Umbilical Cord Blood-Derived Stem Cells and Brain Repair
: Human umbilical cord blood (HUCB) is now considered a valuable source for stem cell‐based therapies. HUCB cells are enriched for stem cells that have the potential to initiate and maintain tissue repair. This potential is especially attractive in neural diseases for which no current cure is availa...
Gespeichert in:
| Veröffentlicht in: | Annals of the New York Academy of Sciences 2005-05, Vol.1049 (1), p.67-83 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 83 |
|---|---|
| container_issue | 1 |
| container_start_page | 67 |
| container_title | Annals of the New York Academy of Sciences |
| container_volume | 1049 |
| creator | SANBERG, PAUL R. WILLING, ALISON E. GARBUZOVA-DAVIS, SVITLANA SAPORTA, SAMUEL LIU, GUOQING SANBERG, CYNDY DAVIS BICKFORD, PAULA C. KLASKO, STEPHEN K. EL-BADRI, NAGWA S. |
| description | : Human umbilical cord blood (HUCB) is now considered a valuable source for stem cell‐based therapies. HUCB cells are enriched for stem cells that have the potential to initiate and maintain tissue repair. This potential is especially attractive in neural diseases for which no current cure is available. Furthermore, HUCB cells are easily available and less immunogenic compared to other sources for stem cell therapy such as bone marrow. Accordingly, the number of cord blood transplants has doubled in the last year alone, especially in the pediatric population. The therapeutic potential of HUCB cells may be attributed to inherent ability of stem cell populations to replace damaged tissues. Alternatively, various cell types within the graft may promote neural repair by delivering neural protection and secretion of neurotrophic factors. In this review, we evaluate the preclinical studies in which HUCB was applied for treatment of neurodegenerative diseases and for traumatic and ischemic brain damage. We discuss how transplantation of HUCB cells affects these disorders and we present recent clinical studies with promising outcome. |
| doi_str_mv | 10.1196/annals.1334.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67948388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17361017</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5817-384dc06f411670428e8f75dcbf328879af56fb5cfb1d9bf115ece91955e046df3</originalsourceid><addsrcrecordid>eNqFkUtPGzEURq2qqAlp191Vs6q6mcR3_F6GlJd4VIIixMryzNiSyzyCnQD59ziaiO7Ixl74fJ-vfRD6DngKoPjMdJ1p4hQIoVOM5Sc0BkFVzjkpPqMxxkLkUhVkhA5j_IcxFJKKL2gETHEGWI6RvGtL3_jKNNmiD3V21PR9nf-2wT_bOrtd2TZb2KaJmenSYTC-y27s0vjwFR24dLX9ttsn6O7k-O_iLL_8c3q-mF_mFZMgciJpXWHuKAAXmBbSSidYXZWOFFIKZRzjrmSVK6FWpQNgtrIKFGMWU147MkE_h95l6J_WNq5062OVRjKd7ddRc6GoJFLuBUEQDjitE_TrY5ALobjkAvajDAilBVc8obMBrUIfY7BOL4NvTdhowHrrSg-u9NaVTq5S4seufF22tv7P7-QkgAzAi2_sZl-fvn6Y3_Lt8_Ih5ePKvr6nTHhMf0UE0_fXp1opqW6UutIX5A2Mya0z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1513442696</pqid></control><display><type>article</type><title>Umbilical Cord Blood-Derived Stem Cells and Brain Repair</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>SANBERG, PAUL R. ; WILLING, ALISON E. ; GARBUZOVA-DAVIS, SVITLANA ; SAPORTA, SAMUEL ; LIU, GUOQING ; SANBERG, CYNDY DAVIS ; BICKFORD, PAULA C. ; KLASKO, STEPHEN K. ; EL-BADRI, NAGWA S.</creator><creatorcontrib>SANBERG, PAUL R. ; WILLING, ALISON E. ; GARBUZOVA-DAVIS, SVITLANA ; SAPORTA, SAMUEL ; LIU, GUOQING ; SANBERG, CYNDY DAVIS ; BICKFORD, PAULA C. ; KLASKO, STEPHEN K. ; EL-BADRI, NAGWA S.</creatorcontrib><description>: Human umbilical cord blood (HUCB) is now considered a valuable source for stem cell‐based therapies. HUCB cells are enriched for stem cells that have the potential to initiate and maintain tissue repair. This potential is especially attractive in neural diseases for which no current cure is available. Furthermore, HUCB cells are easily available and less immunogenic compared to other sources for stem cell therapy such as bone marrow. Accordingly, the number of cord blood transplants has doubled in the last year alone, especially in the pediatric population. The therapeutic potential of HUCB cells may be attributed to inherent ability of stem cell populations to replace damaged tissues. Alternatively, various cell types within the graft may promote neural repair by delivering neural protection and secretion of neurotrophic factors. In this review, we evaluate the preclinical studies in which HUCB was applied for treatment of neurodegenerative diseases and for traumatic and ischemic brain damage. We discuss how transplantation of HUCB cells affects these disorders and we present recent clinical studies with promising outcome.