Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A
Human herpesvirus-6A (HHV-6A) is a common pathogen whose role in CNS disorders including multiple sclerosis remains controversial. To understand how HHV-6A could influence inflammatory pathways in the CNS, we infected cultured human adult astrocytes and examined the expression of 268 cytokines, chem...
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| Veröffentlicht in: | Journal of neuroimmunology 2005-07, Vol.164 (1), p.37-47 |
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| creator | Meeuwsen, Sonja Persoon-Deen, Carla Bsibsi, Malika Bajramovic, Jeffrey J. Ravid, Rivka De Bolle, Leen van Noort, Johannes M. |
| description | Human herpesvirus-6A (HHV-6A) is a common pathogen whose role in CNS disorders including multiple sclerosis remains controversial. To understand how HHV-6A could influence inflammatory pathways in the CNS, we infected cultured human adult astrocytes and examined the expression of 268 cytokines, chemokines, growth factors and their receptors by gene profiling.
HHV-6 infection alone had little effect on the astrocyte gene profile but strongly altered the astrocyte response to proinflammatory cytokines. Under those conditions astrocytes express higher levels of anti-inflammatory mediators including IL-10 and IL-11, chemotactic factors, growth factors and factors controlling type I interferon production. Our data suggest that HHV-6 itself does not evoke a pro-inflammatory response in astrocytes but rather triggers immune modulatory factors in the face of inflammation. |
| doi_str_mv | 10.1016/j.jneuroim.2005.03.013 |
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HHV-6 infection alone had little effect on the astrocyte gene profile but strongly altered the astrocyte response to proinflammatory cytokines. Under those conditions astrocytes express higher levels of anti-inflammatory mediators including IL-10 and IL-11, chemotactic factors, growth factors and factors controlling type I interferon production. Our data suggest that HHV-6 itself does not evoke a pro-inflammatory response in astrocytes but rather triggers immune modulatory factors in the face of inflammation.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2005.03.013</identifier><identifier>PMID: 15904975</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Astrocytes ; Astrocytes - metabolism ; Astrocytes - virology ; Brain - cytology ; Cells, Cultured ; Cytokines ; Cytokines - genetics ; Cytokines - metabolism ; Gene Expression Profiling - methods ; Gene Expression Regulation - physiology ; Gene profiling ; Glial Fibrillary Acidic Protein - metabolism ; Growth Substances - genetics ; Growth Substances - metabolism ; Herpesvirus 6, Human - physiology ; HHV-6 ; Human herpesvirus 6 ; Humans ; Indoles ; Inflammation ; Models, Biological ; Receptors, Cytokine - genetics ; Receptors, Cytokine - metabolism ; Receptors, Growth Factor - genetics ; Receptors, Growth Factor - metabolism ; Regression Analysis ; T-Lymphocytes - metabolism ; T-Lymphocytes - virology</subject><ispartof>Journal of neuroimmunology, 2005-07, Vol.164 (1), p.37-47</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-8850a437ed285453cb62d1eea7a495cab94dab8fd72c8d0c2164e0cb452a96213</citedby><cites>FETCH-LOGICAL-c428t-8850a437ed285453cb62d1eea7a495cab94dab8fd72c8d0c2164e0cb452a96213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2005.03.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15904975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meeuwsen, Sonja</creatorcontrib><creatorcontrib>Persoon-Deen, Carla</creatorcontrib><creatorcontrib>Bsibsi, Malika</creatorcontrib><creatorcontrib>Bajramovic, Jeffrey J.</creatorcontrib><creatorcontrib>Ravid, Rivka</creatorcontrib><creatorcontrib>De Bolle, Leen</creatorcontrib><creatorcontrib>van Noort, Johannes M.</creatorcontrib><title>Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Human herpesvirus-6A (HHV-6A) is a common pathogen whose role in CNS disorders including multiple sclerosis remains controversial. To understand how HHV-6A could influence inflammatory pathways in the CNS, we infected cultured human adult astrocytes and examined the expression of 268 cytokines, chemokines, growth factors and their receptors by gene profiling.
