Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk

Patients with Barrett's esophagus (BE) are at increased risk of developing esophageal adenocarcinoma (EAC). Clinical neoplastic progression risk factors, such as age and the length of the esophageal BE segment, have been identified. However, improved molecular biomarkers predicting increased pr...

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Veröffentlicht in:	Oncogene 2005-06, Vol.24 (25), p.4138-4148
Hauptverfasser:	SCHULMANN, Karsten, STERIAN, Anca, HAMILTON, James, KAN, Takatsugu, KRASNA, Mark J, BEER, David G, PEPE, Margaret S, ABRAHAM, John M, ZIDING FENG, SCHMIEGEL, Wolff, GREENWALD, Bruce D, MELTZER, Stephen J, BERKI, Agnes, JING YIN, SATO, Fumiaki, YAN XU, OLARU, Andreea, SUNA WANG, MORI, Yuriko, DEACU, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Age Barrett Esophagus - genetics Barrett's esophagus Biological and medical sciences Biomarkers Cancer Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Core Binding Factor Alpha 3 Subunit Cyclin-Dependent Kinase Inhibitor p16 - genetics Disease Progression DNA Methylation DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification DNA-Binding Proteins - genetics Dysplasia Endoscopy Esophageal cancer Esophageal Neoplasms - genetics Esophagus Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Medicine Membrane Proteins - genetics Molecular and cellular biology mRNA Neoplasm Proteins - genetics Other diseases. Semiology Patients Polymerase Chain Reaction Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction Risk assessment Risk Factors RNA, Neoplasm - genetics RNA, Neoplasm - isolation & purification Runx3 protein Surveillance Thoracic surgery Tissue inhibitor of metalloproteinase 3 Transcription Factors - genetics Tumors
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