Study on the characteristics of pectin–ketoprofen for colon targeting in rats
Pectin–ketoprofen (PT-KP) prodrug with the potential for colon targeted delivery has been evaluated. A sensitive HPLC method was established for the determination of concentration of ketoprofen (KP) in rats. This method was also used to evaluate the colon targeting property of PT-KP. KP or PT-KP was...
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| Veröffentlicht in: | International journal of pharmaceutics 2005-07, Vol.298 (1), p.91-97 |
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| container_end_page | 97 |
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| container_title | International journal of pharmaceutics |
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| creator | Xi, Miao Miao Zhang, San Qi Wang, Xin Yi Fang, Kun Quan Gu, Yi |
| description | Pectin–ketoprofen (PT-KP) prodrug with the potential for colon targeted delivery has been evaluated. A sensitive HPLC method was established for the determination of concentration of ketoprofen (KP) in rats. This method was also used to evaluate the colon targeting property of PT-KP. KP or PT-KP was given to rats by oral administration at a dosage of 10
mg/kg. Plasma and the different parts of gastrointestinal (GI) tract were taken after 2, 4, 6, 8, 10 and 12
h of oral administration of KP or PT-KP to rats and the concentration of KP was measured by HPLC. Preliminary experiments show KP distributes mainly in stomach, proximal small intestine and distal small intestine. However, KP released from PT-KP mainly distributes in cecum and colon. Therefore, this approach suggests that PT-KP prodrug has a good colon targeting property. |
| doi_str_mv | 10.1016/j.ijpharm.2005.04.012 |
| format | Article |
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mg/kg. Plasma and the different parts of gastrointestinal (GI) tract were taken after 2, 4, 6, 8, 10 and 12
h of oral administration of KP or PT-KP to rats and the concentration of KP was measured by HPLC. Preliminary experiments show KP distributes mainly in stomach, proximal small intestine and distal small intestine. However, KP released from PT-KP mainly distributes in cecum and colon. Therefore, this approach suggests that PT-KP prodrug has a good colon targeting property.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2005.04.012</identifier><identifier>PMID: 15922525</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Colon - metabolism ; Colon targeting ; Excipients ; Female ; General pharmacology ; Ketoprofen ; Ketoprofen - administration & dosage ; Ketoprofen - pharmacokinetics ; Male ; Medical sciences ; Pectins - administration & dosage ; Pectin–ketoprofen ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Prodrug ; Prodrugs - pharmacokinetics ; Rats</subject><ispartof>International journal of pharmaceutics, 2005-07, Vol.298 (1), p.91-97</ispartof><rights>2005 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-700ac79c864f905c5b68a2e84264d08c53aa1f1755c97de959cba00488d1d0ec3</citedby><cites>FETCH-LOGICAL-c393t-700ac79c864f905c5b68a2e84264d08c53aa1f1755c97de959cba00488d1d0ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517305002255$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16926906$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15922525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xi, Miao Miao</creatorcontrib><creatorcontrib>Zhang, San Qi</creatorcontrib><creatorcontrib>Wang, Xin Yi</creatorcontrib><creatorcontrib>Fang, Kun Quan</creatorcontrib><creatorcontrib>Gu, Yi</creatorcontrib><title>Study on the characteristics of pectin–ketoprofen for colon targeting in rats</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Pectin–ketoprofen (PT-KP) prodrug with the potential for colon targeted delivery has been evaluated. A sensitive HPLC method was established for the determination of concentration of ketoprofen (KP) in rats. This method was also used to evaluate the colon targeting property of PT-KP. KP or PT-KP was given to rats by oral administration at a dosage of 10
mg/kg. Plasma and the different parts of gastrointestinal (GI) tract were taken after 2, 4, 6, 8, 10 and 12
