Pulmonary Function, Cognitive Impairment and Brain Atrophy in a Middle-Aged Community Sample
Objective: To determine the relationship of lung function to brain anatomical parameters and cognitive function and to examine the mediating factors for any relationships. Methods: A random sub-sample of 469 persons (men = 252) aged 60–64 years from a larger community sample underwent brain magnetic...
Gespeichert in:
Veröffentlicht in: | Dementia and geriatric cognitive disorders 2006-01, Vol.21 (5-6), p.300-308 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 308 |
---|---|
container_issue | 5-6 |
container_start_page | 300 |
container_title | Dementia and geriatric cognitive disorders |
container_volume | 21 |
creator | Sachdev, P.S. Anstey, K.J. Parslow, R.A. Wen, W. Maller, J. Kumar, R. Christensen, H. Jorm, A.F. |
description | Objective: To determine the relationship of lung function to brain anatomical parameters and cognitive function and to examine the mediating factors for any relationships. Methods: A random sub-sample of 469 persons (men = 252) aged 60–64 years from a larger community sample underwent brain magnetic resonance imaging scans and pulmonary function tests (forced vital capacity, FVC, forced expiratory volume in the first second, FEV 1 ). Subjects were assessed for global cognitive function, episodic memory, working memory, information processing speed, fine motor dexterity and grip strength. The magnetic resonance imaging scans were analysed for overall brain atrophy, subcortical atrophy (ventricle-to-brain ratio, VBR), hippocampal volume, and white matter hyperintensity (WMH) volume. Results: FEV 1 had a significant negative correlation with overall brain atrophy and VBR in men. The FEV 1 /FVC ratio had a significant correlation with WMHs in both men and women. In regression models that controlled for sex, age, height, level of activity, smoking, chronic respiratory disease and education, FEV 1 and FVC were significant predictors of VBR but no other structural brain measure. Pulmonary function was also significantly related to information processing speed and fine motor dexterity. Male subjects with chronic respiratory disease had more deep WMHs. Path analyses to examine if structural measures mediated between lung function and cognition, and whether markers of inflammation and oxidative stress or cortisol mediated between lung function and brain measures were negative. Conclusions: Decreased lung function is related to poorer cognitive function and increased subcortical atrophy in mid-adult life. Presence of chronic respiratory disease may be related to deep WMHs in men. |
doi_str_mv | 10.1159/000091438 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67960765</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67960765</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-46a4b7d2765b950c0b0cd7930e4eba2dee3b2bf43b6fbea93efc273d3e679e7c3</originalsourceid><addsrcrecordid>eNqF0c1rFTEQAPAglrbWHjwLEgSFQlezSXaTHJ8PawstCupNWPIx-0zdZNdkV3j_vbHv0YKX5jJz-M2EmUHoRU3e1XWj3pPyVM2ZfIKOa07rSknKn97lpJKEyCP0LOfbokTTqkN0VLdccknUMfrxZRnCGHXa4osl2tmP8Ryvx030s_8D-CpM2qcAccY6OvwhaR_xak7j9HOLS6rxjXdugGq1AVfqQlhK5RZ_1WEa4Dk66PWQ4XQfT9D3i4_f1pfV9edPV-vVdWV5I-aKt5ob4ahoG6MaYokh1gnFCHAwmjoAZqjpOTNtb0ArBr2lgjkGrVAgLDtBb3d9pzT-XiDPXfDZwjDoCOOSu8JaUro_CmlZo5JMFfj6P3g7LimWITrKKFdc8Lagsx2yacw5Qd9NyYeyyq4m3b_DdPeHKfbVvuFiArgHub9EAW_2QGerhz7paH1-cLKRjbob4eXO_dJpA-ke7L75C2hynWA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>232494746</pqid></control><display><type>article</type><title>Pulmonary Function, Cognitive Impairment and Brain Atrophy in a Middle-Aged Community Sample</title><source>MEDLINE</source><source>Karger Journals Complete</source><creator>Sachdev, P.S. ; Anstey, K.J. ; Parslow, R.A. ; Wen, W. ; Maller, J. ; Kumar, R. ; Christensen, H. ; Jorm, A.F.</creator><creatorcontrib>Sachdev, P.S. ; Anstey, K.J. ; Parslow, R.A. ; Wen, W. ; Maller, J. ; Kumar, R. ; Christensen, H. ; Jorm, A.F.