Neonatal Renal Venous Thrombosis: Clinical Outcomes and Prevalence of Prothrombotic Disorders
To determine clinical outcomes and the prevalence of prothrombotic conditions in patients who had neonatal renal venous thrombosis (RVT). A retrospective cohort of neonates with RVT who were admitted to 4 pediatric centers from 1980 to 2001 was identified. Information on clinical presentation, labor...
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| Veröffentlicht in: | The Journal of pediatrics 2005-06, Vol.146 (6), p.811-816 |
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| container_title | The Journal of pediatrics |
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| creator | Marks, Stephen D. Massicotte, M. Patricia Steele, Brian T. Matsell, Douglas G. Filler, Guido Shah, Prakesh S. Perlman, Max Rosenblum, Norman D. Shah, Vibhuti S. |
| description | To determine clinical outcomes and the prevalence of prothrombotic conditions in patients who had neonatal renal venous thrombosis (RVT).
A retrospective cohort of neonates with RVT who were admitted to 4 pediatric centers from 1980 to 2001 was identified. Information on clinical presentation, laboratory and radiological investigation, and treatment were abstracted. Survivors were evaluated for renal status and prothrombotic conditions.
Forty-three patients with neonatal RVT were identified. RVT was unilateral in 24 patients (56%) and associated with 2thrombi at other sites in 32 patienets (74%). Clinical presentations included renal failure in 24 patients (56%), thrombocytopenia, anemia, or both in 22 patients (51%), and renal mass in 21 patients (49%). Neonatal interventions included anti-coagulants in 28 patients (65%), antihypertensive medications in 9 patients (21%), peritoneal dialysis in 2 patients (5%), and nephrectomy in 2 patients (5%). The median age at follow-up was 3.7 years (range, 0.5-20.2 years). Thirteen patients (34%) had hypertension, and 11 patients (29%) had renal failure. End-stage renal disease developed in 3 patients, and they underwent live-related renal transplants. Twelve of the 28 patients (43%) examined had prothrombotic abnormalities.
Neonatal RVT is associated with significant renal morbidity and a high prevalence of prothrombotic abnormalities. |
| doi_str_mv | 10.1016/j.jpeds.2005.02.022 |
| format | Article |
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A retrospective cohort of neonates with RVT who were admitted to 4 pediatric centers from 1980 to 2001 was identified. Information on clinical presentation, laboratory and radiological investigation, and treatment were abstracted. Survivors were evaluated for renal status and prothrombotic conditions.
Forty-three patients with neonatal RVT were identified. RVT was unilateral in 24 patients (56%) and associated with 2thrombi at other sites in 32 patienets (74%). Clinical presentations included renal failure in 24 patients (56%), thrombocytopenia, anemia, or both in 22 patients (51%), and renal mass in 21 patients (49%). Neonatal interventions included anti-coagulants in 28 patients (65%), antihypertensive medications in 9 patients (21%), peritoneal dialysis in 2 patients (5%), and nephrectomy in 2 patients (5%). The median age at follow-up was 3.7 years (range, 0.5-20.2 years). Thirteen patients (34%) had hypertension, and 11 patients (29%) had renal failure. End-stage renal disease developed in 3 patients, and they underwent live-related renal transplants. Twelve of the 28 patients (43%) examined had prothrombotic abnormalities.
Neonatal RVT is associated with significant renal morbidity and a high prevalence of prothrombotic abnormalities.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2005.02.022</identifier><identifier>PMID: 15973324</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Anemia, Neonatal - etiology ; Anticoagulants - therapeutic use ; Antihypertensive Agents - therapeutic use ; Atrophy ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Coagulation Disorders, Inherited - epidemiology ; Canada - epidemiology ; Cardiology. Vascular system ; Child ; Child, Preschool ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Follow-Up Studies ; General aspects ; Humans ; Infant ; Infant, Newborn ; Kidney - pathology ; Kidney Transplantation ; Male ; Medical sciences ; Nephrectomy ; Peritoneal Dialysis ; Prevalence ; Prospective Studies ; Renal Insufficiency - etiology ; Renal Insufficiency - surgery ; Renal Veins ; Retrospective Studies ; Thrombocytopenia - etiology ; Venous Thrombosis - diagnosis ; Venous Thrombosis - epidemiology ; Venous Thrombosis - therapy</subject><ispartof>The Journal of pediatrics, 2005-06, Vol.146 (6), p.811-816</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-1982d1e6da4e13e37ef1f348d4db0380713b28eb7f92dd040959d5dc5b7c94b73</citedby><cites>FETCH-LOGICAL-c387t-1982d1e6da4e13e37ef1f348d4db0380713b28eb7f92dd040959d5dc5b7c94b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2005.02.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16930437$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15973324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marks, Stephen D.</creatorcontrib><creatorcontrib>Massicotte, M. Patricia</creatorcontrib><creatorcontrib>Steele, Brian T.</creatorcontrib><creatorcontrib>Matsell, Douglas G.</creatorcontrib><creatorcontrib>Filler, Guido</creatorcontrib><creatorcontrib>Shah, Prakesh S.</creatorcontrib><creatorcontrib>Perlman, Max</creatorcontrib><creatorcontrib>Rosenblum, Norman D.</creatorcontrib><creatorcontrib>Shah, Vibhuti S.</creatorcontrib><title>Neonatal Renal Venous Thrombosis: Clinical Outcomes and Prevalence of Prothrombotic Disorders</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To determine clinical outcomes and the prevalence of prothrombotic conditions in patients who had neonatal renal venous thrombosis (RVT).
