Regulation of CD8 + cytolytic T lymphocyte differentiation by a cholinergic pathway
In this report, we provide evidence that muscarinic receptors play a role in the generation of CD8 + cytolytic T lymphocytes. Analysis of mice with targeted deletions of each of the known muscarinic receptors (M 1–M 5) showed that CD8 + T cells from M 1 receptor-deficient mice had a defect in the ab...
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| Veröffentlicht in: | Journal of neuroimmunology 2005-07, Vol.164 (1), p.66-75 |
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| container_title | Journal of neuroimmunology |
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| creator | Zimring, James C. Kapp, Linda M. Yamada, Masahisa Wess, Jürgen Kapp, Judith A. |
| description | In this report, we provide evidence that muscarinic receptors play a role in the generation of CD8
+ cytolytic T lymphocytes. Analysis of mice with targeted deletions of each of the known muscarinic receptors (M
1–M
5) showed that CD8
+ T cells from M
1 receptor-deficient mice had a defect in the ability to differentiate into cytolytic T lymphocytes. Additional pharmacological experiments support the role of muscarinic receptors in wild type mice and suggest that acetylcholine may be involved. Together, these findings suggest that the M
1 muscarinic receptor is involved in CTL development, thus providing novel insights into CD8
+ T cell biology and the potential role of cholinergic signaling in immune regulation. |
| doi_str_mv | 10.1016/j.jneuroim.2005.03.018 |
| format | Article |
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+ cytolytic T lymphocytes. Analysis of mice with targeted deletions of each of the known muscarinic receptors (M
1–M
5) showed that CD8
+ T cells from M
1 receptor-deficient mice had a defect in the ability to differentiate into cytolytic T lymphocytes. Additional pharmacological experiments support the role of muscarinic receptors in wild type mice and suggest that acetylcholine may be involved. Together, these findings suggest that the M
1 muscarinic receptor is involved in CTL development, thus providing novel insights into CD8
+ T cell biology and the potential role of cholinergic signaling in immune regulation.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2005.03.018</identifier><identifier>PMID: 15913791</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acetylcholine ; Acetylcholine - pharmacology ; Animals ; Blotting, Northern - methods ; CD3 Complex - metabolism ; CD8-Positive T-Lymphocytes - cytology ; CD8-Positive T-Lymphocytes - drug effects ; CD8-Positive T-Lymphocytes - physiology ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; Cell Survival - drug effects ; Cell Survival - physiology ; Cells, Cultured ; Cytotoxic T lymphocyte ; Dose-Response Relationship, Drug ; Female ; Flow Cytometry - methods ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Muscarinic Antagonists - pharmacology ; Neuroimmunology ; Receptor, Muscarinic M1 - deficiency ; Receptor, Muscarinic M1 - physiology ; Receptors, Muscarinic - classification ; Receptors, Muscarinic - genetics ; Receptors, Muscarinic - metabolism ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - biosynthesis ; T cells ; Time Factors</subject><ispartof>Journal of neuroimmunology, 2005-07, Vol.164 (1), p.66-75</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-bbacb5a74cd5886da6cd90a0649cdfc3ba3908afb1bc466053e070b3199040673</citedby><cites>FETCH-LOGICAL-c366t-bbacb5a74cd5886da6cd90a0649cdfc3ba3908afb1bc466053e070b3199040673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2005.03.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15913791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimring, James C.</creatorcontrib><creatorcontrib>Kapp, Linda M.</creatorcontrib><creatorcontrib>Yamada, Masahisa</creatorcontrib><creatorcontrib>Wess, Jürgen</creatorcontrib><creatorcontrib>Kapp, Judith A.</creatorcontrib><title>Regulation of CD8 + cytolytic T lymphocyte differentiation by a cholinergic pathway</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>In this report, we provide evidence that muscarinic receptors play a role in the generation of CD8
+ cytolytic T lymphocytes. Analysis of mice with targeted deletions of each of the known muscarinic receptors (M
1–M
5) showed that CD8
+ T cells from M
1 receptor-deficient mice had a defect in the ability to differentiate into cytolytic T lymphocytes. Additional pharmacological experiments support the role of muscarinic receptors in wild type mice and suggest that acetylcholine may be involved. Together, these findings suggest that the M
1 muscarinic receptor is involved in CTL development, thus providing novel insights into CD8
