In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: Insights into the mechanisms of pharmacoresistance

Pharmacoresistance in epileptic patients may be ascribed to at least two, not mutually exclusive, mechanisms: a pharmacokinetic mechanism and a decreased sensitivity or availability of targets to antiepileptic drugs (AEDs; i.e., carbamazepine and phenytoin (CBZ, PHT)). Brain:plasma drug concentratio...

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Veröffentlicht in:	Brain research 2006-05, Vol.1086 (1), p.201-213
Hauptverfasser:	Oby, Emily, Caccia, Silvio, Vezzani, Annamaria, Moeddel, Gabriel, Hallene, Kerri, Guiso, Giovanna, Said, Tamer, Bingaman, William, Marchi, Nicola, Baumgartner, Christoph, Pirker, Susanne, Czech, Thomas, Lo Russo, Giorgio, Janigro, Damir
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Anticonvulsants - administration & dosage Anticonvulsants - blood Anticonvulsants - cerebrospinal fluid Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain - drug effects Brain - metabolism Brain development Child Child, Preschool Chromatography, High Pressure Liquid - methods Cortical dysplasia Drug Resistance Drug transport Epilepsy - drug therapy Epilepsy - physiopathology Female Humans In Vitro Techniques Infant Male Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Membrane Potentials - radiation effects Mice Middle Aged Neuropharmacology P-glycoprotein Patch-Clamp Techniques - methods Pharmacokinetic Pharmacology. Drug treatments Potassium Chloride - pharmacology Rats
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