A retrospective cohort of neonates with RVT who were admitted to 4 pediatric centers from 1980 to 2001 was identified. Information on clinical presentation, laboratory and radiological investigation, and treatment were abstracted. Survivors were evaluated for renal status and prothrombotic conditions.
Forty-three patients with neonatal RVT were identified. RVT was unilateral in 24 patients (56%) and associated with 2thrombi at other sites in 32 patienets (74%). Clinical presentations included renal failure in 24 patients (56%), thrombocytopenia, anemia, or both in 22 patients (51%), and renal mass in 21 patients (49%). Neonatal interventions included anti-coagulants in 28 patients (65%), antihypertensive medications in 9 patients (21%), peritoneal dialysis in 2 patients (5%), and nephrectomy in 2 patients (5%). The median age at follow-up was 3.7 years (range, 0.5-20.2 years). Thirteen patients (34%) had hypertension, and 11 patients (29%) had renal failure. End-stage renal disease developed in 3 patients, and they underwent live-related renal transplants. Twelve of the 28 patients (43%) examined had prothrombotic abnormalities.
Neonatal RVT is associated with significant renal morbidity and a high prevalence of prothrombotic abnormalities.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia, Neonatal - etiology</subject><subject>Anticoagulants - therapeutic use</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Coagulation Disorders, Inherited - epidemiology</subject><subject>Canada - epidemiology</subject><subject>Cardiology. Vascular system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Kidney - pathology</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrectomy</subject><subject>Peritoneal Dialysis</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Renal Insufficiency - etiology</subject><subject>Renal Insufficiency - surgery</subject><subject>Renal Veins</subject><subject>Retrospective Studies</subject><subject>Thrombocytopenia - etiology</subject><subject>Venous Thrombosis - diagnosis</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Venous Thrombosis - therapy</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF2L1DAUhoMo7rj6CwTpjd51PPlo0wheyPgJiyuyeichTU4xQ9vM5nQW_PemzsDeCYeEJM97kjyMPeew5cDb1_vt_oCBtgKg2YIoJR6wDQej67aT8iHbQNmqpdLtBXtCtAcAowAeswveGC2lUBv26yum2S1urL7jXMafOKcjVTe_c5r6RJHeVLsxztGXs-vj4tOEVLk5VN8y3rkRZ49VGsoqLafIEn31PlLKATM9ZY8GNxI-O8-X7MfHDze7z_XV9acvu3dXtZedXmpuOhE4tsEp5BKlxoEPUnVBhR5kB5rLXnTY68GIEECBaUxogm967Y3qtbxkr059DzndHpEWO0XyOI5uxvId22rTcoAVlCfQ50SUcbCHHCeX_1gOdrVq9_afVbtatSBKiZJ6cW5_7CcM95mzxgK8PAOOiqkhu9lHuudaI0HJ9fq3Jw6LjLuI2ZKPq8MQM_rFhhT_-5C_FZ6XKQ</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Marks, Stephen D.</creator><creator>Massicotte, M. Patricia</creator><creator>Steele, Brian T.</creator><creator>Matsell, Douglas G.</creator><creator>Filler, Guido</creator><creator>Shah, Prakesh S.</creator><creator>Perlman, Max</creator><creator>Rosenblum, Norman D.</creator><creator>Shah, Vibhuti S.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Neonatal Renal Venous Thrombosis: Clinical Outcomes and Prevalence of Prothrombotic Disorders</title><author>Marks, Stephen D. ; Massicotte, M. Patricia ; Steele, Brian T. ; Matsell, Douglas G. ; Filler, Guido ; Shah, Prakesh S. ; Perlman, Max ; Rosenblum, Norman D. ; Shah, Vibhuti S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-1982d1e6da4e13e37ef1f348d4db0380713b28eb7f92dd040959d5dc5b7c94b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia, Neonatal - etiology</topic><topic>Anticoagulants - therapeutic use</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Coagulation Disorders, Inherited - epidemiology</topic><topic>Canada - epidemiology</topic><topic>Cardiology. Vascular system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Kidney - pathology</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrectomy</topic><topic>Peritoneal Dialysis</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Renal Insufficiency - etiology</topic><topic>Renal Insufficiency - surgery</topic><topic>Renal Veins</topic><topic>Retrospective Studies</topic><topic>Thrombocytopenia - etiology</topic><topic>Venous Thrombosis - diagnosis</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Venous Thrombosis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marks, Stephen D.