Single-Nucleotide Polymorphisms Associated with Symptomatic Infection and Differential Human Gene Expression in Healthy Seropositive Persons Each Implicate the Cytoskeleton, Integrin Signaling, and Oncosuppression in the Pathogenesis of Human Parvovirus B19 Infection
This study was undertaken to further examine the role of the host response to parvovirus B19 in the development of symptoms and consequences of viral persistence. Genomic DNA from 42 patients with symptomatic B19 infection was analyzed using the HuSNP assay (Affymetrix), and the results were compare...
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| Veröffentlicht in: | The Journal of infectious diseases 2005-07, Vol.192 (2), p.276-286 |
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| creator | Kerr, Jonathan R. Kaushik, Narendra Fear, David Baldwin, Don A. Nuwaysir, Emile F. Adcock, Ian M. |
| description | This study was undertaken to further examine the role of the host response to parvovirus B19 in the development of symptoms and consequences of viral persistence. Genomic DNA from 42 patients with symptomatic B19 infection was analyzed using the HuSNP assay (Affymetrix), and the results were compared with those from analysis of 53 healthy control individuals. Fifty-seven single-nucleotide polymorphisms were identified that were significantly associated with symptomatic infection. Total RNA from peripheral blood mononuclear cells from 57 B19-seropositive and 13 B19-seronegative donors was analyzed by hybridization to a single-color microarray representing 9522 human genes. Ninety-two genes were shown to be differentially expressed. Differential expression was confirmed in 6 of 38 genes (SKIP, MACF1, SPAG7, FLOT1, c6orf48 and RASSF5) tested using real-time quantitative polymerase chain reaction in a different group of healthy subjects. Genes identified in both studies play a functional role in the cytoskeleton, integrin signaling, and oncosuppression, themes that have been shown to be important in parvovirus infections |
| doi_str_mv | 10.1086/430950 |
| format | Article |
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Genomic DNA from 42 patients with symptomatic B19 infection was analyzed using the HuSNP assay (Affymetrix), and the results were compared with those from analysis of 53 healthy control individuals. Fifty-seven single-nucleotide polymorphisms were identified that were significantly associated with symptomatic infection. Total RNA from peripheral blood mononuclear cells from 57 B19-seropositive and 13 B19-seronegative donors was analyzed by hybridization to a single-color microarray representing 9522 human genes. Ninety-two genes were shown to be differentially expressed. Differential expression was confirmed in 6 of 38 genes (SKIP, MACF1, SPAG7, FLOT1, c6orf48 and RASSF5) tested using real-time quantitative polymerase chain reaction in a different group of healthy subjects. Genes identified in both studies play a functional role in the cytoskeleton, integrin signaling, and oncosuppression, themes that have been shown to be important in parvovirus infections</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/430950</identifier><identifier>PMID: 15962222</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Arthritis ; Biological and medical sciences ; Child ; Child, Preschool ; Cytoskeleton ; Cytoskeleton - virology ; Exanthema ; Fatigue ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Regulation, Viral ; Genetic Predisposition to Disease ; Human parvovirus B19 ; Humans ; Infant ; Infections ; Infectious diseases ; Integrins ; Integrins - physiology ; Introns ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Parvoviridae Infections - genetics ; Parvovirus ; Parvovirus - immunology ; Parvovirus - pathogenicity ; Polymerase chain reaction ; Polymorphism, Single Nucleotide ; Reference Values ; Signal Transduction - immunology ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2005-07, Vol.192 (2), p.276-286</ispartof><rights>Copyright 2005 Infectious Diseases Society of America</rights><rights>2005 by the Infectious Diseases Society of America 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright University of Chicago Press Jul 15, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-49d78dd18573d7eb5f500e60b9e9d794b8eaf70e05edf41f79d1d24c20504aa83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30086207$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30086207$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17021399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15962222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kerr, Jonathan R.