Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells

Recent genetic analysis has identified a pivotal role of primary cilia in the pathogenesis of polycystic kidney disease (PKD). However, little is known regarding how cilia loss/dysfunction contributes to cyst development. In epithelial cells, changes in apical fluid flow induce cilia-mediated Ca2+ e...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2006-06, Vol.290 (6), p.F1320-F1328
Hauptverfasser:	Siroky, Brian J, Ferguson, William B, Fuson, Amanda L, Xie, Yi, Fintha, Attila, Komlosi, Peter, Yoder, Bradley K, Schwiebert, Erik M, Guay-Woodford, Lisa M, Bell, P Darwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cell Membrane Permeability Cells, Cultured Cilia - pathology Cilia - physiology Fluorescent Antibody Technique Fluorescent Dyes Fura-2 - analogs & derivatives Gadolinium - pharmacology Kidney Tubules, Collecting - metabolism Kidney Tubules, Collecting - ultrastructure Manganese - metabolism Mice Polycystic Kidney, Autosomal Dominant - genetics Polycystic Kidney, Autosomal Dominant - pathology TRPP Cation Channels - antagonists & inhibitors TRPP Cation Channels - metabolism Tumor Suppressor Proteins - genetics
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