CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa
One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expres...
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| Veröffentlicht in: | Nature immunology 2005-07, Vol.6 (7), p.698-706 |
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| creator | Laouar, Amale Haridas, Viraga Vargas, Dorothy Zhinan, Xia Chaplin, David van Lier, Rene A W Manjunath, N |
| description | One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with
Listeria monocytogenes
, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa
in situ
and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection. |
| doi_str_mv | 10.1038/ni1212 |
| format | Article |
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Listeria monocytogenes
, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa
in situ
and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni1212</identifier><identifier>PMID: 15937486</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animals ; Antigen Presentation - immunology ; Antigens, CD - immunology ; Biomedical and Life Sciences ; Biomedicine ; CD27 Ligand ; Cell Differentiation - immunology ; Flow Cytometry ; Immunohistochemistry ; Immunology ; Infectious Diseases ; Intestinal Mucosa - cytology ; Intestinal Mucosa - immunology ; Intestinal Mucosa - microbiology ; Listeria monocytogenes - immunology ; Listeriosis - immunology ; Listeriosis - pathology ; Lymphocyte Activation - immunology ; Lymphocytes ; Membrane Proteins - immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Phagocytosis - immunology ; Specific Pathogen-Free Organisms ; T-Lymphocytes - cytology ; T-Lymphocytes - immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology</subject><ispartof>Nature immunology, 2005-07, Vol.6 (7), p.698-706</ispartof><rights>Springer Nature America, Inc. 2005</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-c49b9e4d9e572dd586892657e57ef056ee05a37db446a5d36824ead092175a443</citedby><cites>FETCH-LOGICAL-c441t-c49b9e4d9e572dd586892657e57ef056ee05a37db446a5d36824ead092175a443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ni1212$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ni1212$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15937486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laouar, Amale</creatorcontrib><creatorcontrib>Haridas, Viraga</creatorcontrib><creatorcontrib>Vargas, Dorothy</creatorcontrib><creatorcontrib>Zhinan, Xia</creatorcontrib><creatorcontrib>Chaplin, David</creatorcontrib><creatorcontrib>van Lier, Rene A W</creatorcontrib><creatorcontrib>Manjunath, N</creatorcontrib><title>CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><addtitle>Nat Immunol</addtitle><description>One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with
Listeria monocytogenes
, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa
in situ
and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. 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Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laouar, Amale</au><au>Haridas, Viraga</au><au>Vargas, Dorothy</au><au>Zhinan, Xia</au><au>Chaplin, David</au><au>van Lier, Rene A W</au><au>Manjunath, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>6</volume><issue>7</issue><spage>698</spage><epage>706</epage><pages>698-706</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with
Listeria monocytogenes
, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa
in situ
and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>15937486</pmid><doi>10.1038/ni1212</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Nature; Nature Journals |
| subjects | Animals Antigen Presentation - immunology Antigens, CD - immunology Biomedical and Life Sciences Biomedicine CD27 Ligand Cell Differentiation - immunology Flow Cytometry Immunohistochemistry Immunology Infectious Diseases Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Listeria monocytogenes - immunology Listeriosis - immunology Listeriosis - pathology Lymphocyte Activation - immunology Lymphocytes Membrane Proteins - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Phagocytosis - immunology Specific Pathogen-Free Organisms T-Lymphocytes - cytology T-Lymphocytes - immunology Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology |
| title | CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa |
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