</creatorcontrib><creatorcontrib>Kaushik, Narendra</creatorcontrib><creatorcontrib>Fear, David</creatorcontrib><creatorcontrib>Baldwin, Don A.</creatorcontrib><creatorcontrib>Nuwaysir, Emile F.</creatorcontrib><creatorcontrib>Adcock, Ian M.</creatorcontrib><title>Single-Nucleotide Polymorphisms Associated with Symptomatic Infection and Differential Human Gene Expression in Healthy Seropositive Persons Each Implicate the Cytoskeleton, Integrin Signaling, and Oncosuppression in the Pathogenesis of Human Parvovirus B19 Infection</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>This study was undertaken to further examine the role of the host response to parvovirus B19 in the development of symptoms and consequences of viral persistence. Genomic DNA from 42 patients with symptomatic B19 infection was analyzed using the HuSNP assay (Affymetrix), and the results were compared with those from analysis of 53 healthy control individuals. Fifty-seven single-nucleotide polymorphisms were identified that were significantly associated with symptomatic infection. Total RNA from peripheral blood mononuclear cells from 57 B19-seropositive and 13 B19-seronegative donors was analyzed by hybridization to a single-color microarray representing 9522 human genes. Ninety-two genes were shown to be differentially expressed. Differential expression was confirmed in 6 of 38 genes (SKIP, MACF1, SPAG7, FLOT1, c6orf48 and RASSF5) tested using real-time quantitative polymerase chain reaction in a different group of healthy subjects. Genes identified in both studies play a functional role in the cytoskeleton, integrin signaling, and oncosuppression, themes that have been shown to be important in parvovirus infections</description><subject>Adolescent</subject><subject>Adult</subject><subject>Arthritis</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytoskeleton</subject><subject>Cytoskeleton - virology</subject><subject>Exanthema</subject><subject>Fatigue</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Viral</subject><subject>Genetic Predisposition to Disease</subject><subject>Human parvovirus B19</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Integrins</subject><subject>Integrins - physiology</subject><subject>Introns</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Parvoviridae Infections - genetics</subject><subject>Parvovirus</subject><subject>Parvovirus - immunology</subject><subject>Parvovirus - pathogenicity</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Reference Values</subject><subject>Signal Transduction - immunology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl9v0zAUxQMCsVLgG4A8JHhawM7_PI5S2qKKVS0ItJfIdW5ad4kdfJ2yfntcWq0TEsIvfjg_n3N8dT3vBaPvGM2S91FI85g-9HosDlM_SVj4yOtRGgQ-y_L8zHuKuKGURmGSPvHOWJwngTu9B_2FVKsa_C-dqEFbWQKZ6XrXaNOuJTZILhG1kNxCSX5JuyaLXdNa3XArBZmoCoSVWhGuSvJRVhUYUFbymoy7hisyAgVkeNsaQNxjUpEx8Nqud2QBRrcapZVbFwkGtUIy5GJNJk1bS-ESiV0DGeysxhuowWp14RItrIyzWciV4rXrfvEn-0oJjV17P2j_eMbtWq9cCZRIdHVsNeNmq7fSdEg-sPz0i2fe44rXCM-Pd9_79mn4dTD2p1ejyeBy6osoC60f5WWalSXL4jQsU1jGVUwpJHSZg1PyaJkBr1IKNIayiliV5iUrg0gENKYR51nY994efFujf3aAtmgkCqhrrkB3WCTOJAvz_L8gS2PKgiR24Ou_wI3ujBsQFkEQ5jSi0T03YTSigapojWy42RWMFvslKg5L5MBXR7du2UB5wo5b44A3R4Cj4HVluBIST1xKA3bof37gdNf-O-zlgdmg1eaOCqljApo63T_oEi3c3unc3Lg5hWlcjH9cF_P559H0OvlezMPfiT_2kQ</recordid><startdate>20050715</startdate><enddate>20050715</enddate><creator>Kerr, Jonathan R.</creator><creator>Kaushik, Narendra</creator><creator>Fear, David</creator><creator>Baldwin, Don A.</creator><creator>Nuwaysir, Emile F.