h of oral administration of KP or PT-KP to rats and the concentration of KP was measured by HPLC. Preliminary experiments show KP distributes mainly in stomach, proximal small intestine and distal small intestine. However, KP released from PT-KP mainly distributes in cecum and colon. Therefore, this approach suggests that PT-KP prodrug has a good colon targeting property.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Colon - metabolism</subject><subject>Colon targeting</subject><subject>Excipients</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Ketoprofen</subject><subject>Ketoprofen - administration & dosage</subject><subject>Ketoprofen - pharmacokinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pectins - administration & dosage</subject><subject>Pectin–ketoprofen</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Prodrug</subject><subject>Prodrugs - pharmacokinetics</subject><subject>Rats</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2O1DAQRi0EYpqBI4C8gV1C2Y6deIXQiD9ppFkAa8tdqcy4SceN7UaaHXfghpwEtzrSLFnVot73Vekx9lJAK0CYt7s27A53Pu1bCaBb6FoQ8hHbiKFXjep685htQPVDo0WvLtiznHcAYKRQT9mF0FZKLfWG3Xwtx_Gex4WXO-JYCz0WSiGXgJnHiR8IS1j-_v7zg0o8pDjRwqeYOMb5FPLplur-loeFJ1_yc_Zk8nOmF-u8ZN8_fvh29bm5vvn05er9dYPKqtL0AB57i4PpJgsa9dYMXtLQSdONMKBW3otJ9Fqj7Uey2uLWA3TDMIoRCNUle3PurS_9PFIubh8y0jz7heIxO9Nbre1gK6jPIKaYc6LJHVLY-3TvBLiTSbdzq0l3Mumgc9Vkzb1aDxy3exofUqu6CrxeAZ_Rz1PyC4b8wBkrjQVTuXdnjqqOX4GSyxhoQRpDqm7dGMN_XvkHgAaVpQ</recordid><startdate>20050714</startdate><enddate>20050714</enddate><creator>Xi, Miao Miao</creator><creator>Zhang, San Qi</creator><creator>Wang, Xin Yi</creator><creator>Fang, Kun Quan</creator><creator>Gu, Yi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050714</creationdate><title>Study on the characteristics of pectin–ketoprofen for colon targeting in rats</title><author>Xi, Miao Miao ; Zhang, San Qi ; Wang, Xin Yi ; Fang, Kun Quan ; Gu, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-700ac79c864f905c5b68a2e84264d08c53aa1f1755c97de959cba00488d1d0ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Colon - metabolism</topic><topic>Colon targeting</topic><topic>Excipients</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Ketoprofen</topic><topic>Ketoprofen - administration & dosage</topic><topic>Ketoprofen - pharmacokinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pectins - administration & dosage</topic><topic>Pectin–ketoprofen</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Prodrug</topic><topic>Prodrugs - pharmacokinetics</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xi, Miao Miao</creatorcontrib><creatorcontrib>Zhang, San Qi</creatorcontrib><creatorcontrib>Wang, Xin Yi</creatorcontrib><creatorcontrib>Fang, Kun Quan</creatorcontrib><creatorcontrib>Gu, Yi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xi, Miao Miao</au><au>Zhang, San Qi</au><au>Wang, Xin Yi</au><au>Fang, Kun Quan</au><au>Gu, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on the characteristics of pectin–ketoprofen for colon targeting in rats</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2005-07-14</date><risdate>2005</risdate><volume>298</volume><issue>1</issue><spage>91</spage><epage>97</epage><pages>91-97</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Pectin–ketoprofen (PT-KP) prodrug with the potential for colon targeted delivery has been evaluated. A sensitive HPLC method was established for the determination of concentration of ketoprofen (KP) in rats. This method was also used to evaluate the colon targeting property of PT-KP. KP or PT-KP was given to rats by oral administration at a dosage of 10
mg/kg. Plasma and the different parts of gastrointestinal (GI) tract were taken after 2, 4, 6, 8, 10 and 12
h of oral administration of KP or PT-KP to rats and the concentration of KP was measured by HPLC. Preliminary experiments show KP distributes mainly in stomach, proximal small intestine and distal small intestine. However, KP released from PT-KP mainly distributes in cecum and colon. Therefore, this approach suggests that PT-KP prodrug has a good colon targeting property.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15922525</pmid><doi>10.1016/j.ijpharm.2005.04.012</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of pharmaceutics, 2005-07, Vol.298 (1), p.91-97 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Chromatography, High Pressure Liquid Colon - metabolism Colon targeting Excipients Female General pharmacology Ketoprofen Ketoprofen - administration & dosage Ketoprofen - pharmacokinetics Male Medical sciences Pectins - administration & dosage Pectin–ketoprofen Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Prodrug Prodrugs - pharmacokinetics Rats |
| title | Study on the characteristics of pectin–ketoprofen for colon targeting in rats |
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