</creatorcontrib><description>Objective: To determine the relationship of lung function to brain anatomical parameters and cognitive function and to examine the mediating factors for any relationships. Methods: A random sub-sample of 469 persons (men = 252) aged 60–64 years from a larger community sample underwent brain magnetic resonance imaging scans and pulmonary function tests (forced vital capacity, FVC, forced expiratory volume in the first second, FEV 1 ). Subjects were assessed for global cognitive function, episodic memory, working memory, information processing speed, fine motor dexterity and grip strength. The magnetic resonance imaging scans were analysed for overall brain atrophy, subcortical atrophy (ventricle-to-brain ratio, VBR), hippocampal volume, and white matter hyperintensity (WMH) volume. Results: FEV 1 had a significant negative correlation with overall brain atrophy and VBR in men. The FEV 1 /FVC ratio had a significant correlation with WMHs in both men and women. In regression models that controlled for sex, age, height, level of activity, smoking, chronic respiratory disease and education, FEV 1 and FVC were significant predictors of VBR but no other structural brain measure. Pulmonary function was also significantly related to information processing speed and fine motor dexterity. Male subjects with chronic respiratory disease had more deep WMHs. Path analyses to examine if structural measures mediated between lung function and cognition, and whether markers of inflammation and oxidative stress or cortisol mediated between lung function and brain measures were negative. Conclusions: Decreased lung function is related to poorer cognitive function and increased subcortical atrophy in mid-adult life. Presence of chronic respiratory disease may be related to deep WMHs in men.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000091438</identifier><identifier>PMID: 16484809</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Atrophy - pathology ; Biological and medical sciences ; Brain - anatomy & histology ; Brain - pathology ; C-Reactive Protein - physiology ; Cognition Disorders - diagnosis ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cross-Sectional Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Follow-Up Studies ; Humans ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Investigative techniques, diagnostic techniques (general aspects) ; Lung Diseases - diagnosis ; Lung Diseases - epidemiology ; Lung Diseases - physiopathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Neurology ; Neuropsychological Tests ; Original Research Article ; Prevalence ; Respiratory Function Tests ; Severity of Illness Index ; Traumas. Diseases due to physical agents ; Ultrasonic investigative techniques</subject><ispartof>Dementia and geriatric cognitive disorders, 2006-01, Vol.21 (5-6), p.300-308</ispartof><rights>2006 S. Karger AG, Basel</rights><rights>2007 INIST-CNRS</rights><rights>Copyright (c) 2006 S. Karger AG, Basel.</rights><rights>Copyright (c) 2006 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-46a4b7d2765b950c0b0cd7930e4eba2dee3b2bf43b6fbea93efc273d3e679e7c3</citedby><cites>FETCH-LOGICAL-c457t-46a4b7d2765b950c0b0cd7930e4eba2dee3b2bf43b6fbea93efc273d3e679e7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18585965$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16484809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sachdev, P.S.</creatorcontrib><creatorcontrib>Anstey, K.J.</creatorcontrib><creatorcontrib>Parslow, R.A.</creatorcontrib><creatorcontrib>Wen, W.</creatorcontrib><creatorcontrib>Maller, J.</creatorcontrib><creatorcontrib>Kumar, R.</creatorcontrib><creatorcontrib>Christensen, H.</creatorcontrib><creatorcontrib>Jorm, A.F.</creatorcontrib><title>Pulmonary Function, Cognitive Impairment and Brain Atrophy in a Middle-Aged Community Sample</title><title>Dementia and geriatric cognitive disorders</title><addtitle>Dement Geriatr Cogn Disord</addtitle><description>Objective: To determine the relationship of lung function to brain anatomical parameters and cognitive function and to examine the mediating factors for any relationships. Methods: A random sub-sample of 469 persons (men = 252) aged 60–64 years from a larger community sample underwent brain magnetic resonance imaging scans and pulmonary function tests (forced vital capacity, FVC, forced expiratory volume in the first second, FEV 1 ). Subjects were assessed for global cognitive function, episodic memory, working memory, information processing speed, fine motor dexterity and grip strength. The magnetic resonance imaging scans were analysed for overall brain atrophy, subcortical atrophy (ventricle-to-brain ratio, VBR), hippocampal