</creator><creator>Adcock, Ian M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050715</creationdate><title>Single-Nucleotide Polymorphisms Associated with Symptomatic Infection and Differential Human Gene Expression in Healthy Seropositive Persons Each Implicate the Cytoskeleton, Integrin Signaling, and Oncosuppression in the Pathogenesis of Human Parvovirus B19 Infection</title><author>Kerr, Jonathan R. ; Kaushik, Narendra ; Fear, David ; Baldwin, Don A. ; Nuwaysir, Emile F. ; Adcock, Ian M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-49d78dd18573d7eb5f500e60b9e9d794b8eaf70e05edf41f79d1d24c20504aa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Arthritis</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytoskeleton</topic><topic>Cytoskeleton - virology</topic><topic>Exanthema</topic><topic>Fatigue</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Viral</topic><topic>Genetic Predisposition to Disease</topic><topic>Human parvovirus B19</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Integrins</topic><topic>Integrins - physiology</topic><topic>Introns</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Parvoviridae Infections - genetics</topic><topic>Parvovirus</topic><topic>Parvovirus - immunology</topic><topic>Parvovirus - pathogenicity</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Reference Values</topic><topic>Signal Transduction - immunology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kerr, Jonathan R.</creatorcontrib><creatorcontrib>Kaushik, Narendra</creatorcontrib><creatorcontrib>Fear, David</creatorcontrib><creatorcontrib>Baldwin, Don A.</creatorcontrib><creatorcontrib>Nuwaysir, Emile F.</creatorcontrib><creatorcontrib>Adcock, Ian M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerr, Jonathan R.</au><au>Kaushik, Narendra</au><au>Fear, David</au><au>Baldwin, Don A.</au><au>Nuwaysir, Emile F.</au><au>Adcock, Ian M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-Nucleotide Polymorphisms Associated with Symptomatic Infection and Differential Human Gene Expression in Healthy Seropositive Persons Each Implicate the Cytoskeleton, Integrin Signaling, and Oncosuppression in the Pathogenesis of Human Parvovirus B19 Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2005-07-15</date><risdate>2005</risdate><volume>192</volume><issue>2</issue><spage>276</spage><epage>286</epage><pages>276-286</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>This study was undertaken to further examine the role of the host response to parvovirus B19 in the development of symptoms and consequences of viral persistence. Genomic DNA from 42 patients with symptomatic B19 infection was analyzed using the HuSNP assay (Affymetrix), and the results were compared with those from analysis of 53 healthy control individuals. Fifty-seven single-nucleotide polymorphisms were identified that were significantly associated with symptomatic infection. Total RNA from peripheral blood mononuclear cells from 57 B19-seropositive and 13 B19-seronegative donors was analyzed by hybridization to a single-color microarray representing 9522 human genes. Ninety-two genes were shown to be differentially expressed. Differential expression was confirmed in 6 of 38 genes (SKIP, MACF1, SPAG7, FLOT1, c6orf48 and RASSF5) tested using real-time quantitative polymerase chain reaction in a different group of healthy subjects. Genes identified in both studies play a functional role in the cytoskeleton, integrin signaling, and oncosuppression, themes that have been shown to be important in parvovirus infections</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15962222</pmid><doi>10.1086/430950</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adolescent Adult Arthritis Biological and medical sciences Child Child, Preschool Cytoskeleton Cytoskeleton - virology Exanthema Fatigue Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Viral Genetic Predisposition to Disease Human parvovirus B19 Humans Infant Infections Infectious diseases Integrins Integrins - physiology Introns Male Medical sciences Microbiology Middle Aged Miscellaneous Parvoviridae Infections - genetics Parvovirus Parvovirus - immunology Parvovirus - pathogenicity Polymerase chain reaction Polymorphism, Single Nucleotide Reference Values Signal Transduction - immunology Virology Viruses |
| title | Single-Nucleotide Polymorphisms Associated with Symptomatic Infection and Differential Human Gene Expression in Healthy Seropositive Persons Each Implicate the Cytoskeleton, Integrin Signaling, and Oncosuppression in the Pathogenesis of Human Parvovirus B19 Infection |
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