Expression of Ki‐67 in squamous cell carcinoma of the penis
OBJECTIVE To investigate the Ki‐67 labelling index (LI) as a prognostic factor for the outcome of penile carcinoma, as in squamous cell carcinoma (SCC) of the larynx the expression of this marker correlates with histological features indicative of prognosis. PATIENTS AND METHODS We retrospectively a...
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| Veröffentlicht in: | BJU international 2005-07, Vol.96 (1), p.146-148 |
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| creator | Berdjis, Navid Meye, Axel Nippgen, Johannes Dittert, Dag Hakenberg, Oliver Baretton, Gustavo B. Wirth, Manfred P. |
| description | OBJECTIVE
To investigate the Ki‐67 labelling index (LI) as a prognostic factor for the outcome of penile carcinoma, as in squamous cell carcinoma (SCC) of the larynx the expression of this marker correlates with histological features indicative of prognosis.
PATIENTS AND METHODS
We retrospectively analysed the records of 44 patients in whom primary SCC of the penis was treated with amputation and bilateral lymphadenectomy (pT1, in 24, pT2 in 20, pN+ in 10; G1 in 12, G2 in 28 and G3 in four). During a mean follow‐up of 35.6 months, four patients had disease progression. Tumour tissue was stained immunohistochemically using the streptavidin‐biotin method. The mean Ki‐67 LI was defined as the percentage of total tumour cells that were Ki‐67‐positive. The results were compared with pathological tumour stage, grade, nodal status and clinical disease progression.
RESULTS
The mean (range) Ki‐67 LI was 40.5 (6.4–93.0)%; a high mean Ki‐67 LI was significantly inversely correlated with tumour differentiation (P |
| doi_str_mv | 10.1111/j.1464-410X.2005.05584.x |
| format | Article |
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To investigate the Ki‐67 labelling index (LI) as a prognostic factor for the outcome of penile carcinoma, as in squamous cell carcinoma (SCC) of the larynx the expression of this marker correlates with histological features indicative of prognosis.
PATIENTS AND METHODS
We retrospectively analysed the records of 44 patients in whom primary SCC of the penis was treated with amputation and bilateral lymphadenectomy (pT1, in 24, pT2 in 20, pN+ in 10; G1 in 12, G2 in 28 and G3 in four). During a mean follow‐up of 35.6 months, four patients had disease progression. Tumour tissue was stained immunohistochemically using the streptavidin‐biotin method. The mean Ki‐67 LI was defined as the percentage of total tumour cells that were Ki‐67‐positive. The results were compared with pathological tumour stage, grade, nodal status and clinical disease progression.
RESULTS
The mean (range) Ki‐67 LI was 40.5 (6.4–93.0)%; a high mean Ki‐67 LI was significantly inversely correlated with tumour differentiation (P < 0.005) and there was a tendency for a high Ki‐67 LI to be associated with advanced local tumour stage, nodal metastasis and clinical disease progression, but these correlations were not statistically significant (P = 0.07, 0.07 and 0.06, respectively).
CONCLUSIONS
The Ki‐67 LI is correlated with tumour grade in penile cancer, and may indicate a greater risk of nodal metastasis.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2005.05584.x</identifier><identifier>PMID: 15963138</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Ki-67 Antigen - metabolism ; Ki‐67 ; lymph nodes ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; penile carcinoma ; Penile Neoplasms - metabolism ; Prognosis ; Retrospective Studies ; Tumors</subject><ispartof>BJU international, 2005-07, Vol.96 (1), p.146-148</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4634-42a4dee32e70bbbc6fce3635e5f7aea19d749b7df38dc25c28e0bb9f179dbeb63</citedby><cites>FETCH-LOGICAL-c4634-42a4dee32e70bbbc6fce3635e5f7aea19d749b7df38dc25c28e0bb9f179dbeb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2005.05584.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2005.05584.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16877208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15963138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berdjis, Navid</creatorcontrib><creatorcontrib>Meye, Axel</creatorcontrib><creatorcontrib>Nippgen, Johannes</creatorcontrib><creatorcontrib>Dittert, Dag</creatorcontrib><creatorcontrib>Hakenberg, Oliver</creatorcontrib><creatorcontrib>Baretton, Gustavo B.</creatorcontrib><creatorcontrib>Wirth, Manfred P.</creatorcontrib><title>Expression of Ki‐67 in squamous cell carcinoma of the penis</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>OBJECTIVE
To investigate the Ki‐67 labelling index (LI) as a prognostic factor for the outcome of penile carcinoma, as in squamous cell carcinoma (SCC) of the larynx the expression of this marker correlates with histological features indicative of prognosis.
PATIENTS AND METHODS
We retrospectively analysed the records of 44 patients in whom primary SCC of the penis was treated with amputation and bilateral lymphadenectomy (pT1, in 24, pT2 in 20, pN+ in 10; G1 in 12, G2 in 28 and G3 in four). During a mean follow‐up of 35.6 months, four patients had disease progression. Tumour tissue was stained immunohistochemically using the streptavidin‐biotin method. The mean Ki‐67 LI was defined as the percentage of total tumour cells that were Ki‐67‐positive. The results were compared with pathological tumour stage, grade, nodal status and clinical disease progression.
