Cortical Inefficiency in Patients with Unipolar Depression: An Event-Related fMRI Study with the Stroop Task
The present study is aimed to examine the neuronal correlates of Stroop interference in medication-free patients with major depressive disorder. Sixteen patients fulfilling Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for unipolar depression and 16 healthy control subjects...
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| Veröffentlicht in: | Biological psychiatry (1969) 2006-05, Vol.59 (10), p.958-965 |
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| container_title | Biological psychiatry (1969) |
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| creator | Wagner, Gerd Sinsel, Esther Sobanski, Thomas Köhler, Sabine Marinou, Varvara Mentzel, Hans-Joachim Sauer, Heinrich Schlösser, Ralf G.M. |
| description | The present study is aimed to examine the neuronal correlates of Stroop interference in medication-free patients with major depressive disorder.
Sixteen patients fulfilling Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for unipolar depression and 16 healthy control subjects matched for age, gender, and education were included. All subjects underwent an event-related functional magnetic resonance imaging (fMRI) design with an adapted version of the Stroop task including congruent and incongruent task conditions. The fMRI experiment was conducted on a 1.5 T magnetic resonance (MR) scanner, and item responses were given manually by the subjects.
With regard to behavioral performance, patients revealed no differences in both reaction time and accuracy relative to control subjects. With regard to brain activations, direct comparison of patients with control subjects in the interference condition revealed hyperactivity in rostral anterior cingulate gyrus (rACG) and left dorsolateral prefrontal cortex (DLPFC) in depressive patients, which correlated strongly with the Stroop interference.
The study provides new evidence for the functioning and dissociation of the anterior cingulate in depressed patients. The greater prefrontal activation may reflect a cortical inefficiency due to hyperactivity in rACG enhancing the cognitive interferences from the emotional state. |
| doi_str_mv | 10.1016/j.biopsych.2005.10.025 |
| format | Article |
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Sixteen patients fulfilling Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for unipolar depression and 16 healthy control subjects matched for age, gender, and education were included. All subjects underwent an event-related functional magnetic resonance imaging (fMRI) design with an adapted version of the Stroop task including congruent and incongruent task conditions. The fMRI experiment was conducted on a 1.5 T magnetic resonance (MR) scanner, and item responses were given manually by the subjects.
With regard to behavioral performance, patients revealed no differences in both reaction time and accuracy relative to control subjects. With regard to brain activations, direct comparison of patients with control subjects in the interference condition revealed hyperactivity in rostral anterior cingulate gyrus (rACG) and left dorsolateral prefrontal cortex (DLPFC) in depressive patients, which correlated strongly with the Stroop interference.
The study provides new evidence for the functioning and dissociation of the anterior cingulate in depressed patients. The greater prefrontal activation may reflect a cortical inefficiency due to hyperactivity in rACG enhancing the cognitive interferences from the emotional state.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2005.10.025</identifier><identifier>PMID: 16458263</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; anterior cingulated ; Attention - physiology ; Biological and medical sciences ; Brain Mapping ; Cerebral Cortex - physiopathology ; cognitive inhibition ; Color Perception - physiology ; Conflict (Psychology) ; Depression ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - physiopathology ; Dominance, Cerebral - physiology ; Electroencephalography ; Evoked Potentials, Visual - physiology ; Female ; functional magnetic resonance imaging ; Gyrus Cinguli - physiopathology ; Humans ; Image Processing, Computer-Assisted ; Inhibition (Psychology) ; Magnetic Resonance Imaging ; Major depressive disorder ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Neuropsychological Tests ; prefrontal cortex ; Prefrontal Cortex - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Reading ; Reference Values ; Semantics ; Statistics as Topic ; Stroop task</subject><ispartof>Biological psychiatry (1969), 2006-05, Vol.59 (10), p.958-965</ispartof><rights>2006 Society of Biological Psychiatry</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-6b21163c29ad94eb77e1ae18a25dd69839a3628c238d83dab0185462d6c4e3ae3</citedby><cites>FETCH-LOGICAL-c311t-6b21163c29ad94eb77e1ae18a25dd69839a3628c238d83dab0185462d6c4e3ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopsych.2005.10.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17778804$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16458263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wagner, Gerd</creatorcontrib><creatorcontrib>Sinsel, Esther</creatorcontrib><creatorcontrib>Sobanski, Thomas</creatorcontrib><creatorcontrib>Köhler, Sabine</creatorcontrib><creatorcontrib>Marinou, Varvara</creatorcontrib><creatorcontrib>Mentzel, Hans-Joachim</creatorcontrib><creatorcontrib>Sauer, Heinrich</creatorcontrib><creatorcontrib>Schlösser, Ralf G.M.</creatorcontrib><title>Cortical Inefficiency in Patients with Unipolar Depression: An Event-Related fMRI Study with the Stroop Task</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>The present study is aimed to examine the neuronal correlates of Stroop interference in medication-free patients with major depressive disorder.
