High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance

Although HLA class I alleles can bind epitopes up to 14 amino acids in length, little is known about the immunogenicity or the responding T-cell repertoire against such determinants. Here, we describe an HLA-B*3508-restricted cytotoxic T lymphocyte response to a 13-mer viral epitope (LPEPLPQGQLTAY)....

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Veröffentlicht in:	The Journal of biological chemistry 2005-06, Vol.280 (25), p.23900-23909
Hauptverfasser:	Tynan, Fleur E, Borg, Natalie A, Miles, John J, Beddoe, Travis, El-Hassen, Diah, Silins, Sharon L, van Zuylen, Wendy J M, Purcell, Anthony W, Kjer-Nielsen, Lars, McCluskey, James, Burrows, Scott R, Rossjohn, Jamie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Cell Line Flow Cytometry Histocompatibility Antigens Class I - metabolism Humans Immunodominant Epitopes - chemistry Immunodominant Epitopes - metabolism Models, Molecular Molecular Sequence Data Molecular Structure Receptors, Antigen, T-Cell - metabolism T-Lymphocytes, Cytotoxic - immunology
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