volume, and white matter hyperintensity (WMH) volume. Results: FEV 1 had a significant negative correlation with overall brain atrophy and VBR in men. The FEV 1 /FVC ratio had a significant correlation with WMHs in both men and women. In regression models that controlled for sex, age, height, level of activity, smoking, chronic respiratory disease and education, FEV 1 and FVC were significant predictors of VBR but no other structural brain measure. Pulmonary function was also significantly related to information processing speed and fine motor dexterity. Male subjects with chronic respiratory disease had more deep WMHs. Path analyses to examine if structural measures mediated between lung function and cognition, and whether markers of inflammation and oxidative stress or cortisol mediated between lung function and brain measures were negative. Conclusions: Decreased lung function is related to poorer cognitive function and increased subcortical atrophy in mid-adult life. Presence of chronic respiratory disease may be related to deep WMHs in men.</description><subject>Atrophy - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain - anatomy & histology</subject><subject>Brain - pathology</subject><subject>C-Reactive Protein - physiology</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>Cross-Sectional Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lung Diseases - diagnosis</subject><subject>Lung Diseases - epidemiology</subject><subject>Lung Diseases - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Original Research Article</subject><subject>Prevalence</subject><subject>Respiratory Function Tests</subject><subject>Severity of Illness Index</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Ultrasonic investigative techniques</subject><issn>1420-8008</issn><issn>1421-9824</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0c1rFTEQAPAglrbWHjwLEgSFQlezSXaTHJ8PawstCupNWPIx-0zdZNdkV3j_vbHv0YKX5jJz-M2EmUHoRU3e1XWj3pPyVM2ZfIKOa07rSknKn97lpJKEyCP0LOfbokTTqkN0VLdccknUMfrxZRnCGHXa4osl2tmP8Ryvx030s_8D-CpM2qcAccY6OvwhaR_xak7j9HOLS6rxjXdugGq1AVfqQlhK5RZ_1WEa4Dk66PWQ4XQfT9D3i4_f1pfV9edPV-vVdWV5I-aKt5ob4ahoG6MaYokh1gnFCHAwmjoAZqjpOTNtb0ArBr2lgjkGrVAgLDtBb3d9pzT-XiDPXfDZwjDoCOOSu8JaUro_CmlZo5JMFfj6P3g7LimWITrKKFdc8Lagsx2yacw5Qd9NyYeyyq4m3b_DdPeHKfbVvuFiArgHub9EAW_2QGerhz7paH1-cLKRjbob4eXO_dJpA-ke7L75C2hynWA</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Sachdev, P.S.</creator><creator>Anstey, K.J.</creator><creator>Parslow, R.A.</creator><creator>Wen, W.</creator><creator>Maller, J.</creator><creator>Kumar, R.</creator><creator>Christensen, H.</creator><creator>Jorm, A.F.</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>88J</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M2R</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Pulmonary Function, Cognitive Impairment and Brain Atrophy in a Middle-Aged Community Sample</title><author>Sachdev, P.S. ; Anstey, K.J. ; Parslow, R.A. ; Wen, W. ; Maller, J. ; Kumar, R. ; Christensen, H. ; Jorm, A.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-46a4b7d2765b950c0b0cd7930e4eba2dee3b2bf43b6fbea93efc273d3e679e7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Atrophy - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain - anatomy & histology</topic><topic>Brain - pathology</topic><topic>C-Reactive Protein - physiology</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>Cross-Sectional Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lung Diseases - diagnosis</topic><topic>Lung Diseases - epidemiology</topic><topic>Lung Diseases - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Original Research Article</topic><topic>Prevalence</topic><topic>Respiratory Function Tests</topic><topic>Severity of Illness Index</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Ultrasonic investigative techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sachdev, P.S.</creatorcontrib><creatorcontrib>Anstey, K.J.</creatorcontrib><creatorcontrib>Parslow, R.A.</creatorcontrib><creatorcontrib>Wen, W.</creatorcontrib><creatorcontrib>Maller, J.</creatorcontrib><creatorcontrib>Kumar, R.</creatorcontrib><creatorcontrib>Christensen, H.</creatorcontrib><creatorcontrib>Jorm, A.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Dementia and geriatric cognitive disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sachdev, P.S.