Cullin 4A-mediated Proteolysis of DDB2 Protein at DNA Damage Sites Regulates in Vivo Lesion Recognition by XPC

Xeroderma pigmentosum (XP) complementation group E gene product, damaged DNA-binding protein 2 (DDB2), is a subunit of the DDB heterodimeric protein complex with high specificity for binding to a variety of DNA helix-distorting lesions. DDB is believed to play a role in the initial step of damage re...

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Veröffentlicht in:	The Journal of biological chemistry 2006-05, Vol.281 (19), p.13404-13411
Hauptverfasser:	El-Mahdy, Mohamed A., Zhu, Qianzheng, Wang, Qi-en, Wani, Gulzar, Prætorius-Ibba, Mette, Wani, Altaf A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Chromatin - metabolism Cullin Proteins - genetics Cullin Proteins - metabolism DNA Damage - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Silencing Humans Leupeptins Pyrimidine Dimers - metabolism Signal Transduction Ubiquitin - metabolism Ultraviolet Rays
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