Mechanical compressive loading stimulates the activity of proximal region of human COL2A1 gene promoter in transfected chondrocytes

Previous studies have demonstrated that the mechanical compressive loading affects the biosynthesis of chondrocytes seeded in three dimensional scaffolds. In this study, the level of type II collagen mRNA expression was increased by a continuous dynamic compression at 10% compressive strain and 0.1...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-06, Vol.344 (4), p.1192-1199
Hauptverfasser:	Xie, J., Han, Z.Y., Matsuda, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chondrocytes Chondrocytes - metabolism COL2A1 Collagen Type II - genetics Compressive Strength Humans Mechanical compression Mechanotransduction, Cellular - genetics Poly( l-lactide-co-ε-caprolactone) (PLCL) Promoter Regions, Genetic - genetics Rabbits RNA Stability RNA, Messenger - metabolism Sequence Deletion Sp1 Sp1 Transcription Factor - metabolism Stress, Mechanical Transcriptional Activation
Online-Zugang:	Volltext
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