The jejunal Peyer's patches are the major inductive sites of the F4-specific immune response following intestinal immunisation of pigs with F4 (K88) fimbriae
A recently developed oral immunisation model in pigs in which F4 (K88) fimbriae of enterotoxigenic Escherichia coli are administered to induce a protective intestinal immunity, was used to determine the optimal inductive sites of the F4-specific intestinal immune response. Hereto, pigs were immunise...
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| Veröffentlicht in: | Vaccine 2006-05, Vol.24 (18), p.3812-3820 |
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| creator | Snoeck, V. Verfaillie, T. Verdonck, F. Goddeeris, B.M. Cox, E. |
| description | A recently developed oral immunisation model in pigs in which F4 (K88) fimbriae of enterotoxigenic
Escherichia coli are administered to induce a protective intestinal immunity, was used to determine the optimal inductive sites of the F4-specific intestinal immune response. Hereto, pigs were immunised with F4 orally, in the lumen of the mid-jejunum, ileum or mid-colon. Throughout the small intestine, the highest number of ASC was found following jejunal immunisation, followed by ileal, oral and colonic immunisation. To determine the signifance of Peyer's patches in the induced immune response, F4 was injected into the jejunal Peyer's patches (JPP), lamina propria (LP) and ileal Peyer's patches (IPP). Immunisation in the JPP induced the highest number ASC in the small intestine, whereas immunisation in the LP and IPP resulted in lower intestinal antibody responses. In conclusion, we have shown that the JPP are the major inductive sites of the F4-specific intestinal antibody response. This knowledge could be important when using the pig as an animal model for vaccination studies. |
| doi_str_mv | 10.1016/j.vaccine.2005.07.025 |
| format | Article |
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Escherichia coli are administered to induce a protective intestinal immunity, was used to determine the optimal inductive sites of the F4-specific intestinal immune response. Hereto, pigs were immunised with F4 orally, in the lumen of the mid-jejunum, ileum or mid-colon. Throughout the small intestine, the highest number of ASC was found following jejunal immunisation, followed by ileal, oral and colonic immunisation. To determine the signifance of Peyer's patches in the induced immune response, F4 was injected into the jejunal Peyer's patches (JPP), lamina propria (LP) and ileal Peyer's patches (IPP). Immunisation in the JPP induced the highest number ASC in the small intestine, whereas immunisation in the LP and IPP resulted in lower intestinal antibody responses. In conclusion, we have shown that the JPP are the major inductive sites of the F4-specific intestinal antibody response. This knowledge could be important when using the pig as an animal model for vaccination studies.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2005.07.025</identifier><identifier>PMID: 16099554</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animal models ; Animals ; Antibodies, Bacterial - biosynthesis ; Antibodies, Bacterial - blood ; Antibody-Producing Cells - immunology ; Antigens, Bacterial - administration & dosage ; Antigens, Bacterial - immunology ; Applied microbiology ; Biological and medical sciences ; Escherichia coli ; Escherichia coli - immunology ; Escherichia coli Proteins - administration & dosage ; Escherichia coli Proteins - immunology ; F4 (K88) fimbriae ; Fimbriae Proteins - administration & dosage ; Fimbriae Proteins - immunology ; Fundamental and applied biological sciences. Psychology ; Hogs ; Immune response ; Immune system ; Immunization ; Immunoglobulin A - biosynthesis ; Immunoglobulin A - blood ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - blood ; Immunoglobulin M - biosynthesis ; Immunoglobulin M - blood ; Immunological inductive site ; Intestinal immunisation ; Jejunum - immunology ; Microbiology ; Models, Animal ; Peyer's Patches - immunology ; Pig ; Rodents ; Small intestine ; Swine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2006-05, Vol.24 (18), p.3812-3820</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 1, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-d2c75fba997049850175c1daaaca79e20bc3ba4d4d1a64ac9c5d654db25cf53a3</citedby><cites>FETCH-LOGICAL-c452t-d2c75fba997049850175c1daaaca79e20bc3ba4d4d1a64ac9c5d654db25cf53a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1547145286?