</creatorcontrib><creatorcontrib>Massicotte, M. Patricia</creatorcontrib><creatorcontrib>Steele, Brian T.</creatorcontrib><creatorcontrib>Matsell, Douglas G.</creatorcontrib><creatorcontrib>Filler, Guido</creatorcontrib><creatorcontrib>Shah, Prakesh S.</creatorcontrib><creatorcontrib>Perlman, Max</creatorcontrib><creatorcontrib>Rosenblum, Norman D.</creatorcontrib><creatorcontrib>Shah, Vibhuti S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marks, Stephen D.</au><au>Massicotte, M. Patricia</au><au>Steele, Brian T.</au><au>Matsell, Douglas G.</au><au>Filler, Guido</au><au>Shah, Prakesh S.</au><au>Perlman, Max</au><au>Rosenblum, Norman D.</au><au>Shah, Vibhuti S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal Renal Venous Thrombosis: Clinical Outcomes and Prevalence of Prothrombotic Disorders</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>146</volume><issue>6</issue><spage>811</spage><epage>816</epage><pages>811-816</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>To determine clinical outcomes and the prevalence of prothrombotic conditions in patients who had neonatal renal venous thrombosis (RVT).
A retrospective cohort of neonates with RVT who were admitted to 4 pediatric centers from 1980 to 2001 was identified. Information on clinical presentation, laboratory and radiological investigation, and treatment were abstracted. Survivors were evaluated for renal status and prothrombotic conditions.
Forty-three patients with neonatal RVT were identified. RVT was unilateral in 24 patients (56%) and associated with 2thrombi at other sites in 32 patienets (74%). Clinical presentations included renal failure in 24 patients (56%), thrombocytopenia, anemia, or both in 22 patients (51%), and renal mass in 21 patients (49%). Neonatal interventions included anti-coagulants in 28 patients (65%), antihypertensive medications in 9 patients (21%), peritoneal dialysis in 2 patients (5%), and nephrectomy in 2 patients (5%). The median age at follow-up was 3.7 years (range, 0.5-20.2 years). Thirteen patients (34%) had hypertension, and 11 patients (29%) had renal failure. End-stage renal disease developed in 3 patients, and they underwent live-related renal transplants. Twelve of the 28 patients (43%) examined had prothrombotic abnormalities.
Neonatal RVT is associated with significant renal morbidity and a high prevalence of prothrombotic abnormalities.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15973324</pmid><doi>10.1016/j.jpeds.2005.02.022</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 2005-06, Vol.146 (6), p.811-816 |
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| subjects | Adolescent Adult Anemia, Neonatal - etiology Anticoagulants - therapeutic use Antihypertensive Agents - therapeutic use Atrophy Biological and medical sciences Blood and lymphatic vessels Blood Coagulation Disorders, Inherited - epidemiology Canada - epidemiology Cardiology. Vascular system Child Child, Preschool Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Follow-Up Studies General aspects Humans Infant Infant, Newborn Kidney - pathology Kidney Transplantation Male Medical sciences Nephrectomy Peritoneal Dialysis Prevalence Prospective Studies Renal Insufficiency - etiology Renal Insufficiency - surgery Renal Veins Retrospective Studies Thrombocytopenia - etiology Venous Thrombosis - diagnosis Venous Thrombosis - epidemiology Venous Thrombosis - therapy |
| title | Neonatal Renal Venous Thrombosis: Clinical Outcomes and Prevalence of Prothrombotic Disorders |
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