Rosiglitazone Controls Fatty Acid Cycling in Human Adipose Tissue by Means of Glyceroneogenesis and Glycerol Phosphorylation

Control of fatty acid homeostasis is crucial to prevent insulin resistance. During fasting, the plasma fatty acid level depends on triglyceride lipolysis and fatty acid re-esterification within fat cells. In rodents, Rosiglitazone® controls fatty acid homeostasis by stimulating two pathways in the a...

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Veröffentlicht in:	The Journal of biological chemistry 2006-05, Vol.281 (19), p.13141-13149
Hauptverfasser:	Leroyer, Stéphanie N., Tordjman, Joan, Chauvet, Geneviève, Quette, Joëlle, Chapron, Charles, Forest, Claude, Antoine, Bénédicte
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - metabolism Adult Body Weight Fatty Acids - pharmacology Female Glycerol - metabolism Glycerol Kinase - metabolism Humans Hypoglycemic Agents - pharmacology Phosphorylation - drug effects Pyruvates - metabolism Rosiglitazone Thiazolidinediones - pharmacology
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