Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus
This study was designed to investigate inducible intrinsic resistance against lactoferricin B in Staphylococcus aureus. Serial passage of seven S. aureus strains in medium with increasing concentrations of peptide resulted in an induced resistance at various levels in all strains. The induced resist...
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| Veröffentlicht in: | FEBS letters 2005-06, Vol.579 (16), p.3421-3426 |
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| creator | Samuelsen, Ørjan Haukland, Hanne H. Jenssen, Håvard Krämer, Manuela Sandvik, Kjersti Ulvatne, Hilde Vorland, Lars H. |
| description | This study was designed to investigate inducible intrinsic resistance against lactoferricin B in
Staphylococcus aureus. Serial passage of seven
S. aureus strains in medium with increasing concentrations of peptide resulted in an induced resistance at various levels in all strains. The induced resistance was unstable and decreased relatively rapidly during passages in peptide free medium but the minimum inhibitory concentration remained elevated after thirty passages. Cross-resistance to penicillin G and low-level cross-resistance to the antimicrobial peptides indolicidin and Ala
3,13,18-magainin was observed. No cross-resistance was observed to the human cathelicidin LL-37. In conclusion, this study shows that
S. aureus has intrinsic resistance mechanisms against antimicrobial peptides that can be induced upon exposure, and that this may confer low-level cross-resistance to other antimicrobial peptides. |
| doi_str_mv | 10.1016/j.febslet.2005.05.017 |
| format | Article |
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Staphylococcus aureus. Serial passage of seven
S. aureus strains in medium with increasing concentrations of peptide resulted in an induced resistance at various levels in all strains. The induced resistance was unstable and decreased relatively rapidly during passages in peptide free medium but the minimum inhibitory concentration remained elevated after thirty passages. Cross-resistance to penicillin G and low-level cross-resistance to the antimicrobial peptides indolicidin and Ala
3,13,18-magainin was observed. No cross-resistance was observed to the human cathelicidin LL-37. In conclusion, this study shows that
S. aureus has intrinsic resistance mechanisms against antimicrobial peptides that can be induced upon exposure, and that this may confer low-level cross-resistance to other antimicrobial peptides.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2005.05.017</identifier><identifier>PMID: 15946666</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antimicrobial Cationic Peptides - pharmacology ; Antimicrobial peptide ; Drug Resistance, Microbial ; Lactoferricin ; Lactoferrin - pharmacology ; Microbial Sensitivity Tests ; Penicillin G - pharmacology ; Resistance ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - physiology ; Staphylococcus aureus - ultrastructure</subject><ispartof>FEBS letters, 2005-06, Vol.579 (16), p.3421-3426</ispartof><rights>2005</rights><rights>FEBS Letters 579 (2005) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4590-b0134881dd08683da9f0ae1260c1891d75fb7caa7be69dfbc9e5d39b326b6ebf3</citedby><cites>FETCH-LOGICAL-c4590-b0134881dd08683da9f0ae1260c1891d75fb7caa7be69dfbc9e5d39b326b6ebf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2005.05.017$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579305006150$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3537,27903,27904,45553,45554,46387,46811,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15946666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samuelsen, Ørjan</creatorcontrib><creatorcontrib>Haukland, Hanne H.</creatorcontrib><creatorcontrib>Jenssen, Håvard</creatorcontrib><creatorcontrib>Krämer, Manuela</creatorcontrib><creatorcontrib>Sandvik, Kjersti</creatorcontrib><creatorcontrib>Ulvatne, Hilde</creatorcontrib><creatorcontrib>Vorland, Lars H.</creatorcontrib><title>Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>This study was designed to investigate inducible intrinsic resistance against lactoferricin B in
Staphylococcus aureus. Serial passage of seven
S. aureus strains in medium with increasing concentrations of peptide resulted in an induced resistance at various levels in all strains. The induced resistance was unstable and decreased relatively rapidly during passages in peptide free medium but the minimum inhibitory concentration remained elevated after thirty passages. Cross-resistance to penicillin G and low-level cross-resistance to the antimicrobial peptides indolicidin and Ala
