
A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema...
Gespeichert in:
| Veröffentlicht in: | Archives of pharmacal research 2005-05, Vol.28 (5), p.509-517 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 517 |
|---|---|
| container_issue | 5 |
| container_start_page | 509 |
| container_title | Archives of pharmacal research |
| container_volume | 28 |
| creator | Süküroglu, Murat Caliskan Ergün, Burcu Unlü, Serdar Sahin, M Fethi Küpeli, Esra Yesilada, Erdem Banoglu, Erden |
| description | A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds. |
| doi_str_mv | 10.1007/BF02977751 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67961644</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67961644</sourcerecordid><originalsourceid>FETCH-LOGICAL-c285t-7d32ef5e2a5baab6e19ef4f9bfb7db251532805d430fa35dcff9313bdfde173f3</originalsourceid><addsrcrecordid>eNpFkE1LAzEURYMotlY3_gDpSqwYzcck6SxV1AqCC3UlMmQmLzaSmdRJKoxb_7hTWuji8S6Xw10chI4puaSEqKube8JypZSgO2hIcyUxV1O5i4aECY4lk_kAHcT4RQiXQoh9NKAiV1nGxRD9vXRNmkN08WKsG-0_-1itoukvOewa63Vd6xTabqyr5H5cchDHwY7fJT7jFwIbV0Oadx5nuJr70IZF1-rf4AFT3PkJ5mdsNsF96Yz-dU1oMOv7D11B0rUzEA_RntU-wtHmj9Db_d3r7Qw_PT883l4_4YpNRcLKcAZWANOi1LqUQHOwmc1LWypTMkEFZ1MiTMaJ1VyYytqcU14aa4AqbvkIna53F234XkJMRe1iBd7rBsIyFlLlksreywidr8GqDTG2YItF62rddgUlxUp5sVXewyeb1WVZg9miG8f8HwzPfMs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67961644</pqid></control><display><type>article</type><title>Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Süküroglu, Murat ; Caliskan Ergün, Burcu ; Unlü, Serdar ; Sahin, M Fethi ; Küpeli, Esra ; Yesilada, Erdem ; Banoglu, Erden</creator><creatorcontrib>Süküroglu, Murat ; Caliskan Ergün, Burcu ; Unlü, Serdar ; Sahin, M Fethi ; Küpeli, Esra ; Yesilada, Erdem ; Banoglu, Erden</creatorcontrib><description>A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.</description><identifier>ISSN: 0253-6269</identifier><identifier>EISSN: 1976-3786</identifier><identifier>DOI: 10.1007/BF02977751</identifier><identifier>PMID: 15974435</identifier><language>eng</language><publisher>Korea (South)</publisher><subject>Acetamides - chemical synthesis ; Acetamides - pharmacology ; Analgesics - chemical synthesis ; Analgesics - pharmacology ; Animals ; Anti-Inflammatory Agents - chemical synthesis ; Anti-Inflammatory Agents - pharmacology ; Mice ; Pyrazoles - chemical synthesis ; Pyrazoles - pharmacology ; Pyridazines - chemical synthesis ; Pyridazines - pharmacology</subject><ispartof>Archives of pharmacal research, 2005-05, Vol.28 (5), p.509-517</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c285t-7d32ef5e2a5baab6e19ef4f9bfb7db251532805d430fa35dcff9313bdfde173f3</citedby><cites>FETCH-LOGICAL-c285t-7d32ef5e2a5baab6e19ef4f9bfb7db251532805d430fa35dcff9313bdfde173f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15974435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Süküroglu, Murat</creatorcontrib><creatorcontrib>Caliskan Ergün, Burcu</creatorcontrib><creatorcontrib>Unlü, Serdar</creatorcontrib><creatorcontrib>Sahin, M Fethi</creatorcontrib><creatorcontrib>Küpeli, Esra</creatorcontrib><creatorcontrib>Yesilada, Erdem</creatorcontrib><creatorcontrib>Banoglu, Erden</creatorcontrib><title>Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides</title><title>Archives of pharmacal research</title><addtitle>Arch Pharm Res</addtitle><description>A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.