Sixteen patients fulfilling Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for unipolar depression and 16 healthy control subjects matched for age, gender, and education were included. All subjects underwent an event-related functional magnetic resonance imaging (fMRI) design with an adapted version of the Stroop task including congruent and incongruent task conditions. The fMRI experiment was conducted on a 1.5 T magnetic resonance (MR) scanner, and item responses were given manually by the subjects.
With regard to behavioral performance, patients revealed no differences in both reaction time and accuracy relative to control subjects. With regard to brain activations, direct comparison of patients with control subjects in the interference condition revealed hyperactivity in rostral anterior cingulate gyrus (rACG) and left dorsolateral prefrontal cortex (DLPFC) in depressive patients, which correlated strongly with the Stroop interference.
The study provides new evidence for the functioning and dissociation of the anterior cingulate in depressed patients. The greater prefrontal activation may reflect a cortical inefficiency due to hyperactivity in rACG enhancing the cognitive interferences from the emotional state.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>anterior cingulated</subject><subject>Attention - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - physiopathology</subject><subject>cognitive inhibition</subject><subject>Color Perception - physiology</subject><subject>Conflict (Psychology)</subject><subject>Depression</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Dominance, Cerebral - physiology</subject><subject>Electroencephalography</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Female</subject><subject>functional magnetic resonance imaging</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Inhibition (Psychology)</subject><subject>Magnetic Resonance Imaging</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Neuropsychological Tests</subject><subject>prefrontal cortex</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Reading</subject><subject>Reference Values</subject><subject>Semantics</subject><subject>Statistics as Topic</subject><subject>Stroop task</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vGyEQhlHVqHHT_oWIS3tbl49dYHtq5KSJpUSp0uSMWJiVcdfLFnAq__vi2lWOOTEzel5AzyB0TsmcEiq-rOedD1Pa2dWcEdKU4Zyw5g2aUSV5xWrC3qIZIURUnDF-it6ntC6tZIy-Q6dU1I1igs_QsAgxe2sGvByh7731MNod9iP-YXKpc8J_fF7hp9FPYTARX8IUISUfxq_4YsRXz4WpHmAwGRzu7x6W-Gfeut0hlVdQ2hjChB9N-vUBnfRmSPDxeJ6hp-9Xj4ub6vb-erm4uK0spzRXomOUCm5Za1xbQyclUANUGdY4J1rFW8MFU5Zx5RR3piNUNbVgTtgauAF-hj4f7p1i-L2FlPXGJwvDYEYI26SFbGupiCygOIA2hpQi9HqKfmPiTlOi9571Wv_3rPee9_PiuQTPjy9suw24l9hRbAE-HQGTit0-mtH69MJJKZUideG-HTgoPp49RJ3-rQCcj2CzdsG_9pe_TpifXA</recordid><startdate>20060515</startdate><enddate>20060515</enddate><creator>Wagner, Gerd</creator><creator>Sinsel, Esther</creator><creator>Sobanski, Thomas</creator><creator>Köhler, Sabine</creator><creator>Marinou, Varvara</creator><creator>Mentzel, Hans-Joachim</creator><creator>Sauer, Heinrich</creator><creator>Schlösser, Ralf G.M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060515</creationdate><title>Cortical Inefficiency in Patients with Unipolar Depression: An Event-Related fMRI Study with the Stroop Task</title><author>Wagner, Gerd ; Sinsel, Esther ; Sobanski, Thomas ; Köhler, Sabine ; Marinou, Varvara ; Mentzel, Hans-Joachim ; Sauer, Heinrich ; Schlösser, Ralf G.