The role of antifibrinolytic agents in gynecologic cancer surgery
To compare the effects of crystalloid and colloid solutions, tranexamic acid and epsilon-aminocaproic acid on the need for allogenic blood transfusion and on coagulation and fibrinolysis parameters. We conducted the study in the Anesthesiology and Reanimation Department of Hacettepe University Medic...
Gespeichert in:
| Veröffentlicht in: | Saudi medical journal 2006-05, Vol.27 (5), p.637-641 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 641 |
|---|---|
| container_issue | 5 |
| container_start_page | 637 |
| container_title | Saudi medical journal |
| container_volume | 27 |
| creator | CELEBI, Nalan CELEBIOGLU, Bilge SELCUK, Mehtap CANBAY, Ozgur KARAGOZ, Ayse H AYPAR, Ulku |
| description | To compare the effects of crystalloid and colloid solutions, tranexamic acid and epsilon-aminocaproic acid on the need for allogenic blood transfusion and on coagulation and fibrinolysis parameters.
We conducted the study in the Anesthesiology and Reanimation Department of Hacettepe University Medical Faculty, Ankara, Turkey between March 2004 and April 2005. The study included 105 patients, classified by the American Society of Anesthesiology as physical status groups I-II, undergoing gynecologic cancer treatment. We divided them into 5 groups: group I (crystalloid) received crystalloid solutions, group II (colloid) received colloid solutions, group III (tranexamic acid) received 10 mg x kg(-1) tranexamic acid, and group 5 (epsilon-aminocaproic acid) received 100 mg x kg(-1) epsilon-aminocaproic acid. All patients bleeding amount was measured and recorded perioperatively, and at the 12th and 24th hours postoperatively. We then evaluated the patients' hemoglobin, hematocrit, activated thromboplastin time, international normalized ration, fibrinogen, and thrombocyte count and symptoms of pulmonary embolism.
In comparing the amount of bleeding, the bleeding in the tranexamic acid group was 30.8% less than the crystalloid group (p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67945051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67945051</sourcerecordid><originalsourceid>FETCH-LOGICAL-p239t-811ab1f8c72a7efc893865c0d91c8351ee1abee49f18b3b94c694085ed46d0e43</originalsourceid><addsrcrecordid>eNpFzztrwzAUBWANLU2a9i8ULe1mkKyHpTGEviDQJZ2NLF-5KoqUSvbgf19DUzIduOfjwrlCa8IaXYla8RW6LeWbECYlkTdoRaVUpBb1Gm0PX4BzCoCTwyaO3vku-5jCPHqLzQBxLNhHPMwRbAppWK7WRAsZlykPkOc7dO1MKHB_zg36fHk-7N6q_cfr-267r04102OlKDUddco2tWnAWaWZksKSXlOrmKAASw_AtaOqY53mVmpOlICey54AZxv09Pf3lNPPBGVsj75YCMFESFNpZaO5IIIu8OEMp-4IfXvK_mjy3P6PXsDjGZhiTXB52ePLxTWNVIpQ9gtGKF9K</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67945051</pqid></control><display><type>article</type><title>The role of antifibrinolytic agents in gynecologic cancer surgery</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>CELEBI, Nalan ; CELEBIOGLU, Bilge ; SELCUK, Mehtap ; CANBAY, Ozgur ; KARAGOZ, Ayse H ; AYPAR, Ulku</creator><creatorcontrib>CELEBI, Nalan ; CELEBIOGLU, Bilge ; SELCUK, Mehtap ; CANBAY, Ozgur ; KARAGOZ, Ayse H ; AYPAR, Ulku</creatorcontrib><description>To compare the effects of crystalloid and colloid solutions, tranexamic acid and epsilon-aminocaproic acid on the need for allogenic blood transfusion and on coagulation and fibrinolysis parameters.
We conducted the study in the Anesthesiology and Reanimation Department of Hacettepe University Medical Faculty, Ankara, Turkey between March 2004 and April 2005. The study included 105 patients, classified by the American Society of Anesthesiology as physical status groups I-II, undergoing gynecologic cancer treatment. We divided them into 5 groups: group I (crystalloid) received crystalloid solutions, group II (colloid) received colloid solutions, group III (tranexamic acid) received 10 mg x kg(-1) tranexamic acid, and group 5 (epsilon-aminocaproic acid) received 100 mg x kg(-1) epsilon-aminocaproic acid. All patients bleeding amount was measured and recorded perioperatively, and at the 12th and 24th hours postoperatively. We then evaluated the patients' hemoglobin, hematocrit, activated thromboplastin time, international normalized ration, fibrinogen, and thrombocyte count and symptoms of pulmonary embolism.
In comparing the amount of bleeding, the bleeding in the tranexamic acid group was 30.8% less than the crystalloid group (p<0.05), 33.3% less than the colloid group (p<0.05), and 23.9% less than the epsilon-aminocaproic acid group (p<0.05).
