Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy

We have shown earlier that polyamine biosynthesis inhibition is accompanied by cell cycle alterations that can be utilized to enhance the efficacy of herpes simplex virus thymidine kinase - ganciclovir (HSV-TK/GCV) cancer gene therapy. In the present study, we asked 1) can the activated polyamine ca...

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Veröffentlicht in:	International journal of oncology 2006-06, Vol.28 (6), p.1515-1522
Hauptverfasser:	WAHLFORS, Tiina, KARPPINEN, Anne, JÄNNE, Juhani, ALHONEN, Leena, WAHLFORS, Jarmo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Biological and medical sciences Cell Cycle - drug effects Cell Line, Tumor Combined Modality Therapy Ganciclovir - therapeutic use Genetic Therapy Glioma - drug therapy Glioma - pathology Herpes simplex virus Humans Medical sciences Polyamines - metabolism Rats Simplexvirus - enzymology Thymidine Kinase - genetics Tumors
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