Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody

Background: N‐glycosylation occurs in the variable region of about 10% of antibodies but the role of carbohydrate at this location is still poorly understood. Objectives: We investigated the function of N‐glycosylation in the variable region of the heavy chain of a human monoclonal antibody, mAb‐LE2...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of thrombosis and haemostasis 2006-05, Vol.4 (5), p.1047-1055
Hauptverfasser:	JACQUEMIN, M., RADCLIFFE, C. M., LAVEND'HOMME, R., WORMALD, M. R., VANDERELST, L., WALLAYS, G., DEWAELE, J., COLLEN, D., VERMYLEN, J., DWEK, R. A., SAINT‐REMY, J‐M, RUDD, P. M., DEWERCHIN, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Anticoagulants - chemistry Anticoagulants - immunology Anticoagulants - pharmacology Base Sequence CHO Cells Chromatography, Gel coagulation Cricetinae DNA Primers Factor VIII - immunology Glycosylation Humans N‐glycosylation Surface Plasmon Resonance
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!