What's New in Stroke? The Top 10 for 2004/05
During the past decade, stroke has emerged from the dark ages of therapeutic nihilism to the current dawn of treatment activism, fueled by an unprecedented amount of high‐quality clinical research. Here, the choices for the “Top 10” studies of 2004/05 influencing the management of patients with stro...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2006-04, Vol.54 (4), p.674-679 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Tonarelli, Silvina B. Hart, Robert G. |
| description | During the past decade, stroke has emerged from the dark ages of therapeutic nihilism to the current dawn of treatment activism, fueled by an unprecedented amount of high‐quality clinical research. Here, the choices for the “Top 10” studies of 2004/05 influencing the management of patients with stroke and threatened stroke are reviewed. Nine are randomized, clinical trials involving a total of 61,810 participants. Three studies involved intracerebral hemorrhage, an important stroke subtype in which few trials have previously been carried out. Three studies involved acute treatment of stroke, and their results emphasize that “time is brain,” and minutes count, in management of acute ischemic and hemorrhagic stroke. The 10th study was a longitudinal cohort analysis of participants with atrial fibrillation pooled from six clinical trials that validated predictive schemes to identify those who benefit most from anticoagulation. The practical management implications of these studies refine and improve care of geriatric patients with cerebrovascular disease. |
| doi_str_mv | 10.1111/j.1532-5415.2006.00666.x |
| format | Article |
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The Top 10 for 2004/05</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>During the past decade, stroke has emerged from the dark ages of therapeutic nihilism to the current dawn of treatment activism, fueled by an unprecedented amount of high‐quality clinical research. Here, the choices for the “Top 10” studies of 2004/05 influencing the management of patients with stroke and threatened stroke are reviewed. Nine are randomized, clinical trials involving a total of 61,810 participants. Three studies involved intracerebral hemorrhage, an important stroke subtype in which few trials have previously been carried out. Three studies involved acute treatment of stroke, and their results emphasize that “time is brain,” and minutes count, in management of acute ischemic and hemorrhagic stroke. The 10th study was a longitudinal cohort analysis of participants with atrial fibrillation pooled from six clinical trials that validated predictive schemes to identify those who benefit most from anticoagulation. The practical management implications of these studies refine and improve care of geriatric patients with cerebrovascular disease.</description><subject>Anticoagulants - therapeutic use</subject><subject>antithrombotic treatment</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Cerebral Hemorrhage - complications</subject><subject>Cerebral Hemorrhage - prevention & control</subject><subject>Disease management</subject><subject>Endarterectomy, Carotid</subject><subject>Factor VII - therapeutic use</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Hypertension - prevention & control</subject><subject>intracerebral hemorrhage</subject><subject>ischemic stroke</subject><subject>Longitudinal Studies</subject><subject>Medical treatment</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Stents</subject><subject>Stroke</subject><subject>Stroke - etiology</subject><subject>Stroke - prevention & control</subject><subject>Stroke - therapy</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1LwzAUhoMoOqd_QYoXemPrSdJ8gSA6dFNkgk4Eb0Kbpti5rTPZcP57UzcmeKOBkJA87zmcB6EIQ4LDOh0mmFESsxSzhADwJGzOk8UGaq0_NlELAEgsOU530K73QwBMQMpttIM5l1xK3EInz6_Z7NhHffsRVZPocebqN3seDV5tNKinoWFU1i4KPdJTYHtoq8xG3u6vzjZ6ur4adHrx3X33pnNxF5uUEx7blFoQRWkNYUQqyiALrU2hbMklKMFTkRmcF2VpeHg2IaPA5LmwQvHcMNpGR8u6U1e_z62f6XHljR2Nsomt515zoVgYUf0JYpVSloIM4OEvcFjP3SQMoQkGKihhIkByCRlXe-9sqaeuGmfuU2PQjXc91I1e3ejVjXf97V0vQvRgVX-ej23xE1yJDsDZEvioRvbz34X1bfcxXEI8XsYrP7OLdTxzb0EGFUw_97saP7xA75KAVvQLph6aYQ</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Tonarelli, Silvina B.</creator><creator>Hart, Robert G.</creator><general>Blackwell Publishing Inc</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>What's New in Stroke? 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| ispartof | Journal of the American Geriatrics Society (JAGS), 2006-04, Vol.54 (4), p.674-679 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anticoagulants - therapeutic use antithrombotic treatment atrial fibrillation Atrial Fibrillation - diagnosis Cerebral Hemorrhage - complications Cerebral Hemorrhage - prevention & control Disease management Endarterectomy, Carotid Factor VII - therapeutic use Geriatrics Humans Hypertension - prevention & control intracerebral hemorrhage ischemic stroke Longitudinal Studies Medical treatment Platelet Aggregation Inhibitors - therapeutic use Randomized Controlled Trials as Topic Stents Stroke Stroke - etiology Stroke - prevention & control Stroke - therapy Tissue Plasminogen Activator - therapeutic use |
| title | What's New in Stroke? The Top 10 for 2004/05 |
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