</au><au>Anstey, K.J.</au><au>Parslow, R.A.</au><au>Wen, W.</au><au>Maller, J.</au><au>Kumar, R.</au><au>Christensen, H.</au><au>Jorm, A.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary Function, Cognitive Impairment and Brain Atrophy in a Middle-Aged Community Sample</atitle><jtitle>Dementia and geriatric cognitive disorders</jtitle><addtitle>Dement Geriatr Cogn Disord</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>21</volume><issue>5-6</issue><spage>300</spage><epage>308</epage><pages>300-308</pages><issn>1420-8008</issn><eissn>1421-9824</eissn><coden>DGCDFX</coden><abstract>Objective: To determine the relationship of lung function to brain anatomical parameters and cognitive function and to examine the mediating factors for any relationships. Methods: A random sub-sample of 469 persons (men = 252) aged 60–64 years from a larger community sample underwent brain magnetic resonance imaging scans and pulmonary function tests (forced vital capacity, FVC, forced expiratory volume in the first second, FEV 1 ). Subjects were assessed for global cognitive function, episodic memory, working memory, information processing speed, fine motor dexterity and grip strength. The magnetic resonance imaging scans were analysed for overall brain atrophy, subcortical atrophy (ventricle-to-brain ratio, VBR), hippocampal volume, and white matter hyperintensity (WMH) volume. Results: FEV 1 had a significant negative correlation with overall brain atrophy and VBR in men. The FEV 1 /FVC ratio had a significant correlation with WMHs in both men and women. In regression models that controlled for sex, age, height, level of activity, smoking, chronic respiratory disease and education, FEV 1 and FVC were significant predictors of VBR but no other structural brain measure. Pulmonary function was also significantly related to information processing speed and fine motor dexterity. Male subjects with chronic respiratory disease had more deep WMHs. Path analyses to examine if structural measures mediated between lung function and cognition, and whether markers of inflammation and oxidative stress or cortisol mediated between lung function and brain measures were negative. Conclusions: Decreased lung function is related to poorer cognitive function and increased subcortical atrophy in mid-adult life. Presence of chronic respiratory disease may be related to deep WMHs in men.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>16484809</pmid><doi>10.1159/000091438</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1420-8008 |
ispartof | Dementia and geriatric cognitive disorders, 2006-01, Vol.21 (5-6), p.300-308 |
issn | 1420-8008 1421-9824 |
language | eng |
recordid | cdi_proquest_miscellaneous_67960765 |
source | MEDLINE; Karger Journals Complete |
subjects | Atrophy - pathology Biological and medical sciences Brain - anatomy & histology Brain - pathology C-Reactive Protein - physiology Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - etiology Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Follow-Up Studies Humans Injuries of the nervous system and the skull. Diseases due to physical agents Investigative techniques, diagnostic techniques (general aspects) Lung Diseases - diagnosis Lung Diseases - epidemiology Lung Diseases - physiopathology Magnetic Resonance Imaging Male Medical sciences Middle Aged Nervous system Neurology Neuropsychological Tests Original Research Article Prevalence Respiratory Function Tests Severity of Illness Index Traumas. Diseases due to physical agents Ultrasonic investigative techniques |
title | Pulmonary Function, Cognitive Impairment and Brain Atrophy in a Middle-Aged Community Sample |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T12%3A08%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pulmonary%20Function,%20Cognitive%20Impairment%20and%20Brain%20Atrophy%20in%20a%20Middle-Aged%20Community%20Sample&rft.jtitle=Dementia%20and%20geriatric%20cognitive%20disorders&rft.au=Sachdev,%20P.S.&rft.date=2006-01-01&rft.volume=21&rft.issue=5-6&rft.spage=300&rft.epage=308&rft.pages=300-308&rft.issn=1420-8008&rft.eissn=1421-9824&rft.coden=DGCDFX&rft_id=info:doi/10.1159/000091438&rft_dat=%3Cproquest_pubme%3E67960765%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=232494746&rft_id=info:pmid/16484809&rfr_iscdi=true |