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17764037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16099554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Snoeck, V.</creatorcontrib><creatorcontrib>Verfaillie, T.</creatorcontrib><creatorcontrib>Verdonck, F.</creatorcontrib><creatorcontrib>Goddeeris, B.M.</creatorcontrib><creatorcontrib>Cox, E.</creatorcontrib><title>The jejunal Peyer's patches are the major inductive sites of the F4-specific immune response following intestinal immunisation of pigs with F4 (K88) fimbriae</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>A recently developed oral immunisation model in pigs in which F4 (K88) fimbriae of enterotoxigenic
Escherichia coli are administered to induce a protective intestinal immunity, was used to determine the optimal inductive sites of the F4-specific intestinal immune response. Hereto, pigs were immunised with F4 orally, in the lumen of the mid-jejunum, ileum or mid-colon. Throughout the small intestine, the highest number of ASC was found following jejunal immunisation, followed by ileal, oral and colonic immunisation. To determine the signifance of Peyer's patches in the induced immune response, F4 was injected into the jejunal Peyer's patches (JPP), lamina propria (LP) and ileal Peyer's patches (IPP). Immunisation in the JPP induced the highest number ASC in the small intestine, whereas immunisation in the LP and IPP resulted in lower intestinal antibody responses. In conclusion, we have shown that the JPP are the major inductive sites of the F4-specific intestinal antibody response. This knowledge could be important when using the pig as an animal model for vaccination studies.</description><subject>Animal models</subject><subject>Animals</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibody-Producing Cells - immunology</subject><subject>Antigens, Bacterial - administration & dosage</subject><subject>Antigens, Bacterial - immunology</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Escherichia coli</subject><subject>Escherichia coli - immunology</subject><subject>Escherichia coli Proteins - administration & dosage</subject><subject>Escherichia coli Proteins - immunology</subject><subject>F4 (K88) fimbriae</subject><subject>Fimbriae Proteins - administration & dosage</subject><subject>Fimbriae Proteins - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hogs</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunoglobulin M - blood</subject><subject>Immunological inductive site</subject><subject>Intestinal immunisation</subject><subject>Jejunum - immunology</subject><subject>Microbiology</subject><subject>Models, Animal</subject><subject>Peyer's Patches - immunology</subject><subject>Pig</subject><subject>Rodents</subject><subject>Small intestine</subject><subject>Swine</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc1u1DAUhSMEokPhEUCWEH-LBDux42SFUEUBUQkWRWJn3Tg3nRslcWonU_VheFc8nZEqsenKi_Od42OfJHkpeCa4KD_22Q6spQmznHOVcZ3xXD1KNqLSRZorUT1ONjwvZSoF_3OSPAuh5xEsRP00ORElr2ul5Cb5e7lF1mO_TjCwX3iL_l1gMyx2i4GBR7ZEfYTeeUZTu9qFdsgCLVF13Z14LtMwo6WOLKNxXCdkHsPspoCsc8Pgbmi6iuZoWWh_yx1EARZy0z5kpqvAbmjZxij2_kdVfWAdjY0nwOfJkw6GgC-O52ny-_zL5dm39OLn1-9nny9SK1W-pG1uteoaqGvNZV0pLrSyogUAC7rGnDe2aEC2shVQSrC1VW2pZNvkynaqgOI0eXvInb27XmNRM1KwOAwwoVuDKXUtpajyB0FRy0JWXETw9X9g71Yfnx8ZJbWIvasyUupAWe9C8NiZ2dMI_tYIbvYzm94cZzb7mQ3XJs4cfa-O6WszYnvvOu4agTdHAIKFofMwWQr3nNal5IWO3KcDh_F3d4TeBEs4WWzJo11M6-iBKv8APWbJ-A</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Snoeck, V.</creator><creator>Verfaillie, T.</creator><creator>Verdonck, F.</creator><creator>Goddeeris, B.M.</creator><creator>Cox, E.