Absence of caspase 3 activation in neoplastic cells of nasopharyngeal carcinoma biopsies predicts rapid fatal outcome

Poor prognosis in nasopharyngeal carcinoma patients may result from resistance to the apoptosis-inducing effect of radio- and/or chemotherapy. Apoptosis depends on proper activation of caspase 3, resulting in cleavage of key proteins like PARP-1. To investigate whether disruption of the apoptosis pa...

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Veröffentlicht in:	Modern pathology 2005-07, Vol.18 (7), p.877-885
Hauptverfasser:	Oudejans, Joost J, Harijadi, Ahemd, Cillessen, Saskia A G M, Busson, Pierre, Tan, I Bing, Dukers, Danny F, Vos, Wim, Hariwiyanto, Bambang, Middeldorp, Jaap, Meijer, Chris J L M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - radiation effects bcl-2 Biopsy Cancer caspase Caspase 3 Caspases - metabolism Cell death Cell Line, Tumor Chemotherapy Clinical outcomes Enzyme Activation Etoposide - pharmacology Female Humans Immunohistochemistry Laboratory Medicine Lymphocytes, Tumor-Infiltrating - pathology Male Medical prognosis Medicine Medicine & Public Health Metastasis Middle Aged Multivariate Analysis nasopharyngeal carcinoma Nasopharyngeal Neoplasms - enzymology Nasopharyngeal Neoplasms - mortality Nasopharyngeal Neoplasms - pathology Nasopharynx - chemistry Nasopharynx - pathology original-article Pathology prognosis Proteins Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Radiation therapy Survival Analysis Survival Rate T-Lymphocytes, Cytotoxic - pathology Tumors X-Linked Inhibitor of Apoptosis Protein XIAP
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