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-6b21163c29ad94eb77e1ae18a25dd69839a3628c238d83dab0185462d6c4e3ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>anterior cingulated</topic><topic>Attention - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - physiopathology</topic><topic>cognitive inhibition</topic><topic>Color Perception - physiology</topic><topic>Conflict (Psychology)</topic><topic>Depression</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Dominance, Cerebral - physiology</topic><topic>Electroencephalography</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Female</topic><topic>functional magnetic resonance imaging</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Inhibition (Psychology)</topic><topic>Magnetic Resonance Imaging</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Neuropsychological Tests</topic><topic>prefrontal cortex</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Reading</topic><topic>Reference Values</topic><topic>Semantics</topic><topic>Statistics as Topic</topic><topic>Stroop task</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wagner, Gerd</creatorcontrib><creatorcontrib>Sinsel, Esther</creatorcontrib><creatorcontrib>Sobanski, Thomas</creatorcontrib><creatorcontrib>Köhler, Sabine</creatorcontrib><creatorcontrib>Marinou, Varvara</creatorcontrib><creatorcontrib>Mentzel, Hans-Joachim</creatorcontrib><creatorcontrib>Sauer, Heinrich</creatorcontrib><creatorcontrib>Schlösser, Ralf G.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagner, Gerd</au><au>Sinsel, Esther</au><au>Sobanski, Thomas</au><au>Köhler, Sabine</au><au>Marinou, Varvara</au><au>Mentzel, Hans-Joachim</au><au>Sauer, Heinrich</au><au>Schlösser, Ralf G.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical Inefficiency in Patients with Unipolar Depression: An Event-Related fMRI Study with the Stroop Task</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2006-05-15</date><risdate>2006</risdate><volume>59</volume><issue>10</issue><spage>958</spage><epage>965</epage><pages>958-965</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>The present study is aimed to examine the neuronal correlates of Stroop interference in medication-free patients with major depressive disorder.
Sixteen patients fulfilling Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for unipolar depression and 16 healthy control subjects matched for age, gender, and education were included. All subjects underwent an event-related functional magnetic resonance imaging (fMRI) design with an adapted version of the Stroop task including congruent and incongruent task conditions. The fMRI experiment was conducted on a 1.5 T magnetic resonance (MR) scanner, and item responses were given manually by the subjects.
With regard to behavioral performance, patients revealed no differences in both reaction time and accuracy relative to control subjects. With regard to brain activations, direct comparison of patients with control subjects in the interference condition revealed hyperactivity in rostral anterior cingulate gyrus (rACG) and left dorsolateral prefrontal cortex (DLPFC) in depressive patients, which correlated strongly with the Stroop interference.
The study provides new evidence for the functioning and dissociation of the anterior cingulate in depressed patients. The greater prefrontal activation may reflect a cortical inefficiency due to hyperactivity in rACG enhancing the cognitive interferences from the emotional state.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16458263</pmid><doi>10.1016/j.biopsych.2005.10.025</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies anterior cingulated Attention - physiology Biological and medical sciences Brain Mapping Cerebral Cortex - physiopathology cognitive inhibition Color Perception - physiology Conflict (Psychology) Depression Depressive Disorder, Major - diagnosis Depressive Disorder, Major - physiopathology Dominance, Cerebral - physiology Electroencephalography Evoked Potentials, Visual - physiology Female functional magnetic resonance imaging Gyrus Cinguli - physiopathology Humans Image Processing, Computer-Assisted Inhibition (Psychology) Magnetic Resonance Imaging Major depressive disorder Male Medical sciences Middle Aged Mood disorders Neuropsychological Tests prefrontal cortex Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reading Reference Values Semantics Statistics as Topic Stroop task |
| title | Cortical Inefficiency in Patients with Unipolar Depression: An Event-Related fMRI Study with the Stroop Task |
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