</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>The jejunal Peyer's patches are the major inductive sites of the F4-specific immune response following intestinal immunisation of pigs with F4 (K88) fimbriae</title><author>Snoeck, V. ; Verfaillie, T. ; Verdonck, F. ; Goddeeris, B.M. ; Cox, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-d2c75fba997049850175c1daaaca79e20bc3ba4d4d1a64ac9c5d654db25cf53a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibody-Producing Cells - immunology</topic><topic>Antigens, Bacterial - administration & dosage</topic><topic>Antigens, Bacterial - immunology</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Escherichia coli</topic><topic>Escherichia coli - immunology</topic><topic>Escherichia coli Proteins - administration & dosage</topic><topic>Escherichia coli Proteins - immunology</topic><topic>F4 (K88) fimbriae</topic><topic>Fimbriae Proteins - administration & dosage</topic><topic>Fimbriae Proteins - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hogs</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunization</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunoglobulin M - blood</topic><topic>Immunological inductive site</topic><topic>Intestinal immunisation</topic><topic>Jejunum - immunology</topic><topic>Microbiology</topic><topic>Models, Animal</topic><topic>Peyer's Patches - immunology</topic><topic>Pig</topic><topic>Rodents</topic><topic>Small intestine</topic><topic>Swine</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Snoeck, V.</creatorcontrib><creatorcontrib>Verfaillie, T.</creatorcontrib><creatorcontrib>Verdonck, F.</creatorcontrib><creatorcontrib>Goddeeris, B.M.</creatorcontrib><creatorcontrib>Cox, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snoeck, V.</au><au>Verfaillie, T.</au><au>Verdonck, F.</au><au>Goddeeris, B.M.</au><au>Cox, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The jejunal Peyer's patches are the major inductive sites of the F4-specific immune response following intestinal immunisation of pigs with F4 (K88) fimbriae</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>24</volume><issue>18</issue><spage>3812</spage><epage>3820</epage><pages>3812-3820</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>A recently developed oral immunisation model in pigs in which F4 (K88) fimbriae of enterotoxigenic
Escherichia coli are administered to induce a protective intestinal immunity, was used to determine the optimal inductive sites of the F4-specific intestinal immune response. Hereto, pigs were immunised with F4 orally, in the lumen of the mid-jejunum, ileum or mid-colon. Throughout the small intestine, the highest number of ASC was found following jejunal immunisation, followed by ileal, oral and colonic immunisation. To determine the signifance of Peyer's patches in the induced immune response, F4 was injected into the jejunal Peyer's patches (JPP), lamina propria (LP) and ileal Peyer's patches (IPP). Immunisation in the JPP induced the highest number ASC in the small intestine, whereas immunisation in the LP and IPP resulted in lower intestinal antibody responses. In conclusion, we have shown that the JPP are the major inductive sites of the F4-specific intestinal antibody response. This knowledge could be important when using the pig as an animal model for vaccination studies.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16099554</pmid><doi>10.1016/j.vaccine.2005.07.025</doi><tpages>9</tpages></addata></record> |
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| ispartof | Vaccine, 2006-05, Vol.24 (18), p.3812-3820 |
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| subjects | Animal models Animals Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood Antibody-Producing Cells - immunology Antigens, Bacterial - administration & dosage Antigens, Bacterial - immunology Applied microbiology Biological and medical sciences Escherichia coli Escherichia coli - immunology Escherichia coli Proteins - administration & dosage Escherichia coli Proteins - immunology F4 (K88) fimbriae Fimbriae Proteins - administration & dosage Fimbriae Proteins - immunology Fundamental and applied biological sciences. Psychology Hogs Immune response Immune system Immunization Immunoglobulin A - biosynthesis Immunoglobulin A - blood Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin M - biosynthesis Immunoglobulin M - blood Immunological inductive site Intestinal immunisation Jejunum - immunology Microbiology Models, Animal Peyer's Patches - immunology Pig Rodents Small intestine Swine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | The jejunal Peyer's patches are the major inductive sites of the F4-specific immune response following intestinal immunisation of pigs with F4 (K88) fimbriae |
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