Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells

We have found in the previous study that 6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid isolated from Hylomecon species, may have potential as a chemotherapeutic agent. However, the mechanisms of 6ME-induced cell death have not been investigated. The purpose of the present study...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 2005-07, Vol.70 (2), p.242-248
Hauptverfasser:	Yin, Hu-Quan, Kim, Young-Ho, Moon, Chang-Kiu, Lee, Byung-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Methoxydihydrosanguinarine (6ME) Alkaloids - isolation & purification Alkaloids - pharmacology Antioxidant Apoptosis Apoptosis - drug effects Apoptosis - physiology Benzophenanthridines Biological and medical sciences Cell Line, Tumor Cytochrome c HepG2 Humans Isoquinolines Medical sciences p53/bax Pharmacology. Drug treatments Phenanthridines - isolation & purification Phenanthridines - pharmacology Plant Extracts - isolation & purification Plant Extracts - pharmacology Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!