Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T Cells

ADAP (adhesion and degranulation-promoting adaptor protein) and SKAP55 (Src kinase-associated phosphoprotein of 55 kDa) are T cell adaptors that mediate inside-out signaling from the T cell antigen receptor to integrins, giving rise to increased integrin affinity/avidity and formation of the immunol...

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Veröffentlicht in:	The Journal of biological chemistry 2005-06, Vol.280 (25), p.23576-23583
Hauptverfasser:	Huang, Yanping, Norton, Darrell D., Precht, Patricia, Martindale, Jennifer L., Burkhardt, Janis K., Wange, Ronald L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - physiology Base Sequence DNA Primers Humans Jurkat Cells Phosphoproteins - physiology Signal Transduction T-Lymphocytes - metabolism
Online-Zugang:	Volltext
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