3,13,18-magainin was observed. No cross-resistance was observed to the human cathelicidin LL-37. In conclusion, this study shows that
S. aureus has intrinsic resistance mechanisms against antimicrobial peptides that can be induced upon exposure, and that this may confer low-level cross-resistance to other antimicrobial peptides.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial Cationic Peptides - pharmacology</subject><subject>Antimicrobial peptide</subject><subject>Drug Resistance, Microbial</subject><subject>Lactoferricin</subject><subject>Lactoferrin - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Penicillin G - pharmacology</subject><subject>Resistance</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - physiology</subject><subject>Staphylococcus aureus - ultrastructure</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtr3DAUhUVpSaZpfkKLV915emVZsrQqTcgLAl2khe6EHtdEg8d2Jbll_n1kZqDLVFwkBN89VzqHkI8UthSo-LLb9mjTgHnbAPDtWrR7QzZUdqxmrZBvyQaAtjXvFDsn71PaQblLqs7IOeWqFWVtyK-H0S8OfRUxhZTN6LDKU5WfsTJjDvvg4mSDGaoZ5xw8VoNxeeoxxuDCWF1VZXvKZn4-DJObnFtSZZaIS_pA3vVmSHh5Oi_Iz9ubH9f39eP3u4frb4-1a7mC2gJlrZTUe5BCMm9UDwZpI8BRqajveG87Z0xnUSjfW6eQe6Ysa4QVaHt2QT4fdec4_V4wZb0PyeEwmBGnJWnRqZZJYK-CVPFGStkWkB_B8vWUIvZ6jmFv4kFT0Kv3eqdP3uvVe70W7Urfp9OAxe7R_-s6mV2A-yPwNwx4-D9VfXtz1TytQa45AgcQlEOR-nqUwmLtn4BRJxewhOdDRJe1n8Irr30BsZeu7g</recordid><startdate>20050620</startdate><enddate>20050620</enddate><creator>Samuelsen, Ørjan</creator><creator>Haukland, Hanne H.</creator><creator>Jenssen, Håvard</creator><creator>Krämer, Manuela</creator><creator>Sandvik, Kjersti</creator><creator>Ulvatne, Hilde</creator><creator>Vorland, Lars H.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050620</creationdate><title>Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus</title><author>Samuelsen, Ørjan ; Haukland, Hanne H. ; Jenssen, Håvard ; Krämer, Manuela ; Sandvik, Kjersti ; Ulvatne, Hilde ; Vorland, Lars H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4590-b0134881dd08683da9f0ae1260c1891d75fb7caa7be69dfbc9e5d39b326b6ebf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antimicrobial Cationic Peptides - pharmacology</topic><topic>Antimicrobial peptide</topic><topic>Drug Resistance, Microbial</topic><topic>Lactoferricin</topic><topic>Lactoferrin - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Penicillin G - pharmacology</topic><topic>Resistance</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - physiology</topic><topic>Staphylococcus aureus - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samuelsen, Ørjan</creatorcontrib><creatorcontrib>Haukland, Hanne H.</creatorcontrib><creatorcontrib>Jenssen, Håvard</creatorcontrib><creatorcontrib>Krämer, Manuela</creatorcontrib><creatorcontrib>Sandvik, Kjersti</creatorcontrib><creatorcontrib>Ulvatne, Hilde</creatorcontrib><creatorcontrib>Vorland, Lars H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samuelsen, Ørjan</au><au>Haukland, Hanne H.</au><au>Jenssen, Håvard</au><au>Krämer, Manuela</au><au>Sandvik, Kjersti</au><au>Ulvatne, Hilde</au><au>Vorland, Lars H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2005-06-20</date><risdate>2005</risdate><volume>579</volume><issue>16</issue><spage>3421</spage><epage>3426</epage><pages>3421-3426</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>This study was designed to investigate inducible intrinsic resistance against lactoferricin B in
Staphylococcus aureus. Serial passage of seven
S. aureus strains in medium with increasing concentrations of peptide resulted in an induced resistance at various levels in all strains. The induced resistance was unstable and decreased relatively rapidly during passages in peptide free medium but the minimum inhibitory concentration remained elevated after thirty passages. Cross-resistance to penicillin G and low-level cross-resistance to the antimicrobial peptides indolicidin and Ala
3,13,18-magainin was observed. No cross-resistance was observed to the human cathelicidin LL-37. In conclusion, this study shows that
S. aureus has intrinsic resistance mechanisms against antimicrobial peptides that can be induced upon exposure, and that this may confer low-level cross-resistance to other antimicrobial peptides.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>15946666</pmid><doi>10.1016/j.febslet.2005.05.017</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptide Drug Resistance, Microbial Lactoferricin Lactoferrin - pharmacology Microbial Sensitivity Tests Penicillin G - pharmacology Resistance Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Staphylococcus aureus - ultrastructure |
| title | Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus |
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