+ T cell biology and the potential role of cholinergic signaling in immune regulation.</description><subject>Acetylcholine</subject><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Blotting, Northern - methods</subject><subject>CD3 Complex - metabolism</subject><subject>CD8-Positive T-Lymphocytes - cytology</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>CD8-Positive T-Lymphocytes - physiology</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - physiology</subject><subject>Cells, Cultured</subject><subject>Cytotoxic T lymphocyte</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Flow Cytometry - methods</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>Neuroimmunology</subject><subject>Receptor, Muscarinic M1 - deficiency</subject><subject>Receptor, Muscarinic M1 - physiology</subject><subject>Receptors, Muscarinic - classification</subject><subject>Receptors, Muscarinic - genetics</subject><subject>Receptors, Muscarinic - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - biosynthesis</subject><subject>T cells</subject><subject>Time Factors</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BcnJi7RONm3a3JT1EwTBj3NI0qmbpW3WpFX6763sikdPA8Pzzss8hJwySBkwcbFKVx0Owbs2nQPkKfAUWLlDZqws5kmZzdkumU1gnuTFvDwghzGuAFjOM7lPDlguGS8km5GXZ3wfGt0731Ff08V1Sc-pHXvfjL2z9JU2Y7te-mmDtHJ1jQG73m14M1JN7dI3rsPwPtFr3S-_9HhM9mrdRDzZziPydnvzurhPHp_uHhZXj4nlQvSJMdqaXBeZrfKyFJUWtpKgQWTSVrXlRnMJpa4NMzYTAnKOUIDhTErIQBT8iJxt7q6D_xgw9qp10WLT6A79EJUoZCYKARMoNqANPsaAtVoH1-owKgbqR6daqV-d6kenAq4mnVPwdNswmBarv9jW3wRcbgCc_vx0GFS0DjuLlQtoe1V591_HNwigirU</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Zimring, James C.</creator><creator>Kapp, Linda M.</creator><creator>Yamada, Masahisa</creator><creator>Wess, Jürgen</creator><creator>Kapp, Judith A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Regulation of CD8 + cytolytic T lymphocyte differentiation by a cholinergic pathway</title><author>Zimring, James C. ; Kapp, Linda M. ; Yamada, Masahisa ; Wess, Jürgen ; Kapp, Judith A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-bbacb5a74cd5886da6cd90a0649cdfc3ba3908afb1bc466053e070b3199040673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetylcholine</topic><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Blotting, Northern - methods</topic><topic>CD3 Complex - metabolism</topic><topic>CD8-Positive T-Lymphocytes - cytology</topic><topic>CD8-Positive T-Lymphocytes - drug effects</topic><topic>CD8-Positive T-Lymphocytes - physiology</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - physiology</topic><topic>Cells, Cultured</topic><topic>Cytotoxic T lymphocyte</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Flow Cytometry - methods</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>Neuroimmunology</topic><topic>Receptor, Muscarinic M1 - deficiency</topic><topic>Receptor, Muscarinic M1 - physiology</topic><topic>Receptors, Muscarinic - classification</topic><topic>Receptors, Muscarinic - genetics</topic><topic>Receptors, Muscarinic - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - biosynthesis</topic><topic>T cells</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimring, James C.</creatorcontrib><creatorcontrib>Kapp, Linda M.</creatorcontrib><creatorcontrib>Yamada, Masahisa</creatorcontrib><creatorcontrib>Wess, Jürgen</creatorcontrib><creatorcontrib>Kapp, Judith A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zimring, James C.</au><au>Kapp, Linda M.</au><au>Yamada, Masahisa</au><au>Wess, Jürgen</au><au>Kapp, Judith A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of CD8 + cytolytic T lymphocyte differentiation by a cholinergic pathway</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>164</volume><issue>1</issue><spage>66</spage><epage>75</epage><pages>66-75</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>In this report, we provide evidence that muscarinic receptors play a role in the generation of CD8
+ cytolytic T lymphocytes. Analysis of mice with targeted deletions of each of the known muscarinic receptors (M
1–M
5) showed that CD8
+ T cells from M
1 receptor-deficient mice had a defect in the ability to differentiate into cytolytic T lymphocytes. Additional pharmacological experiments support the role of muscarinic receptors in wild type mice and suggest that acetylcholine may be involved. Together, these findings suggest that the M
1 muscarinic receptor is involved in CTL development, thus providing novel insights into CD8
+ T cell biology and the potential role of cholinergic signaling in immune regulation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15913791</pmid><doi>10.1016/j.jneuroim.2005.03.018</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetylcholine Acetylcholine - pharmacology Animals Blotting, Northern - methods CD3 Complex - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - physiology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Cytotoxic T lymphocyte Dose-Response Relationship, Drug Female Flow Cytometry - methods Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Muscarinic Antagonists - pharmacology Neuroimmunology Receptor, Muscarinic M1 - deficiency Receptor, Muscarinic M1 - physiology Receptors, Muscarinic - classification Receptors, Muscarinic - genetics Receptors, Muscarinic - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis T cells Time Factors |
| title | Regulation of CD8 + cytolytic T lymphocyte differentiation by a cholinergic pathway |
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