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1334.008</identifier><identifier>PMID: 15965108</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Blood ; Brain Injuries - pathology ; Brain Injuries - therapy ; Brain Ischemia - therapy ; brain repair ; Cell Differentiation ; Clinical Trials as Topic ; cord blood ; Cord Blood Stem Cell Transplantation ; Diseases ; Fetal Blood - cytology ; Humans ; Medical services ; Neurodegenerative Diseases - pathology ; Neurodegenerative Diseases - therapy ; neurogenesis ; Repair ; Secretions ; stem cell ; Stem cells ; Stem Cells - cytology ; Stem Cells - metabolism ; Therapy ; Transplantation, Heterologous ; Umbilical cords</subject><ispartof>Annals of the New York Academy of Sciences, 2005-05, Vol.1049 (1), p.67-83</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5817-384dc06f411670428e8f75dcbf328879af56fb5cfb1d9bf115ece91955e046df3</citedby><cites>FETCH-LOGICAL-c5817-384dc06f411670428e8f75dcbf328879af56fb5cfb1d9bf115ece91955e046df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1334.008$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1334.008$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15965108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANBERG, PAUL R.</creatorcontrib><creatorcontrib>WILLING, ALISON E.</creatorcontrib><creatorcontrib>GARBUZOVA-DAVIS, SVITLANA</creatorcontrib><creatorcontrib>SAPORTA, SAMUEL</creatorcontrib><creatorcontrib>LIU, GUOQING</creatorcontrib><creatorcontrib>SANBERG, CYNDY DAVIS</creatorcontrib><creatorcontrib>BICKFORD, PAULA C.</creatorcontrib><creatorcontrib>KLASKO, STEPHEN K.</creatorcontrib><creatorcontrib>EL-BADRI, NAGWA S.</creatorcontrib><title>Umbilical Cord Blood-Derived Stem Cells and Brain Repair</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: Human umbilical cord blood (HUCB) is now considered a valuable source for stem cell‐based therapies. HUCB cells are enriched for stem cells that have the potential to initiate and maintain tissue repair. This potential is especially attractive in neural diseases for which no current cure is available. Furthermore, HUCB cells are easily available and less immunogenic compared to other sources for stem cell therapy such as bone marrow. Accordingly, the number of cord blood transplants has doubled in the last year alone, especially in the pediatric population. The therapeutic potential of HUCB cells may be attributed to inherent ability of stem cell populations to replace damaged tissues. Alternatively, various cell types within the graft may promote neural repair by delivering neural protection and secretion of neurotrophic factors. In this review, we evaluate the preclinical studies in which HUCB was applied for treatment of neurodegenerative diseases and for traumatic and ischemic brain damage. We discuss how transplantation of HUCB cells affects these disorders and we present recent clinical studies with promising outcome.</description><subject>Animals</subject><subject>Blood</subject><subject>Brain Injuries - pathology</subject><subject>Brain Injuries - therapy</subject><subject>Brain Ischemia - therapy</subject><subject>brain repair</subject><subject>Cell Differentiation</subject><subject>Clinical Trials as Topic</subject><subject>cord blood</subject><subject>Cord Blood Stem Cell Transplantation</subject><subject>Diseases</subject><subject>Fetal Blood - cytology</subject><subject>Humans</subject><subject>Medical services</subject><subject>Neurodegenerative Diseases - pathology</subject><subject>Neurodegenerative Diseases - therapy</subject><subject>neurogenesis</subject><subject>Repair</subject><subject>Secretions</subject><subject>stem cell</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Therapy</subject><subject>Transplantation, Heterologous</subject><subject>Umbilical cords</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPGzEURq2qqAlp191Vs6q6mcR3_F6GlJd4VIIixMryzNiSyzyCnQD59ziaiO7Ixl74fJ-vfRD6DngKoPjMdJ1p4hQIoVOM5Sc0BkFVzjkpPqMxxkLkUhVkhA5j_IcxFJKKL2gETHEGWI6RvGtL3_jKNNmiD3V21PR9nf-2wT_bOrtd2TZb2KaJmenSYTC-y27s0vjwFR24dLX9ttsn6O7k-O_iLL_8c3q-mF_mFZMgciJpXWHuKAAXmBbSSidYXZWOFFIKZRzjrmSVK6FWpQNgtrIKFGMWU147MkE_h95l6J_WNq5062OVRjKd7ddRc6GoJFLuBUEQDjitE_TrY5ALobjkAvajDAilBVc8obMBrUIfY7BOL4NvTdhowHrrSg-u9NaVTq5S4seufF22tv7P7-QkgAzAi2_sZl-fvn6Y3_Lt8_Ih5ePKvr6nTHhMf0UE0_fXp1opqW6UutIX5A2Mya0z</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>SANBERG, PAUL R.</creator><creator>WILLING, ALISON E.</creator><creator>GARBUZOVA-DAVIS, SVITLANA</creator><creator>SAPORTA, SAMUEL</creator><creator>LIU, GUOQING</creator><creator>SANBERG, CYNDY DAVIS</creator><creator>BICKFORD, PAULA C.</creator><creator>KLASKO, STEPHEN K.</creator><creator>EL-BADRI, NAGWA S.