RESULTS
The mean (range) Ki‐67 LI was 40.5 (6.4–93.0)%; a high mean Ki‐67 LI was significantly inversely correlated with tumour differentiation (P < 0.005) and there was a tendency for a high Ki‐67 LI to be associated with advanced local tumour stage, nodal metastasis and clinical disease progression, but these correlations were not statistically significant (P = 0.07, 0.07 and 0.06, respectively).
CONCLUSIONS
The Ki‐67 LI is correlated with tumour grade in penile cancer, and may indicate a greater risk of nodal metastasis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Ki‐67</subject><subject>lymph nodes</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>penile carcinoma</subject><subject>Penile Neoplasms - metabolism</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtOwzAQhi0EoqVwBZQN7BrsOLHjRRdQlWclNlRiZznORLjKq3Yj2h1H4IychIQGusUbj2a-sX99CHkE-6Q9V0ufhCwchwS_-gHGkY-jKA79zQEa_g0Of2ss2ACdOLfEuG2w6BgNSCQYJTQeoslsU1twzlSlV2Xek_n6-GTcM6XnVo0qqsZ5GvLc08pqU1aF6qj1G3g1lMadoqNM5Q7O-nuEFrezl-n9eP589zC9no91yGgbIVBhCkAD4DhJEs0yDZTRCKKMK1BEpDwUCU8zGqc6iHQQQ8uJjHCRJpAwOkKXu3drW60acGtZGNflUiW0ESXjImRC8BaMd6C2lXMWMllbUyi7lQTLTp1cys6K7AzJTp38USc37ep5_0eTFJDuF3tXLXDRA8pplWdWldq4PcdizgPccZMd925y2P47gLx5XHQV_QYjX4sk</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Berdjis, Navid</creator><creator>Meye, Axel</creator><creator>Nippgen, Johannes</creator><creator>Dittert, Dag</creator><creator>Hakenberg, Oliver</creator><creator>Baretton, Gustavo B.</creator><creator>Wirth, Manfred P.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>Expression of Ki‐67 in squamous cell carcinoma of the penis</title><author>Berdjis, Navid ; Meye, Axel ; Nippgen, Johannes ; Dittert, Dag ; Hakenberg, Oliver ; Baretton, Gustavo B. ; Wirth, Manfred P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4634-42a4dee32e70bbbc6fce3635e5f7aea19d749b7df38dc25c28e0bb9f179dbeb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Ki‐67</topic><topic>lymph nodes</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>penile carcinoma</topic><topic>Penile Neoplasms - metabolism</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berdjis, Navid</creatorcontrib><creatorcontrib>Meye, Axel</creatorcontrib><creatorcontrib>Nippgen, Johannes</creatorcontrib><creatorcontrib>Dittert, Dag</creatorcontrib><creatorcontrib>Hakenberg, Oliver</creatorcontrib><creatorcontrib>Baretton, Gustavo B.</creatorcontrib><creatorcontrib>Wirth, Manfred P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berdjis, Navid</au><au>Meye, Axel</au><au>Nippgen, Johannes</au><au>Dittert, Dag</au><au>Hakenberg, Oliver</au><au>Baretton, Gustavo B.</au><au>Wirth, Manfred P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Ki‐67 in squamous cell carcinoma of the penis</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2005-07</date><risdate>2005</risdate><volume>96</volume><issue>1</issue><spage>146</spage><epage>148</epage><pages>146-148</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><abstract>OBJECTIVE
To investigate the Ki‐67 labelling index (LI) as a prognostic factor for the outcome of penile carcinoma, as in squamous cell carcinoma (SCC) of the larynx the expression of this marker correlates with histological features indicative of prognosis.
PATIENTS AND METHODS
We retrospectively analysed the records of 44 patients in whom primary SCC of the penis was treated with amputation and bilateral lymphadenectomy (pT1, in 24, pT2 in 20, pN+ in 10; G1 in 12, G2 in 28 and G3 in four). During a mean follow‐up of 35.6 months, four patients had disease progression. Tumour tissue was stained immunohistochemically using the streptavidin‐biotin method. The mean Ki‐67 LI was defined as the percentage of total tumour cells that were Ki‐67‐positive. The results were compared with pathological tumour stage, grade, nodal status and clinical disease progression.
RESULTS
The mean (range) Ki‐67 LI was 40.5 (6.4–93.0)%; a high mean Ki‐67 LI was significantly inversely correlated with tumour differentiation (P < 0.005) and there was a tendency for a high Ki‐67 LI to be associated with advanced local tumour stage, nodal metastasis and clinical disease progression, but these correlations were not statistically significant (P = 0.07, 0.07 and 0.06, respectively).
CONCLUSIONS
The Ki‐67 LI is correlated with tumour grade in penile cancer, and may indicate a greater risk of nodal metastasis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15963138</pmid><doi>10.1111/j.1464-410X.2005.05584.x</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - metabolism Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Ki-67 Antigen - metabolism Ki‐67 lymph nodes Male Male genital diseases Medical sciences Middle Aged Nephrology. Urinary tract diseases penile carcinoma Penile Neoplasms - metabolism Prognosis Retrospective Studies Tumors |
| title | Expression of Ki‐67 in squamous cell carcinoma of the penis |
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