Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation
The p.N680S sequence variation of the follicle-stimulating hormone (FSH) receptor gene was previously shown to influence the ovarian response to FSH in normo-ovulatory women undergoing controlled ovarian hyperstimulation. In this prospective, randomized, controlled study, we tested whether the same...
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| Veröffentlicht in: | Pharmacogenetics and genomics 2005-07, Vol.15 (7), p.451-456 |
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| creator | Behre, Hermann M Greb, Robert R Mempel, Andrea Sonntag, Barbara Kiesel, Ludwig Kaltwaer, Petra Seliger, Ewald Röpke, Friedrich Gromoll, Jörg Nieschlag, Eberhard Simoni, Manuela |
| description | The p.N680S sequence variation of the follicle-stimulating hormone (FSH) receptor gene was previously shown to influence the ovarian response to FSH in normo-ovulatory women undergoing controlled ovarian hyperstimulation. In this prospective, randomized, controlled study, we tested whether the same daily dose of FSH results in lower levels of oestradiol in women homozygous for the p.N680S sequence variation, and whether the difference can be overcome by higher FSH doses. Women undergoing controlled ovarian hyperstimulation for in vitro fertilization or intracytoplasmic sperm injection and homozygous for the wild-type or for the p.N680S FSH receptor were randomly assigned to group I (Ser/Ser, n=24), receiving an FSH dose of 150 U/day, or group II (Ser/Ser, n=25), receiving an FSH dose of 225 U/day. In group III (Asn/Asn, n=44), the FSH dose was 150 U/day. Age and basal FSH levels were not different between groups. At ovulation induction, total FSH doses were comparable in group I (1631±96 U) and group III (1640±57 U) but significantly higher in group II (2421±112 U) (P |
| doi_str_mv | 10.1097/01.fpc.0000167330.92786.5e |
| format | Article |
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In this prospective, randomized, controlled study, we tested whether the same daily dose of FSH results in lower levels of oestradiol in women homozygous for the p.N680S sequence variation, and whether the difference can be overcome by higher FSH doses. Women undergoing controlled ovarian hyperstimulation for in vitro fertilization or intracytoplasmic sperm injection and homozygous for the wild-type or for the p.N680S FSH receptor were randomly assigned to group I (Ser/Ser, n=24), receiving an FSH dose of 150 U/day, or group II (Ser/Ser, n=25), receiving an FSH dose of 225 U/day. In group III (Asn/Asn, n=44), the FSH dose was 150 U/day. Age and basal FSH levels were not different between groups. At ovulation induction, total FSH doses were comparable in group I (1631±96 U) and group III (1640±57 U) but significantly higher in group II (2421±112 U) (P<0.001). Peak oestradiol levels on the day of human chorionic gonadotrophin (hCG) administration were significantly lower in group I (5680±675 pmol/l) compared to group III (8679±804 pmol/l) (P=0.028). Increasing the FSH dose from 150 to 225 U/day overcame the lower oestradiol response in women with Ser/Ser (group II, 7804±983 pmol/l). In women undergoing controlled ovarian hyperstimulation, the p.N680S sequence variation results in lower oestradiol levels following FSH stimulation. This lower FSH receptor sensitivity can be overcome by higher FSH doses.</description><identifier>ISSN: 1744-6872</identifier><identifier>EISSN: 1744-6880</identifier><identifier>DOI: 10.1097/01.fpc.0000167330.92786.5e</identifier><identifier>PMID: 15970792</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cell receptors ; Cell structures and functions ; Chorionic Gonadotropin - therapeutic use ; Estradiol - secretion ; Exons - genetics ; Female ; Follicle Stimulating Hormone, Human - blood ; Follicle Stimulating Hormone, Human - therapeutic use ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Genotype ; Humans ; Medical sciences ; Miscellaneous ; Molecular and cellular biology ; Ovary - drug effects ; Ovary - physiology ; Ovulation Induction ; Pharmacogenetics ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Prospective Studies ; Receptors, FSH - genetics ; Recombinant Proteins - therapeutic use</subject><ispartof>Pharmacogenetics and genomics, 2005-07, Vol.15 (7), p.451-456</ispartof><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4582-2d0145d8a6281a658c8f6d2d3764f932f9fef2253b7e1179d7025e17346bffca3</citedby><cites>FETCH-LOGICAL-c4582-2d0145d8a6281a658c8f6d2d3764f932f9fef2253b7e1179d7025e17346bffca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16915107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15970792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Behre, Hermann