The ICAM-1 469 T/C gene polymorphism but not 241 G/A is associated with Behçets disease in the Lebanese population
To investigate the association of the 2 intracellular adhesion molecules-1 (ICAM-1) gene polymorphisms [thymidine/cytidine (T/C) 469 and guanosine/adenosine (G/A) 241] in Behçets disease in Lebanon. We initiated the study in July 2003, and carried out the work in the research laboratory of Beirut Ar...
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| Veröffentlicht in: | Saudi medical journal 2006-05, Vol.27 (5), p.604-607 |
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| creator | Chmaisse, Hania N Fakhoury, Hana A Salti, Nuha N Makki, Rajaa F |
| description | To investigate the association of the 2 intracellular adhesion molecules-1 (ICAM-1) gene polymorphisms [thymidine/cytidine (T/C) 469 and guanosine/adenosine (G/A) 241] in Behçets disease in Lebanon.
We initiated the study in July 2003, and carried out the work in the research laboratory of Beirut Arab University, Beirut, Lebanon. We extracted the DNA by glass fiber matrix mini column. We amplified the ICAM gene by polymerase chain reaction (PCR) and tested the PCR products for the presence of the polymorphisms using a restriction enzyme specific for each polymorphism. We analyzed the results by agarose electrophoresis.
We demonstrated the association of only one single nucleotide polymorphism (SNP) (K469) with Behçets disease, while we could not detect the other SNP (G241A) in either controls or patients in the Lebanese population.
The ICAM-1 gene polymorphism 469 T/C, but not 241 G/A, may encode risk for Behçets disease in the Lebanese population. |
| format | Article |
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We initiated the study in July 2003, and carried out the work in the research laboratory of Beirut Arab University, Beirut, Lebanon. We extracted the DNA by glass fiber matrix mini column. We amplified the ICAM gene by polymerase chain reaction (PCR) and tested the PCR products for the presence of the polymorphisms using a restriction enzyme specific for each polymorphism. We analyzed the results by agarose electrophoresis.
We demonstrated the association of only one single nucleotide polymorphism (SNP) (K469) with Behçets disease, while we could not detect the other SNP (G241A) in either controls or patients in the Lebanese population.
The ICAM-1 gene polymorphism 469 T/C, but not 241 G/A, may encode risk for Behçets disease in the Lebanese population.</description><identifier>ISSN: 0379-5284</identifier><identifier>PMID: 16680245</identifier><language>eng</language><publisher>Saudi Arabia</publisher><subject>Adolescent ; Adult ; Behcet Syndrome - genetics ; Case-Control Studies ; Female ; Genotype ; Humans ; Intercellular Adhesion Molecule-1 - genetics ; Lebanon - epidemiology ; Male ; Polymorphism, Genetic</subject><ispartof>Saudi medical journal, 2006-05, Vol.27 (5), p.604-607</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16680245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chmaisse, Hania N</creatorcontrib><creatorcontrib>Fakhoury, Hana A</creatorcontrib><creatorcontrib>Salti, Nuha N</creatorcontrib><creatorcontrib>Makki, Rajaa F</creatorcontrib><title>The ICAM-1 469 T/C gene polymorphism but not 241 G/A is associated with Behçets disease in the Lebanese population</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To investigate the association of the 2 intracellular adhesion molecules-1 (ICAM-1) gene polymorphisms [thymidine/cytidine (T/C) 469 and guanosine/adenosine (G/A) 241] in Behçets disease in Lebanon.
We initiated the study in July 2003, and carried out the work in the research laboratory of Beirut Arab University, Beirut, Lebanon. We extracted the DNA by glass fiber matrix mini column. We amplified the ICAM gene by polymerase chain reaction (PCR) and tested the PCR products for the presence of the polymorphisms using a restriction enzyme specific for each polymorphism. We analyzed the results by agarose electrophoresis.
We demonstrated the association of only one single nucleotide polymorphism (SNP) (K469) with Behçets disease, while we could not detect the other SNP (G241A) in either controls or patients in the Lebanese population.