</description><subject>Acetamides - chemical synthesis</subject><subject>Acetamides - pharmacology</subject><subject>Analgesics - chemical synthesis</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - chemical synthesis</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Mice</subject><subject>Pyrazoles - chemical synthesis</subject><subject>Pyrazoles - pharmacology</subject><subject>Pyridazines - chemical synthesis</subject><subject>Pyridazines - pharmacology</subject><issn>0253-6269</issn><issn>1976-3786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEURYMotlY3_gDpSqwYzcck6SxV1AqCC3UlMmQmLzaSmdRJKoxb_7hTWuji8S6Xw10chI4puaSEqKube8JypZSgO2hIcyUxV1O5i4aECY4lk_kAHcT4RQiXQoh9NKAiV1nGxRD9vXRNmkN08WKsG-0_-1itoukvOewa63Vd6xTabqyr5H5cchDHwY7fJT7jFwIbV0Oadx5nuJr70IZF1-rf4AFT3PkJ5mdsNsF96Yz-dU1oMOv7D11B0rUzEA_RntU-wtHmj9Db_d3r7Qw_PT883l4_4YpNRcLKcAZWANOi1LqUQHOwmc1LWypTMkEFZ1MiTMaJ1VyYytqcU14aa4AqbvkIna53F234XkJMRe1iBd7rBsIyFlLlksreywidr8GqDTG2YItF62rddgUlxUp5sVXewyeb1WVZg9miG8f8HwzPfMs</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Süküroglu, Murat</creator><creator>Caliskan Ergün, Burcu</creator><creator>Unlü, Serdar</creator><creator>Sahin, M Fethi</creator><creator>Küpeli, Esra</creator><creator>Yesilada, Erdem</creator><creator>Banoglu, Erden</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides</title><author>Süküroglu, Murat ; Caliskan Ergün, Burcu ; Unlü, Serdar ; Sahin, M Fethi ; Küpeli, Esra ; Yesilada, Erdem ; Banoglu, Erden</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-7d32ef5e2a5baab6e19ef4f9bfb7db251532805d430fa35dcff9313bdfde173f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetamides - chemical synthesis</topic><topic>Acetamides - pharmacology</topic><topic>Analgesics - chemical synthesis</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - chemical synthesis</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Mice</topic><topic>Pyrazoles - chemical synthesis</topic><topic>Pyrazoles - pharmacology</topic><topic>Pyridazines - chemical synthesis</topic><topic>Pyridazines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Süküroglu, Murat</creatorcontrib><creatorcontrib>Caliskan Ergün, Burcu</creatorcontrib><creatorcontrib>Unlü, Serdar</creatorcontrib><creatorcontrib>Sahin, M Fethi</creatorcontrib><creatorcontrib>Küpeli, Esra</creatorcontrib><creatorcontrib>Yesilada, Erdem</creatorcontrib><creatorcontrib>Banoglu, Erden</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of pharmacal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Süküroglu, Murat</au><au>Caliskan Ergün, Burcu</au><au>Unlü, Serdar</au><au>Sahin, M Fethi</au><au>Küpeli, Esra</au><au>Yesilada, Erdem</au><au>Banoglu, Erden</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides</atitle><jtitle>Archives of pharmacal research</jtitle><addtitle>Arch Pharm Res</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>28</volume><issue>5</issue><spage>509</spage><epage>517</epage><pages>509-517</pages><issn>0253-6269</issn><eissn>1976-3786</eissn><abstract>A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.</abstract><cop>Korea (South)</cop><pmid>15974435</pmid><doi>10.1007/BF02977751</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0253-6269 |
| ispartof | Archives of pharmacal research, 2005-05, Vol.28 (5), p.509-517 |
| issn | 0253-6269 1976-3786 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67961644 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetamides - chemical synthesis Acetamides - pharmacology Analgesics - chemical synthesis Analgesics - pharmacology Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - pharmacology Mice Pyrazoles - chemical synthesis Pyrazoles - pharmacology Pyridazines - chemical synthesis Pyridazines - pharmacology |
| title | Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T08%3A31%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis,%20analgesic,%20and%20anti-inflammatory%20activities%20of%20%5B6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl%5Dacetamides&rft.jtitle=Archives%20of%20pharmacal%20research&rft.au=S%C3%BCk%C3%BCroglu,%20Murat&rft.date=2005-05-01&rft.volume=28&rft.issue=5&rft.spage=509&rft.epage=517&rft.pages=509-517&rft.issn=0253-6269&rft.eissn=1976-3786&rft_id=info:doi/10.1007/BF02977751&rft_dat=%3Cproquest_cross%3E67961644%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67961644&rft_id=info:pmid/15974435&rfr_iscdi=true |