M</creatorcontrib><creatorcontrib>Greb, Robert R</creatorcontrib><creatorcontrib>Mempel, Andrea</creatorcontrib><creatorcontrib>Sonntag, Barbara</creatorcontrib><creatorcontrib>Kiesel, Ludwig</creatorcontrib><creatorcontrib>Kaltwaer, Petra</creatorcontrib><creatorcontrib>Seliger, Ewald</creatorcontrib><creatorcontrib>Röpke, Friedrich</creatorcontrib><creatorcontrib>Gromoll, Jörg</creatorcontrib><creatorcontrib>Nieschlag, Eberhard</creatorcontrib><creatorcontrib>Simoni, Manuela</creatorcontrib><title>Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation</title><title>Pharmacogenetics and genomics</title><addtitle>Pharmacogenet Genomics</addtitle><description>The p.N680S sequence variation of the follicle-stimulating hormone (FSH) receptor gene was previously shown to influence the ovarian response to FSH in normo-ovulatory women undergoing controlled ovarian hyperstimulation. In this prospective, randomized, controlled study, we tested whether the same daily dose of FSH results in lower levels of oestradiol in women homozygous for the p.N680S sequence variation, and whether the difference can be overcome by higher FSH doses. Women undergoing controlled ovarian hyperstimulation for in vitro fertilization or intracytoplasmic sperm injection and homozygous for the wild-type or for the p.N680S FSH receptor were randomly assigned to group I (Ser/Ser, n=24), receiving an FSH dose of 150 U/day, or group II (Ser/Ser, n=25), receiving an FSH dose of 225 U/day. In group III (Asn/Asn, n=44), the FSH dose was 150 U/day. Age and basal FSH levels were not different between groups. At ovulation induction, total FSH doses were comparable in group I (1631±96 U) and group III (1640±57 U) but significantly higher in group II (2421±112 U) (P<0.001). Peak oestradiol levels on the day of human chorionic gonadotrophin (hCG) administration were significantly lower in group I (5680±675 pmol/l) compared to group III (8679±804 pmol/l) (P=0.028). Increasing the FSH dose from 150 to 225 U/day overcame the lower oestradiol response in women with Ser/Ser (group II, 7804±983 pmol/l). In women undergoing controlled ovarian hyperstimulation, the p.N680S sequence variation results in lower oestradiol levels following FSH stimulation. This lower FSH receptor sensitivity can be overcome by higher FSH doses.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Chorionic Gonadotropin - therapeutic use</subject><subject>Estradiol - secretion</subject><subject>Exons - genetics</subject><subject>Female</subject><subject>Follicle Stimulating Hormone, Human - blood</subject><subject>Follicle Stimulating Hormone, Human - therapeutic use</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Ovary - drug effects</subject><subject>Ovary - physiology</subject><subject>Ovulation Induction</subject><subject>Pharmacogenetics</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Receptors, FSH - genetics</subject><subject>Recombinant Proteins - therapeutic use</subject><issn>1744-6872</issn><issn>1744-6880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkcFu1DAURSMEoqXwC8hCApVFgu0kdtIdqlqKVIlFYW15nOeJwbGD7VDmY_kXnM5oxhtbeufed-VbFO8Irgju-SdMKj2rCudDGK9rXPWUd6xq4VlxTnjTlKzr8PPjm9Oz4lWMPzGuWd_Ql8UZaXuOeU_Pi38PZuuMNko6BchrJJHy0-QdisZtLSC3KAs-mQHQ7O1u8mEeTZyQcQj-ZozgVZVGQNpbazJcxmSmxcqUDdDoQzYDdHn7cPcRBVAwJx_QFtwqCE9C_0cGI12extm7CCh5lPGrnGUeZZik8iufjEJynoOXalwR5V0KeScMR4dxN0M4rvfudfFCSxvhzeG-KH7c3ny_vivvv335ev35vlRN29GSDpg07dBJRjsiWdupTrOBDjVnje5rqnsNmtK23nAghPcDx7QFwuuGbbRWsr4oPux9c7rfC8QkJhMVWCsd-CUKxntGGCUZvNqDKvgYA2gxBzPJsBMEi7VcgYnI5YpTueKpXNFCFr89bFk2Ewwn6aHNDLw_ADIqaXXIpZp44lhPWoJ55po99-htyh_2yy6PEMQI0qYxJ8hBMSElxbjFPAcp1zS0_g9dJ8Mt</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Behre, Hermann M</creator><creator>Greb, Robert R</creator><creator>Mempel, Andrea</creator><creator>Sonntag, Barbara</creator><creator>Kiesel, Ludwig</creator><creator>Kaltwaer, Petra</creator><creator>Seliger, Ewald</creator><creator>Röpke, Friedrich</creator><creator>Gromoll, Jörg</creator><creator>Nieschlag, Eberhard</creator><creator>Simoni, Manuela</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation</title><author>Behre, Hermann M ; Greb, Robert R ; Mempel, Andrea ; Sonntag, Barbara ; Kiesel, Ludwig ; Kaltwaer, Petra ; Seliger, Ewald ; Röpke, Friedrich ; Gromoll, Jörg ; Nieschlag, Eberhard ; Simoni, Manuela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4582-2d0145d8a6281a658c8f6d2d3764f932f9fef2253b7e1179d7025e17346bffca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Chorionic