The ICAM-1 gene polymorphism 469 T/C, but not 241 G/A, may encode risk for Behçets disease in the Lebanese population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Behcet Syndrome - genetics</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Lebanon - epidemiology</subject><subject>Male</subject><subject>Polymorphism, Genetic</subject><issn>0379-5284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtOw0AURV2ASAhsAb2KzsrY8y9DBAEpiMa9Nbaf8SD_8BsLZUUshI1hBFS3OTo6umfRmnFtY5kasYouid4Y40oxdRGtEqUMS4VcR5Q1CE_73XOcgFAWsu0eXrFHGIf21A3T2HjqoJgD9EOAVCRw2O7AEziiofQuYAUfPjRwh83XJwaCyhM6QvA9hMV9xML1SD_CcW5d8EN_FZ3XriW8_ttNlD3cZ_vH-PhyWFKO8SiFjHEJL02CpSx1WqpCC51wmRiunS0wLbgwtuScSWedZRrTKjW1cU5Yq6Wta76Jbn-14zS8z0gh7zyV2LZLzzBTrrQVkiV6AW_-wLnosMrHyXduOuX_L_Fv6NxgsA</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Chmaisse, Hania N</creator><creator>Fakhoury, Hana A</creator><creator>Salti, Nuha N</creator><creator>Makki, Rajaa F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>The ICAM-1 469 T/C gene polymorphism but not 241 G/A is associated with Behçets disease in the Lebanese population</title><author>Chmaisse, Hania N ; Fakhoury, Hana A ; Salti, Nuha N ; Makki, Rajaa F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p545-e528c81ec5c72c6b7471351837a9be2b3489c3305a9a907e2d28f8aa499759ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Behcet Syndrome - genetics</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>Lebanon - epidemiology</topic><topic>Male</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chmaisse, Hania N</creatorcontrib><creatorcontrib>Fakhoury, Hana A</creatorcontrib><creatorcontrib>Salti, Nuha N</creatorcontrib><creatorcontrib>Makki, Rajaa F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chmaisse, Hania N</au><au>Fakhoury, Hana A</au><au>Salti, Nuha N</au><au>Makki, Rajaa F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ICAM-1 469 T/C gene polymorphism but not 241 G/A is associated with Behçets disease in the Lebanese population</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2006-05</date><risdate>2006</risdate><volume>27</volume><issue>5</issue><spage>604</spage><epage>607</epage><pages>604-607</pages><issn>0379-5284</issn><abstract>To investigate the association of the 2 intracellular adhesion molecules-1 (ICAM-1) gene polymorphisms [thymidine/cytidine (T/C) 469 and guanosine/adenosine (G/A) 241] in Behçets disease in Lebanon.
We initiated the study in July 2003, and carried out the work in the research laboratory of Beirut Arab University, Beirut, Lebanon. We extracted the DNA by glass fiber matrix mini column. We amplified the ICAM gene by polymerase chain reaction (PCR) and tested the PCR products for the presence of the polymorphisms using a restriction enzyme specific for each polymorphism. We analyzed the results by agarose electrophoresis.
We demonstrated the association of only one single nucleotide polymorphism (SNP) (K469) with Behçets disease, while we could not detect the other SNP (G241A) in either controls or patients in the Lebanese population.
The ICAM-1 gene polymorphism 469 T/C, but not 241 G/A, may encode risk for Behçets disease in the Lebanese population.</abstract><cop>Saudi Arabia</cop><pmid>16680245</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Saudi medical journal, 2006-05, Vol.27 (5), p.604-607 |
| issn | 0379-5284 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Behcet Syndrome - genetics Case-Control Studies Female Genotype Humans Intercellular Adhesion Molecule-1 - genetics Lebanon - epidemiology Male Polymorphism, Genetic |
| title | The ICAM-1 469 T/C gene polymorphism but not 241 G/A is associated with Behçets disease in the Lebanese population |
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