HHV-6 infection alone had little effect on the astrocyte gene profile but strongly altered the astrocyte response to proinflammatory cytokines. Under those conditions astrocytes express higher levels of anti-inflammatory mediators including IL-10 and IL-11, chemotactic factors, growth factors and factors controlling type I interferon production. Our data suggest that HHV-6 itself does not evoke a pro-inflammatory response in astrocytes but rather triggers immune modulatory factors in the face of inflammation.</description><subject>Astrocytes</subject><subject>Astrocytes - metabolism</subject><subject>Astrocytes - virology</subject><subject>Brain - cytology</subject><subject>Cells, Cultured</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation - physiology</subject><subject>Gene profiling</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Growth Substances - genetics</subject><subject>Growth Substances - metabolism</subject><subject>Herpesvirus 6, Human - physiology</subject><subject>HHV-6</subject><subject>Human herpesvirus 6</subject><subject>Humans</subject><subject>Indoles</subject><subject>Inflammation</subject><subject>Models, Biological</subject><subject>Receptors, Cytokine - genetics</subject><subject>Receptors, Cytokine - metabolism</subject><subject>Receptors, Growth Factor - genetics</subject><subject>Receptors, Growth Factor - metabolism</subject><subject>Regression Analysis</subject><subject>T-Lymphocytes - metabolism</subject><subject>T-Lymphocytes - virology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctuGyEUgGFUpWqcyytErLqbCTBcd42i3KRE3aRrxMCxjOMZXGAS-e07kV1l6RULvsOR-BG6oqSlhMrrdbseYcopDi0jRLSkawntvqEF1Yo1mjN6ghYzFI1QTJ-is1LWhFDRcfMDnVJhCDdKLNDrSwrTxtWYRpyWuK4A-11Nb3EEPEL9SPkNxxGvpsGN2M20YldqTjOCgvvd4WYFeQvlPeapNPLmAn1fuk2By8N5jv7c373ePjbPvx-ebm-eG8-Zro3WgjjeKQhMCy4630sWKIBTjhvhXW94cL1eBsW8DsQzKjkQ33PBnJGMdufo5_7dbU5_JyjVDrF42GzcCGkqVirDjRbmKGREMSYlOwqp6jhRQsxQ7qHPqZQMS7vNcXB5Zymxn4Xs2v4vZD8LWdLZudA8eHXYMPUDhK-xQ5IZ_NoDmH_uPUK2xUcYPYSYwVcbUjy24x-ekaYo</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Meeuwsen, Sonja</creator><creator>Persoon-Deen, Carla</creator><creator>Bsibsi, Malika</creator><creator>Bajramovic, Jeffrey J.</creator><creator>Ravid, Rivka</creator><creator>De Bolle, Leen</creator><creator>van Noort, Johannes M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7U9</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A</title><author>Meeuwsen, Sonja ; Persoon-Deen, Carla ; Bsibsi, Malika ; Bajramovic, Jeffrey J. ; Ravid, Rivka ; De Bolle, Leen ; van Noort, Johannes M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-8850a437ed285453cb62d1eea7a495cab94dab8fd72c8d0c2164e0cb452a96213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Astrocytes</topic><topic>Astrocytes - metabolism</topic><topic>Astrocytes - virology</topic><topic>Brain - cytology</topic><topic>Cells, Cultured</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation - physiology</topic><topic>Gene profiling</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Growth Substances - genetics</topic><topic>Growth Substances - metabolism</topic><topic>Herpesvirus 6, Human - physiology</topic><topic>HHV-6</topic><topic>Human herpesvirus 6</topic><topic>Humans</topic><topic>Indoles</topic><topic>Inflammation</topic><topic>Models, Biological</topic><topic>Receptors, Cytokine - genetics</topic><topic>Receptors, Cytokine - metabolism</topic><topic>Receptors, Growth Factor - genetics</topic><topic>Receptors, Growth Factor - metabolism</topic><topic>Regression Analysis</topic><topic>T-Lymphocytes - metabolism</topic><topic>T-Lymphocytes - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meeuwsen, Sonja</creatorcontrib><creatorcontrib>Persoon-Deen, Carla</creatorcontrib><creatorcontrib>Bsibsi, Malika</creatorcontrib><creatorcontrib>Bajramovic, Jeffrey J.</creatorcontrib><creatorcontrib>Ravid, Rivka</creatorcontrib><creatorcontrib>De Bolle, Leen</creatorcontrib><creatorcontrib>van Noort, Johannes M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meeuwsen, Sonja</au><au>Persoon-Deen, Carla</au><au>Bsibsi, Malika</au><au>Bajramovic, Jeffrey J.</au><au>Ravid, Rivka</au><au>De Bolle, Leen</au><au>van Noort, Johannes M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>164</volume><issue>1</issue><spage>37</spage><epage>47</epage><pages>37-47</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Human herpesvirus-6A (HHV-6A) is a common pathogen whose role in CNS disorders including multiple sclerosis remains controversial. To understand how HHV-6A could influence inflammatory pathways in the CNS, we infected cultured human adult astrocytes and examined the expression of 268 cytokines, chemokines, growth factors and their receptors by gene profiling.
HHV-6 infection alone had little effect on the astrocyte gene profile but strongly altered the astrocyte response to proinflammatory cytokines. Under those conditions astrocytes express higher levels of anti-inflammatory mediators including IL-10 and IL-11, chemotactic factors, growth factors and factors controlling type I interferon production. Our data suggest that HHV-6 itself does not evoke a pro-inflammatory response in astrocytes but rather triggers immune modulatory factors in the face of inflammation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15904975</pmid><doi>10.1016/j.jneuroim.2005.03.013</doi><tpages>11</tpages></addata></record> |
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| subjects | Astrocytes Astrocytes - metabolism Astrocytes - virology Brain - cytology Cells, Cultured Cytokines Cytokines - genetics Cytokines - metabolism Gene Expression Profiling - methods Gene Expression Regulation - physiology Gene profiling Glial Fibrillary Acidic Protein - metabolism Growth Substances - genetics Growth Substances - metabolism Herpesvirus 6, Human - physiology HHV-6 Human herpesvirus 6 Humans Indoles Inflammation Models, Biological Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Receptors, Growth Factor - genetics Receptors, Growth Factor - metabolism Regression Analysis T-Lymphocytes - metabolism T-Lymphocytes - virology |
| title | Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A |
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