Gonadotropin - therapeutic use</topic><topic>Estradiol - secretion</topic><topic>Exons - genetics</topic><topic>Female</topic><topic>Follicle Stimulating Hormone, Human - blood</topic><topic>Follicle Stimulating Hormone, Human - therapeutic use</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Ovary - drug effects</topic><topic>Ovary - physiology</topic><topic>Ovulation Induction</topic><topic>Pharmacogenetics</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prospective Studies</topic><topic>Receptors, FSH - genetics</topic><topic>Recombinant Proteins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Behre, Hermann M</creatorcontrib><creatorcontrib>Greb, Robert R</creatorcontrib><creatorcontrib>Mempel, Andrea</creatorcontrib><creatorcontrib>Sonntag, Barbara</creatorcontrib><creatorcontrib>Kiesel, Ludwig</creatorcontrib><creatorcontrib>Kaltwaer, Petra</creatorcontrib><creatorcontrib>Seliger, Ewald</creatorcontrib><creatorcontrib>Röpke, Friedrich</creatorcontrib><creatorcontrib>Gromoll, Jörg</creatorcontrib><creatorcontrib>Nieschlag, Eberhard</creatorcontrib><creatorcontrib>Simoni, Manuela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacogenetics and genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Behre, Hermann M</au><au>Greb, Robert R</au><au>Mempel, Andrea</au><au>Sonntag, Barbara</au><au>Kiesel, Ludwig</au><au>Kaltwaer, Petra</au><au>Seliger, Ewald</au><au>Röpke, Friedrich</au><au>Gromoll, Jörg</au><au>Nieschlag, Eberhard</au><au>Simoni, Manuela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation</atitle><jtitle>Pharmacogenetics and genomics</jtitle><addtitle>Pharmacogenet Genomics</addtitle><date>2005-07</date><risdate>2005</risdate><volume>15</volume><issue>7</issue><spage>451</spage><epage>456</epage><pages>451-456</pages><issn>1744-6872</issn><eissn>1744-6880</eissn><abstract>The p.N680S sequence variation of the follicle-stimulating hormone (FSH) receptor gene was previously shown to influence the ovarian response to FSH in normo-ovulatory women undergoing controlled ovarian hyperstimulation. In this prospective, randomized, controlled study, we tested whether the same daily dose of FSH results in lower levels of oestradiol in women homozygous for the p.N680S sequence variation, and whether the difference can be overcome by higher FSH doses. Women undergoing controlled ovarian hyperstimulation for in vitro fertilization or intracytoplasmic sperm injection and homozygous for the wild-type or for the p.N680S FSH receptor were randomly assigned to group I (Ser/Ser, n=24), receiving an FSH dose of 150 U/day, or group II (Ser/Ser, n=25), receiving an FSH dose of 225 U/day. In group III (Asn/Asn, n=44), the FSH dose was 150 U/day. Age and basal FSH levels were not different between groups. At ovulation induction, total FSH doses were comparable in group I (1631±96 U) and group III (1640±57 U) but significantly higher in group II (2421±112 U) (P<0.001). Peak oestradiol levels on the day of human chorionic gonadotrophin (hCG) administration were significantly lower in group I (5680±675 pmol/l) compared to group III (8679±804 pmol/l) (P=0.028). Increasing the FSH dose from 150 to 225 U/day overcame the lower oestradiol response in women with Ser/Ser (group II, 7804±983 pmol/l). In women undergoing controlled ovarian hyperstimulation, the p.N680S sequence variation results in lower oestradiol levels following FSH stimulation. This lower FSH receptor sensitivity can be overcome by higher FSH doses.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15970792</pmid><doi>10.1097/01.fpc.0000167330.92786.5e</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pharmacogenetics and genomics, 2005-07, Vol.15 (7), p.451-456 |
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| subjects | Adolescent Adult Biological and medical sciences Cell receptors Cell structures and functions Chorionic Gonadotropin - therapeutic use Estradiol - secretion Exons - genetics Female Follicle Stimulating Hormone, Human - blood Follicle Stimulating Hormone, Human - therapeutic use Fundamental and applied biological sciences. Psychology General pharmacology Genotype Humans Medical sciences Miscellaneous Molecular and cellular biology Ovary - drug effects Ovary - physiology Ovulation Induction Pharmacogenetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Polymerase Chain Reaction Polymorphism, Single Nucleotide Prospective Studies Receptors, FSH - genetics Recombinant Proteins - therapeutic use |
| title | Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation |
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