Gene targeting with viral vectors
Genetic manipulation of cells for scientific and therapeutic goals can be achieved by both gene-addition and gene-targeting methods. Gene targeting precisely alters a gene in its natural chromosome location, providing distinct advantages over gene-addition approaches. Classic gene-targeting delivery...
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| Veröffentlicht in: | Molecular therapy 2005-07, Vol.12 (1), p.9-17 |
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| container_title | Molecular therapy |
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| creator | Hendrie, Paul C Russell, David W |
| description | Genetic manipulation of cells for scientific and therapeutic goals can be achieved by both gene-addition and gene-targeting methods. Gene targeting precisely alters a gene in its natural chromosome location, providing distinct advantages over gene-addition approaches. Classic gene-targeting delivery systems (microinjection, electroporation, or calcium phosphate transfection) have led to major scientific advances, but are too inefficient in their current state to be used for some applications, including gene therapy. This review describes the development of gene-targeting vectors based on three types of viruses (retrovirus, adenovirus, and adeno-associated virus) and discusses the design, possible mechanisms of action, and applications of gene-targeting vectors based on adeno-associated virus. |
| doi_str_mv | 10.1016/j.ymthe.2005.04.006 |
| format | Article |
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| ispartof | Molecular therapy, 2005-07, Vol.12 (1), p.9-17 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenoviridae Adenoviruses Dependovirus Gene Targeting Gene therapy Genetic engineering Genetic Vectors Plasmids Retroviridae Streptococcus infections Vectors (Biology) Viruses |
| title | Gene targeting with viral vectors |
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