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200505</creationdate><title>Umbilical Cord Blood-Derived Stem Cells and Brain Repair</title><author>SANBERG, PAUL R. ; WILLING, ALISON E. ; GARBUZOVA-DAVIS, SVITLANA ; SAPORTA, SAMUEL ; LIU, GUOQING ; SANBERG, CYNDY DAVIS ; BICKFORD, PAULA C. ; KLASKO, STEPHEN K. ; EL-BADRI, NAGWA S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5817-384dc06f411670428e8f75dcbf328879af56fb5cfb1d9bf115ece91955e046df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Blood</topic><topic>Brain Injuries - pathology</topic><topic>Brain Injuries - therapy</topic><topic>Brain Ischemia - therapy</topic><topic>brain repair</topic><topic>Cell Differentiation</topic><topic>Clinical Trials as Topic</topic><topic>cord blood</topic><topic>Cord Blood Stem Cell Transplantation</topic><topic>Diseases</topic><topic>Fetal Blood - cytology</topic><topic>Humans</topic><topic>Medical services</topic><topic>Neurodegenerative Diseases - pathology</topic><topic>Neurodegenerative Diseases - therapy</topic><topic>neurogenesis</topic><topic>Repair</topic><topic>Secretions</topic><topic>stem cell</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Therapy</topic><topic>Transplantation, Heterologous</topic><topic>Umbilical cords</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANBERG, PAUL R.</creatorcontrib><creatorcontrib>WILLING, ALISON E.</creatorcontrib><creatorcontrib>GARBUZOVA-DAVIS, SVITLANA</creatorcontrib><creatorcontrib>SAPORTA, SAMUEL</creatorcontrib><creatorcontrib>LIU, GUOQING</creatorcontrib><creatorcontrib>SANBERG, CYNDY DAVIS</creatorcontrib><creatorcontrib>BICKFORD, PAULA C.</creatorcontrib><creatorcontrib>KLASKO, STEPHEN K.</creatorcontrib><creatorcontrib>EL-BADRI, NAGWA S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANBERG, PAUL R.</au><au>WILLING, ALISON E.</au><au>GARBUZOVA-DAVIS, SVITLANA</au><au>SAPORTA, SAMUEL</au><au>LIU, GUOQING</au><au>SANBERG, CYNDY DAVIS</au><au>BICKFORD, PAULA C.</au><au>KLASKO, STEPHEN K.</au><au>EL-BADRI, NAGWA S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Umbilical Cord Blood-Derived Stem Cells and Brain Repair</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2005-05</date><risdate>2005</risdate><volume>1049</volume><issue>1</issue><spage>67</spage><epage>83</epage><pages>67-83</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Human umbilical cord blood (HUCB) is now considered a valuable source for stem cell‐based therapies. HUCB cells are enriched for stem cells that have the potential to initiate and maintain tissue repair. This potential is especially attractive in neural diseases for which no current cure is available. Furthermore, HUCB cells are easily available and less immunogenic compared to other sources for stem cell therapy such as bone marrow. Accordingly, the number of cord blood transplants has doubled in the last year alone, especially in the pediatric population. The therapeutic potential of HUCB cells may be attributed to inherent ability of stem cell populations to replace damaged tissues. Alternatively, various cell types within the graft may promote neural repair by delivering neural protection and secretion of neurotrophic factors. In this review, we evaluate the preclinical studies in which HUCB was applied for treatment of neurodegenerative diseases and for traumatic and ischemic brain damage. We discuss how transplantation of HUCB cells affects these disorders and we present recent clinical studies with promising outcome.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15965108</pmid><doi>10.1196/annals.1334.008</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2005-05, Vol.1049 (1), p.67-83 |
| issn | 0077-8923 1749-6632 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67948388 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Blood Brain Injuries - pathology Brain Injuries - therapy Brain Ischemia - therapy brain repair Cell Differentiation Clinical Trials as Topic cord blood Cord Blood Stem Cell Transplantation Diseases Fetal Blood - cytology Humans Medical services Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy neurogenesis Repair Secretions stem cell Stem cells Stem Cells - cytology Stem Cells - metabolism Therapy Transplantation, Heterologous Umbilical cords |
| title | Umbilical Cord Blood-Derived Stem Cells and Brain Repair |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T21%3A45%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Umbilical%20Cord%20Blood-Derived%20Stem%20Cells%20and%20Brain%20Repair&rft.jtitle=Annals%20of%20the%20New%20York%20Academy%20of%20Sciences&rft.au=SANBERG,%20PAUL%20R.&rft.date=2005-05&rft.volume=1049&rft.issue=1&rft.spage=67&rft.epage=83&rft.pages=67-83&rft.issn=0077-8923&rft.eissn=1749-6632&rft_id=info:doi/10.1196/annals.1334.008&rft_dat=%3Cproquest_cross%3E17361017%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1513442696&rft_id=info:pmid/15965108&rfr_iscdi=true |