The molecular physiology and pathology of fibrin structure/function
The formation of a fibrin clot is a pivotal event in atherothrombotic vascular disease and there is mounting evidence that the structure of clots is of importance in the development of disease. This review describes the crucial events in the formation and dissolution of a clot, with particular focus...
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| Veröffentlicht in: | Blood reviews 2005-09, Vol.19 (5), p.275-288 |
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| container_end_page | 288 |
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| container_issue | 5 |
| container_start_page | 275 |
| container_title | Blood reviews |
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| creator | Standeven, Kristina F. Ariëns, Robert A.S. Grant, Peter J. |
| description | The formation of a fibrin clot is a pivotal event in atherothrombotic vascular disease and there is mounting evidence that the structure of clots is of importance in the development of disease. This review describes the crucial events in the formation and dissolution of a clot, with particular focus on genetic and environmental factors that have been identified as determinants of fibrin structure in vivo, and discusses the substantiation of the relationship between fibrin structure and disease in conjunction with a review of the current literature. |
| doi_str_mv | 10.1016/j.blre.2005.01.003 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0268-960X |
| ispartof | Blood reviews, 2005-09, Vol.19 (5), p.275-288 |
| issn | 0268-960X 1532-1681 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Blood Coagulation - physiology Environment Factor XIII Factor XIIIa - chemistry Factor XIIIa - physiology Fibrin Fibrin - chemistry Fibrin - physiology Fibrin structure Fibrinogen Fibrinogen - physiology Genetic Haemostasis Hematologic and hematopoietic diseases Humans Medical sciences Structure-Activity Relationship Thrombosis Thrombosis - blood Vascular disease Vascular Diseases - blood |
| title | The molecular physiology and pathology of fibrin structure/function |
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