When the negative effects of blood transfusions were considered, tranexamic acid administration can be recommended for decreasing the need for blood transfusion in gynecologic cancer surgery.</description><identifier>ISSN: 0379-5284</identifier><identifier>PMID: 16680252</identifier><identifier>CODEN: SAMJDI</identifier><language>eng</language><publisher>Riyadh: Saudi Medical Journal</publisher><subject>Aminocaproic Acid - administration & dosage ; Antifibrinolytic Agents - administration & dosage ; Biological and medical sciences ; Blood Coagulation - physiology ; Colloids - administration & dosage ; Female ; Fibrinogen - analysis ; Fibrinolysis - physiology ; General aspects ; Genital Neoplasms, Female - surgery ; Hematocrit ; Hemoglobins - analysis ; Humans ; International Normalized Ratio ; Isotonic Solutions - administration & dosage ; Medical sciences ; Partial Thromboplastin Time ; Platelet Count ; Pulmonary Embolism - diagnosis ; Tranexamic Acid - administration & dosage ; Turkey</subject><ispartof>Saudi medical journal, 2006-05, Vol.27 (5), p.637-641</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17768801$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16680252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CELEBI, Nalan</creatorcontrib><creatorcontrib>CELEBIOGLU, Bilge</creatorcontrib><creatorcontrib>SELCUK, Mehtap</creatorcontrib><creatorcontrib>CANBAY, Ozgur</creatorcontrib><creatorcontrib>KARAGOZ, Ayse H</creatorcontrib><creatorcontrib>AYPAR, Ulku</creatorcontrib><title>The role of antifibrinolytic agents in gynecologic cancer surgery</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To compare the effects of crystalloid and colloid solutions, tranexamic acid and epsilon-aminocaproic acid on the need for allogenic blood transfusion and on coagulation and fibrinolysis parameters.
We conducted the study in the Anesthesiology and Reanimation Department of Hacettepe University Medical Faculty, Ankara, Turkey between March 2004 and April 2005. The study included 105 patients, classified by the American Society of Anesthesiology as physical status groups I-II, undergoing gynecologic cancer treatment. We divided them into 5 groups: group I (crystalloid) received crystalloid solutions, group II (colloid) received colloid solutions, group III (tranexamic acid) received 10 mg x kg(-1) tranexamic acid, and group 5 (epsilon-aminocaproic acid) received 100 mg x kg(-1) epsilon-aminocaproic acid. All patients bleeding amount was measured and recorded perioperatively, and at the 12th and 24th hours postoperatively. We then evaluated the patients' hemoglobin, hematocrit, activated thromboplastin time, international normalized ration, fibrinogen, and thrombocyte count and symptoms of pulmonary embolism.
In comparing the amount of bleeding, the bleeding in the tranexamic acid group was 30.8% less than the crystalloid group (p<0.05), 33.3% less than the colloid group (p<0.05), and 23.9% less than the epsilon-aminocaproic acid group (p<0.05).
When the negative effects of blood transfusions were considered, tranexamic acid administration can be recommended for decreasing the need for blood transfusion in gynecologic cancer surgery.</description><subject>Aminocaproic Acid - administration & dosage</subject><subject>Antifibrinolytic Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation - physiology</subject><subject>Colloids - administration & dosage</subject><subject>Female</subject><subject>Fibrinogen - analysis</subject><subject>Fibrinolysis - physiology</subject><subject>General aspects</subject><subject>Genital Neoplasms, Female - surgery</subject><subject>Hematocrit</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>International Normalized Ratio</subject><subject>Isotonic Solutions - administration & dosage</subject><subject>Medical sciences</subject><subject>Partial Thromboplastin Time</subject><subject>Platelet Count</subject><subject>Pulmonary Embolism - diagnosis</subject><subject>Tranexamic Acid - administration & dosage</subject><subject>Turkey</subject><issn>0379-5284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFzztrwzAUBWANLU2a9i8ULe1mkKyHpTGEviDQJZ2NLF-5KoqUSvbgf19DUzIduOfjwrlCa8IaXYla8RW6LeWbECYlkTdoRaVUpBb1Gm0PX4BzCoCTwyaO3vku-5jCPHqLzQBxLNhHPMwRbAppWK7WRAsZlykPkOc7dO1MKHB_zg36fHk-7N6q_cfr-267r04102OlKDUddco2tWnAWaWZksKSXlOrmKAASw_AtaOqY53mVmpOlICey54AZxv09Pf3lNPPBGVsj75YCMFESFNpZaO5IIIu8OEMp-4IfXvK_mjy3P6PXsDjGZhiTXB52ePLxTWNVIpQ9gtGKF9K</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>CELEBI, Nalan</creator><creator>CELEBIOGLU, Bilge</creator><creator>SELCUK, Mehtap</creator><creator>CANBAY, Ozgur</creator><creator>KARAGOZ, Ayse H</creator><creator>AYPAR, Ulku</creator><general>Saudi Medical Journal</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>The role of antifibrinolytic agents in gynecologic cancer