alpha-Galactosylceramide, a ligand of natural killer T cells, inhibits allergic airway inflammation

alpha-Galactosylceramide (alpha-GalCer) is a specific ligand of natural killer T cells (NKT cells) that regulates the immune responses such as tumor rejection and autoimmunity by producing interferon (IFN)-gamma and interleukin (IL)-4. However, it has not been determined whether alpha-GalCer-activat...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2005-07, Vol.33 (1), p.22-31
Hauptverfasser:	Matsuda, Hiroyuki, Suda, Takafumi, Sato, Jun, Nagata, Toshi, Koide, Yukio, Chida, Kingo, Nakamura, Hirotoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - chemistry Asthma - pathology Bronchoalveolar Lavage Fluid Cytotoxicity, Immunologic - immunology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Galactosylceramides - physiology Goblet Cells - pathology Hyperplasia Hypersensitivity Immunoglobulin E - metabolism Immunoglobulin G - immunology Inflammation Interferon-gamma - genetics Interferon-gamma - metabolism Killer Cells, Natural - cytology Ligands Lung - pathology Mice Mice, Inbred BALB C Mice, Knockout Ovalbumin - metabolism T-Lymphocytes - cytology Th2 Cells Time Factors
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