surgery</title><author>CELEBI, Nalan ; CELEBIOGLU, Bilge ; SELCUK, Mehtap ; CANBAY, Ozgur ; KARAGOZ, Ayse H ; AYPAR, Ulku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-811ab1f8c72a7efc893865c0d91c8351ee1abee49f18b3b94c694085ed46d0e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aminocaproic Acid - administration & dosage</topic><topic>Antifibrinolytic Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation - physiology</topic><topic>Colloids - administration & dosage</topic><topic>Female</topic><topic>Fibrinogen - analysis</topic><topic>Fibrinolysis - physiology</topic><topic>General aspects</topic><topic>Genital Neoplasms, Female - surgery</topic><topic>Hematocrit</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>International Normalized Ratio</topic><topic>Isotonic Solutions - administration & dosage</topic><topic>Medical sciences</topic><topic>Partial Thromboplastin Time</topic><topic>Platelet Count</topic><topic>Pulmonary Embolism - diagnosis</topic><topic>Tranexamic Acid - administration & dosage</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CELEBI, Nalan</creatorcontrib><creatorcontrib>CELEBIOGLU, Bilge</creatorcontrib><creatorcontrib>SELCUK, Mehtap</creatorcontrib><creatorcontrib>CANBAY, Ozgur</creatorcontrib><creatorcontrib>KARAGOZ, Ayse H</creatorcontrib><creatorcontrib>AYPAR, Ulku</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CELEBI, Nalan</au><au>CELEBIOGLU, Bilge</au><au>SELCUK, Mehtap</au><au>CANBAY, Ozgur</au><au>KARAGOZ, Ayse H</au><au>AYPAR, Ulku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of antifibrinolytic agents in gynecologic cancer surgery</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>27</volume><issue>5</issue><spage>637</spage><epage>641</epage><pages>637-641</pages><issn>0379-5284</issn><coden>SAMJDI</coden><abstract>To compare the effects of crystalloid and colloid solutions, tranexamic acid and epsilon-aminocaproic acid on the need for allogenic blood transfusion and on coagulation and fibrinolysis parameters.
We conducted the study in the Anesthesiology and Reanimation Department of Hacettepe University Medical Faculty, Ankara, Turkey between March 2004 and April 2005. The study included 105 patients, classified by the American Society of Anesthesiology as physical status groups I-II, undergoing gynecologic cancer treatment. We divided them into 5 groups: group I (crystalloid) received crystalloid solutions, group II (colloid) received colloid solutions, group III (tranexamic acid) received 10 mg x kg(-1) tranexamic acid, and group 5 (epsilon-aminocaproic acid) received 100 mg x kg(-1) epsilon-aminocaproic acid. All patients bleeding amount was measured and recorded perioperatively, and at the 12th and 24th hours postoperatively. We then evaluated the patients' hemoglobin, hematocrit, activated thromboplastin time, international normalized ration, fibrinogen, and thrombocyte count and symptoms of pulmonary embolism.
In comparing the amount of bleeding, the bleeding in the tranexamic acid group was 30.8% less than the crystalloid group (p<0.05), 33.3% less than the colloid group (p<0.05), and 23.9% less than the epsilon-aminocaproic acid group (p<0.05).
When the negative effects of blood transfusions were considered, tranexamic acid administration can be recommended for decreasing the need for blood transfusion in gynecologic cancer surgery.</abstract><cop>Riyadh</cop><pub>Saudi Medical Journal</pub><pmid>16680252</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0379-5284 |
| ispartof | Saudi medical journal, 2006-05, Vol.27 (5), p.637-641 |
| issn | 0379-5284 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67945051 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aminocaproic Acid - administration & dosage Antifibrinolytic Agents - administration & dosage Biological and medical sciences Blood Coagulation - physiology Colloids - administration & dosage Female Fibrinogen - analysis Fibrinolysis - physiology General aspects Genital Neoplasms, Female - surgery Hematocrit Hemoglobins - analysis Humans International Normalized Ratio Isotonic Solutions - administration & dosage Medical sciences Partial Thromboplastin Time Platelet Count Pulmonary Embolism - diagnosis Tranexamic Acid - administration & dosage Turkey |
| title | The role of antifibrinolytic agents in gynecologic cancer surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T21%3A50%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20antifibrinolytic%20agents%20in%20gynecologic%20cancer%20surgery&rft.jtitle=Saudi%20medical%20journal&rft.au=CELEBI,%20Nalan&rft.date=2006-05-01&rft.volume=27&rft.issue=5&rft.spage=637&rft.epage=641&rft.pages=637-641&rft.issn=0379-5284&rft.coden=SAMJDI&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E67945051%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67945051&rft_id=info:pmid/16680252&rfr_iscdi=true |